蒙药三味皂矾汤的抗炎作用研究

目的：观察三味皂矾汤的抗炎作用,为该药的开发研究提供实验基础。方法：选择大鼠棉球肉芽肿、鸡蛋清致大鼠足肿胀和甲醛致大鼠足肿胀等实验模型观察三味皂矾汤的抗炎效果。结果：三味皂矾汤对大鼠棉球肉芽组织的增生有显著的抑制作用,其抑制率最高达到31.82%（P<0.01）,对1~6 h内蛋清致大鼠足肿胀的抑制率最高达到31.61%（P<0.01）,对1~24 h内甲醛致大鼠足肿胀的抑制率最高达到20.09%（P<0.01）。结论：三味皂矾汤对亚急性吞噬细胞的浸润性炎症和对慢性增殖性组织变异性炎症均有良好的抑制作用。     

Natural course of the impairment of endothelium-dependent relaxations after balloon endothelium removal in porcine coronary arteries. Possible dysfunction of a pertussis toxin-sensitive G protein

The purposes of the present study were to examine the natural course of the impairment of endothelium-dependent relaxations during a regeneration and tissue repair process after balloon endothelium removal and to elucidate the cellular mechanism(s) underlying it. Twenty-three male Yorkshire pigs underwent balloon endothelium removal along the proximal portion of either the left anterior descending or circumflex coronary artery and were then maintained on a regular chow for 4, 8, 16, or 24 weeks. Endothelium-dependent responses were examined in vitro in rings taken from the control and previously denuded arteries studied in parallel. Morphometric analysis revealed that intimal thickening developed only at the previously denuded area. In the previously denuded arteries with regenerated endothelium, the endothelium-dependent relaxations to UK 14304 (a selective alpha 2-adrenergic agonist), serotonin, and aggregating platelets were impaired 4 weeks after endothelium removal and remained so throughout the study. The endothelium-dependent relaxations to thrombin and adenosine diphosphate became depressed 8 weeks after endothelium removal and those to bradykinin became depressed 16 weeks after endothelium removal, while those to the calcium ionophore A23187 were maintained throughout the study. Endothelium-dependent relaxations to all vasoactive agents were unaltered in the control arteries. In the control arteries, pertussis toxin, an inhibitor of certain G proteins, markedly inhibited the endothelium-dependent relaxations to UK 14304 and serotonin and partially inhibited those to thrombin and aggregating platelets. The responses inhibited by the toxin in control arteries were significantly reduced in the reduced in the previously denuded arteries with regenerated endothelium. The inhibitory effect of pertussis toxin was markedly reduced in those arteries with regenerated endothelium. In quiescent rings, the presence of normal endothelium inhibited the contractions caused by serotonin and aggregating platelets; this endothelium-dependent depression was markedly impaired in the previously denuded arteries throughout the study. Direct relaxation of the coronary smooth muscle to nitric oxide or sodium nitroprusside or direct contraction to KCl or serotonin were comparable between the control and previously denuded arteries. These experiments indicate that endothelium-dependent relaxations progressively worsen after regeneration of the endothelium and that the dysfunction of a pertussis toxin-sensitive G protein partly account for the endothelial dysfunction in the chronic regenerated state.     

