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排序方式: 共有5531条查询结果,搜索用时 15 毫秒
71.
Susanne Krämer James Lucas Francisca Gamboa Miguel Peñarrocha Diago David Peñarrocha Oltra Marcelo Guzmán-Letelier Sanchit Paul Gustavo Molina Lorena Sepúlveda Ignacio Araya Rubén Soto Carolina Arriagada Anne W Lucky Jemima E Mellerio Roger Cornwall Fatimah Alsayer Reinhard Schilke Mark Adam Antal Fernanda Castrillón Camila Paredes Maria Concepción Serrano Victoria Clark 《Special care in dentistry》2020,40(Z1):3-81
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Bordini Ester Alves Ferreira Cassiano Fernanda Balestrero Silva Isabela Sanches Pompeo Usberti Felipe Rochelle Anovazzi Giovana Pacheco Leandro Edgar Pansani Tasa Nogueira Leite Maria Lusa Hebling Josimeri de Souza Costa Carlos Alberto Soares Diana Gabriela 《Clinical oral investigations》2020,24(2):663-674
Clinical Oral Investigations - This study aimed to develop a porous chitosan–calcium–aluminate scaffold (CH-AlCa) in combination with a bioactive dosage of 1α,25-dihydroxyvitamin... 相似文献
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Eliane Roseli Winkelmann Fernanda Dallazen Angela Beerbaum Steinke Bronzatti Juliara Cristina Werner Lorenzoni Pollyana Windm?ller 《Brazilian Journal Of Cardiovascular Surgery》2015,30(1):40-48
Objective
To analyze a cardiac rehabilitation adapted protocol in physical therapy during the postoperative hospital phase of cardiac surgery in a service of high complexity, in aspects regarded to complications and mortality prevalence and hospitalization days.Methods
This is an observational cross-sectional, retrospective and analytical study performed by investigating 99 patients who underwent cardiac surgery for coronary artery bypass graft, heart valve replacement or a combination of both. Step program adapted for rehabilitation after cardiac surgery was analyzed under the command of the physiotherapy professional team.Results
In average, a patient stays for two days in the Intensive Care Unit and three to four days in the hospital room, totalizing six days of hospitalization. Fatalities occurred in a higher percentage during hospitalization (5.1%) and up to two years period (8.6%) when compared to 30 days after hospital discharge (1.1%). Among the postoperative complications, the hemodynamic (63.4%) and respiratory (42.6%) were the most prevalent. 36-42% of complications occurred between the immediate postoperative period and the second postoperative day. The hospital discharge started from the fifth postoperative day. We can observe that in each following day, the patients are evolving in achieving the Steps, where Step 3 was the most used during the rehabilitation phase I.Conclusion
This evolution program by steps can to guide the physical rehabilitation at the hospital in patients after cardiac surgery. 相似文献77.
