自体颅骨片洗必泰甘油液保存及再植的实验研究

取下活体兔颅盖骨，置洗必泰甘油液中保存。１０天后，将保存的骨片钻孔，施自体再植术，并以异体再植和空白对照。经Ｘ线摄片及组织学观察，结果发现，不论自体，还是同种异体再植，都呈现出良好的骨再生能力。提示，此种保存液具有保留骨诱导活性，消除骨的抗原性的作用。     

SURGICAL TREATMENT OF INTRACRANICAL ANEURYSMS (A REPORT OF 55 CASES)

<正> Fifty-five patients with intracranial cerebral aneurysmswere directly operated on. Surgical management of this disease, characteristics of intracranial aneurysms, and technical key points in treatment of aneurysms are discussed.     

左半结肠癌并梗阻一期手术切除吻合33例治疗体会

目的探讨左半结肠急性梗阻一期切除吻合的外科诊治方法。方法回顾性分析2004年1月-2012年6．14一期手术切除吻合左半结肠癌并梗阻患者33例的临床资料。结果33例均一期切除吻合,全组无术中死亡病例。术后出现并发症切口感染1例,肺部感染1例,无吻合口瘘及其他严重并发症发生。结论左半结肠急性梗阻患者在掌握好手术适应证和做好预防措施的情况下,施行一期切除吻合是安全可行的。     

Direct and efficient cellular transformation of primary rat mesenchymal precursor cells by KSHV

Infections by viruses are associated with approximately 12% of human cancer. Kaposi's sarcoma-associated herpesvirus (KSHV) is causally linked to several malignancies commonly found in AIDS patients. The mechanism of KSHV-induced oncogenesis remains elusive, due in part to the lack of an adequate experimental system for cellular transformation of primary cells. Here, we report efficient infection and cellular transformation of primary rat embryonic metanephric mesenchymal precursor cells (MM cells) by KSHV. Cellular transformation occurred at as early as day 4 after infection and in nearly all infected cells. Transformed cells expressed hallmark vascular endothelial, lymphatic endothelial, and mesenchymal markers and efficiently induced tumors in nude mice. KSHV established latent infection in MM cells, and lytic induction resulted in low levels of detectable infectious virions despite robust expression of lytic genes. Most KSHV-induced tumor cells were in a latent state, although a few showed heterogeneous expression of lytic genes. This efficient system for KSHV cellular transformation of primary cells might facilitate the study of growth deregulation mechanisms resulting from KSHV infections.     

Prevalence of Autoimmune Liver Disease Related Autoantibodies in Chinese Patients with Primary Biliary Cirrhosis

Background  

The prevalence of autoimmune liver disease (AiLD)-related autoantibodies has not been defined in Chinese patients with primary biliary cirrhosis (PBC) and therefore needs to be characterized.     

Association between the BANK1 rs3733197 polymorphism and polymyositis/dermatomyositis in a Chinese Han population

Clinical Rheumatology - The aim of our study was to investigate the association between single nucleotide polymorphisms (SNPs) in the BANK1 gene and polymyositis/dermatomyositis (PM/DM) in a...     

Coronary involvement in patients with Behçet’s disease

Clinical Rheumatology - To investigate the clinical features and potential risk factors of coronary involvement in Behçet’s disease (BD). In this case-control study, we retrospectively...     

超声内镜下注射A型肉毒毒素治疗贲门失弛症的临床研究

对１０例经上消化道钡餐、内镜和食管动力检测确诊为贲门失弛症的病人,在超声内镜辅助下于食管下段扩约肌（ＬＥＳ）分４点注射Ａ型肉毒毒素８０Ｕ（每点２０Ｕ）,对治疗前后主要症状打分,测定治疗前后食管下段扩约肌压力（ＬＥＳＰ）,进行统计学分析,以评价其疗效。治疗前病人主要症状打分为６．１０±２．０２;治疗后为１．３０±１．２７,差异有显著性意义（Ｐ＜０．０１）。ＬＥＳＰ治疗前为（５．０５±１．５６）ｋＰａ,治疗后为（３．３６±１．５１）ｋＰａ,差异有显著性意义（Ｐ＜０．０１）。无明显的不良反应和合并症发生。超声内镜下注射肉毒毒素治疗贲门失弛症为一简单、安全、有效的方法。     

Smoking Affects the Patterns of Metabolic Disorders and Metabolic Syndrome in Patients With First-Episode Drug-Naive Schizophrenia: A Large Sample Study Based on the Chinese Han Population

ObjectiveAlthough metabolic disorders and smoking are common in schizophrenia, few studies have investigated the effects of smoking on metabolic disorders or metabolic syndrome (MetS) in schizophrenia patients, especially in first-episode drug-naïve (FEDN) patients. We sought to investigate the differences in metabolic disorders and MetS between smoking and nonsmoking FEDN schizophrenia patients.MethodsA total of 428 FEDN schizophrenia patients and 435 controls were recruited. Blood pressure, waist circumference, body mass index (BMI), lipid profiles, and glucose metabolism were measured. The psychopathology was evaluated by Positive and Negative Syndrome Scale.ResultsFEDN schizophrenia patients had a higher smoking rate than controls (23.8% vs 14.0%, P < .001). After adjusting for confounding variables, the prevalence of MetS, overweight, hypertension, hypertriglyceridemia, elevated insulin, and insulin resistance in smoking patients was higher than those in nonsmoking patients, while overweight and hypertension were higher in the smoking controls than in nonsmoking controls (all P < .05). In smoking patients, triglyceridemia, high-density lipoprotein cholesterol, and fasting blood glucose were the main contributing components to MetS, while in nonsmoking patients, waist circumference, systolic blood pressure, triglyceridemia, high-density lipoprotein cholesterol, and fasting blood glucose were the main contributing components to MetS. In smoking patients, BMI and homeostatic model assessment for insulin resistance were associated factors of MetS (both P < .05). In nonsmoking patients, sex, BMI, insulin, and homeostatic model assessment for insulin resistance were associated factors of MetS (all P < .05).ConclusionsOur study indicates that smoking schizophrenia patients have a higher prevalence of MetS and metabolic disorders than nonsmoking patients. Moreover, smoking and nonsmoking patients have different contributing components and associated factors for MetS.