高血压患者心脏变时性功能不良及其意义

目的:探讨原发性高血压(EH)患者心脏变时性功能不良(CI)及其意义。方法:随机选择EH患者60例,行活动平板运动试验,记录心率、血压变化,运动时间(time)、代谢当量(METs);计算2级运动的心率变时性反应指数(CRI2)、最大心率收缩压二项乘积(RPP)和心肌耗氧量(MV.O2)并与正常对照组40例比较。结果:EH组峰值心率及心率上升幅度小于对照组(148.75±11.81):(154.27±12.05)次/min,(67.44±13.37):(74.12±14.43)次/min,P<0.05;CRI2低于对照组(0.94±0.22):(1.03±0.15),P<0.05;EH组CI的人数共29例(48.33%)明显多于对照组7例(17.5%),P<0.005,其中CRI2<0.8的人数20例(33.33%),CRI2>1.3的人数9例(15%),对照组为6例(15%)、1例(2.5%),两组间有显著性差异P<0.05;表明EH组存在CI;EH组运动时间(time)缩短(8.78±1.87):(9.77±1.88)min,P<0.05;运动贮量(METs)降低(9.21±1.39):(9.82±1.48),P<0.05;而RPP,MV.O2分别高于对照组[(26484.64±3573.49):(24118.39±3060.76),(30.78±5.0):(27.47±4.23)ml/kg.min,P<0.001]。结论:EH患者存在CI,提示有心脏自主神经损害,临床应引起重视。     

Sebaceous carcinoma of the lip: Comparing normal lip and cheek anatomy with the imaging features of a rare cutaneous malignancy

Sebaceous carcinoma is a rare cutaneous malignancy, commonly affecting the eyelids. This case highlights a patient who presented with sebaceous carcinoma of the right upper lip with extensive involvement of the soft tissues of the head and neck. As part of the initial investigation, ultrasound was requested. This case demonstrates the ultrasound features of sebaceous carcinoma as well as revising the normal ultrasound anatomy of the upper lip and muscles of the cheek.     

室壁应力与应变的关系评价高血压病左室收缩功能

目的　探索用室壁应力 (stress)与应变 (strain)的关系评价高血压病左室收缩功能的临床价值。方法　研究对象为 5 5例高血压病患者和 3 0例健康人。应用超声心动图计算左室射血分数 (EF)、心指数 (CI)、重量指数 (LVMI)和相对室壁厚度 (RWT) ,并联合袖带肱动脉血压值计算左心室收缩期室壁经线峰值应力 (Pσm)。根据LVMI和RWT将高血压病分为左室正常构型和左室重构两组。在数字化超声工作站中应用定量组织速度成像 (QTVI)获取左室前壁心肌 2个节段长轴应变曲线和峰值收缩应变值 (PSS)。结果　①以EF ,CI表示的心脏收缩功能 ,在高血压病左室正常构型组值中无明显变化 ;而在高血压病左室重构组中下降 ,差异具有极显著意义 (P <0 .0 1)。②Pσm在高血压病两组中较对照组均有增高 (P <0 .0 5～ 0 .0 1) ,两组间比较差异具有极显著意义 (P <0 .0 1)。③高血压病两组左室前壁基底段 (Bas)和中段 (Mid)的 pSS值均显著下降 (P <0 .0 1) ,两组间比较差异具有极显著意义 (P <0 .0 1)。④直线相关分析结果显示高血压病两组Pσm与PSSBas和PSSMid均呈显著负相关。根据正常构型组Pσm与PSSBas直线回归方程计算 ,在相同Pσm水平 ,左室重构组PSSBas的实测值显著低于预测值及实测值与预测值的比值较正常构型组显著下降 ,差     

Surgical ventricular reconstruction and subendocardial resection for the treatment of refractory ventricular tachycardia

We describe a case of 64-year-old female patient with ventricular tachycardia intractable to medical treatment and acute heart failure following myocardial infarction. Emergency surgical ventricular reconstruction and subendocardial resection was undertaken. We discuss the option of surgical intervention in this difficult and unusual clinical scenario.     

提高医学院校文科生生物化学教学质量策略探讨

生物化学是医学院校学生一门重要的公共基础课。大多数学生认为生物化学这门课程内容庞杂、名词术语繁多、抽象难懂、学习难度大,尤其对于生物学科与化学学科基础薄弱的文科生来讲,学习过程吃力,学习效果不理想,期末挂科率较高。本研究从文科生学习生物化学遇到的困难及教师面临的教学现状出发,找出问题,探讨具体应对策略,旨在提高学生学习生物化学课的兴趣和效果。