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91.
Gunther Antonissen Mathias Devreese Filip Van Immerseel Siegrid De Baere Sabine Hessenberger An Martel Siska Croubels 《Toxins》2015,7(2):560-571
Both deoxynivalenol (DON) and fumonisin B1 (FB1) are common contaminants of feed. Fumonisins (FBs) in general have a very limited oral bioavailability in healthy animals. Previous studies have demonstrated that chronic exposure to DON impairs the intestinal barrier function and integrity, by affecting the intestinal surface area and function of the tight junctions. This might influence the oral bioavailability of FB1, and possibly lead to altered toxicity of this mycotoxin. A toxicokinetic study was performed with two groups of 6 broiler chickens, which were all administered an oral bolus of 2.5 mg FBs/kg BW after three-week exposure to either uncontaminated feed (group 1) or feed contaminated with 3.12 mg DON/kg feed (group 2). No significant differences in toxicokinetic parameters of FB1 could be demonstrated between the groups. Also, no increased or decreased body exposure to FB1 was observed, since the relative oral bioavailability of FB1 after chronic DON exposure was 92.2%. 相似文献
92.
Vojtech Kucera Marcello Cabibbo Filip Prusa Jaroslav Fojt Jaroslav Petr-Soini Tomas Pilvousek Marie Kolarikova Dalibor Vojtech 《Materials》2021,14(5)
The chemical and phase composition of the coating and the coating/substrate interface of an Al-Si-coated 22MnB5 hot stamped steel was investigated by means of SEM-EDS, XRD, micro-XRD and electron diffraction. Moreover, the surface profile was analyzed by XPS and roughness measurements. The XPS measurements showed that the thickness of the Si and Al oxide layers increased from 14 to 76 nm after die-quenching, and that the surface roughness increased as well as a result of volume changes caused by phase transformations. In addition to the FeAl(Si) and Fe2Al5 phases and the interdiffusion layer forming complex structures in the coating, electron diffraction confirmed the presence of an Fe2Al5 phase, and also revealed very thin layers of Fe3(Al,Si)C, Fe2(Al,Si)5 and Al-bearing rod-shaped particles in the immediate vicinity of the steel interface. Moreover, the scattered nonuniform layer of the Fe2Al8Si phase was identified in the outermost layer of the coating. Despite numerous studies devoted to researching the phase composition of the Al-Si coating applied to hot stamped steel, electron diffraction revealed very thin layers and particles on the coating/substrate interface and outermost layer, which have not been analyzed in detail. 相似文献
93.
Martina Zlesk Milena Pavlíkov Adam Pivk imon Maruiak Ondej Jankovský Anna-Marie Lauermannov Michal Lojka Filip Anton
ík Zbyek Pavlík 《Materials》2021,14(6)
The ongoing tendency to create environmentally friendly building materials is nowadays connected with the use of reactive magnesia-based composites. The aim of the presented research was to develop an ecologically sustainable composite material based on MOC (magnesium oxychloride cement) with excellent mechanical, chemical, and physical properties. The effect of the preparation procedure of MOC pastes doped with graphene nanoplatelets on their fresh and hardened properties was researched. One-step and two-step homogenization techniques were proposed as prospective tools for the production of MOC-based composites of advanced parameters. The conducted experiments and analyses covered X-ray fluorescence, scanning electron microscopy, energy-dispersive spectroscopy, high-resolution transmission electron microscopy, sorption analysis, X-ray diffraction, and optical microscopy. The viscosity of the fresh mixtures was monitored using a rotational viscometer. For the hardened composites, macro- and micro-structural parameters were measured together with the mechanical parameters. These tests were performed after 7 days and 14 days. The use of a carbon-based nanoadditive led to a significant drop in porosity, thus densifying the MOC matrix. Accordingly, the mechanical resistance was greatly improved by graphene nanoplatelets. The two-step homogenization procedure positively affected all researched functional parameters of the developed composites (e.g., the compressive strength increase of approximately 54% after 7 days, and 37% after 14 days, respectively) and can be recommended for the preparation of advanced functional materials reinforced with graphene. 相似文献
94.
95.
Peter Bossuyt Erwin Dreesen Jordi Rimola Sofie Devuysere Yves De Bruecker Ragna Vanslembrouck Valérie Laurent Magaly Zappa Céline Savoye-Collet Benjamin Pariente Jérôme Filippi Filip Baert Geert D’Haens David Laharie Laurent Peyrin-Biroulet Séverine Vermeire 《Clinical gastroenterology and hepatology》2021,19(5):947-954.e2
96.
BCR‐ABL1 kinase domain mutational analysis of CD34+ stem/progenitor cells in newly diagnosed CML patients by next‐generation sequencing
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97.
Filip Zemrak Mark A. Ahlman Gabriella Captur Saidi A. Mohiddin Nadine Kawel-Boehm Martin R. Prince James C. Moon William G. Hundley João A.C. Lima David A. Bluemke Steffen E. Petersen 《Journal of the American College of Cardiology》2014
Background
Left ventricular (LV) trabeculation is highly variable among individuals and is increased in some diseases (e.g., congenital heart disease or cardiomyopathies), but its significance in population-representative individuals is unknown.Objectives
The goal of this study was to determine if excessive LV trabeculation in population-representative individuals is associated with preceding changes in cardiac volumes and function.Methods
For technical reasons, the extent of trabeculation, which is expressed as the ratio of noncompacted to compacted (NC/C) myocardium, was measured on cardiac magnetic resonance (CMR) long-axis cine images in 2,742 participants in the MESA (Multi-Ethnic Study of Atherosclerosis) (mean age 68.7 years; 52.3% women; 56.4% with hypertension; 16.8% with diabetes) at examination 5. These were considered in quintiles of trabeculation extent; the NC/C ratio of quintile 5 was 2.46 to 5.41. We determined the relationship between the maximal NC/C ratio and the preceding change (9.5 years between examinations 1 and 5) in end-systolic volume indexed (ESVi) to body surface area. Secondary analyses assessed the associations between the maximal NC/C ratio and preceding changes in end-diastolic volume indexed (EDVi) to body surface area and the ejection fraction (EF).Results
Over 9.5 years, the ESVi decreased by 1.3 ml/m2, the EDVi decreased by 5.1 ml/m2, and the EF decreased by 0.6% (p < 0.0001). Even in subjects with excessive trabeculation, there were no clinically relevant differences in LV volumes and systolic function changes among the quintiles of trabeculation extent.Conclusions
Greater extent of, and even excessive, LV trabeculation measured in end-diastole in asymptomatic population-representative individuals appeared benign and was not associated with deterioration in LV volumes or function during an almost 10-year period. 相似文献98.
Gesa H. Phler Filip Klimes Andreas Voskrebenzev Lea Behrendt Christoph Czerner Marcel Gutberlet Serghei Cebotari Fabio Ius Christine Fegbeutel Christian Schoenfeld Till F. Kaireit Erik F. Hauck Karen M. Olsson Marius M. Hoeper Frank Wacker Jens Vogel‐Claussen 《Journal of magnetic resonance imaging : JMRI》2020,52(2):610-619
99.