Helen Reinhart Camargo Catarino Natália Pereira de Godoy Nayara Kastem Scharlack Lia Mara Grosso Neves Fernanda Oliveira de Gaspari de Gaspi Marcelo Augusto Marreto Esquisatto Maria Esméria Corezola do Amaral Fernanda Aparecida Sampaio Mendonça Gláucia Maria Tech dos Santos 《Lasers in medical science》2015,30(3):1069-1079
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Hitomi Hosoya Andrey S. Dobroff Wouter H. P. Driessen Vittorio Cristini Lina M. Brinker Fernanda I. Staquicini Marina Cardó-Vila Sara D’Angelo Fortunato Ferrara Bettina Proneth Yu-Shen Lin Darren R. Dunphy Prashant Dogra Marites P. Melancon R. Jason Stafford Kohei Miyazono Juri G. Gelovani Kazunori Kataoka C. Jeffrey Brinker Richard L. Sidman Wadih Arap Renata Pasqualini 《Proceedings of the National Academy of Sciences of the United States of America》2016,113(7):1877-1882
A major challenge of targeted molecular imaging and drug delivery in cancer is establishing a functional combination of ligand-directed cargo with a triggered release system. Here we develop a hydrogel-based nanotechnology platform that integrates tumor targeting, photon-to-heat conversion, and triggered drug delivery within a single nanostructure to enable multimodal imaging and controlled release of therapeutic cargo. In proof-of-concept experiments, we show a broad range of ligand peptide-based applications with phage particles, heat-sensitive liposomes, or mesoporous silica nanoparticles that self-assemble into a hydrogel for tumor-targeted drug delivery. Because nanoparticles pack densely within the nanocarrier, their surface plasmon resonance shifts to near-infrared, thereby enabling a laser-mediated photothermal mechanism of cargo release. We demonstrate both noninvasive imaging and targeted drug delivery in preclinical mouse models of breast and prostate cancer. Finally, we applied mathematical modeling to predict and confirm tumor targeting and drug delivery. These results are meaningful steps toward the design and initial translation of an enabling nanotechnology platform with potential for broad clinical applications.A long-term goal in contemporary cancer nanomedicine has been to design and generate drug delivery systems that improve the narrow therapeutic window associated with conventional chemotherapeutics (1, 2). Conceptually, several nanotechnology-based entity candidates, including protocells (3), biosynthetic nanoparticles (NPs), viruses, and liposome-based nanoparticles, could be targeted for active delivery through a defined cell surface ligand receptor system and/or physically triggered for finely tuned cargo release (2, 4, 5).Numerous efforts have been made to functionalize NPs by combining them with antibodies, aptamers, peptides, vitamins, or carbohydrates (6–8), but the majority of studies involve untargeted nanoplatforms (4, 9). In practice, targeting NPs is far from trivial, and ongoing challenges include synthesis and purification, selection of an appropriate ligand receptor, and specific composition for NP conjugation. Even the conjugation reaction itself may alter the binding of the tumor-targeting moiety to its receptor through conformational changes, steric freedom restriction, or orientation distortion (10, 11). Unfortunately, the cost-to-benefit ratio of these modifications often elevate the complexity of the NP synthesis, complicating regulatory hurdles because of formulations that are heterogeneous or difficult to reproduce (10, 12, 13).To minimize such drawbacks, NPs can be functionalized via virus-based nanoplatforms as an alternative for targeted cargo delivery (14–16). In particular, filamentous bacteriophage (phage)—a prokaryotic virus—is an attractive candidate to develop a bionanomedicine for cancer therapeutics because phage particles are cost-effectively produced with biological uniformity, as well as being physically robust and stable under harsh conditions (17). Notably, phage-based nanoplatforms are biocompatible and nonpathogenic with eukaryotic organisms and are able to preserve the desired cell targeting and internalization (18). Moreover, phage particles are ideal for incorporating other NPs, which can be released after reaching the tumor site. An admixture of colloidal gold NP (AuNP) with phage particles spontaneously organizes into hydrogel network-like fractal structures (19, 20). These hydrogel networks offer convenient multifunctional integration within a single entity for tumor targeting, enhanced fluorescence and dark-field microscopy, near-infrared (NIR) photon-to-heat conversion, and surface-enhanced Raman scattering (SERS)-based detection (20, 21).In the present work, we developed a tumor targeting theranostic (meaning a combination of therapeutics and diagnostics) hydrogel-based nanoplatform that enables ligand-directed tumor targeting, multimodal imaging capability, and triggered therapeutic cargo release. Our data suggest that targeted hydrogel photothermal therapy represents a functional theranostic approach (fostering “see and treat, treat and see”) in the diagnosis and management of tumors. 相似文献
80.
Sara García‐Jiménez German Bernal Fernández Maria Fernanda Martínez Salazar Antonio Monroy Noyola Cairo Toledano Jaimes Angelica Meneses Acosta Leticia Gonzalez Maya Elizabeth Aveleyra Ojeda Maria A. Terrazas Meraz Boll Marie‐Catherine Miguel A. Sánchez‐Alemán 《Journal of clinical laboratory analysis》2015,29(1):5-9