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101.
Henrique Faria Ramos Signe Schuster Grasel Roberto Miquelino de Oliveira Beck Edigar Resende de Almeida 《Acta oto-laryngologica》2015,135(3):246-253
Conclusion: The correlations between behavioral and auditory steady-state response (ASSR) thresholds were significant at 500, 1000, 2000, and 4000 Hz. ASSR presented high sensitivity and specificity in the detection of residual hearing in cochlear implant candidates when compared with warble-tone audiometry. Objectives: To assess residual hearing in cochlear implant candidates by comparing the electrophysiological thresholds obtained in dichotic single-frequency ASSR with behavioral thresholds at 500, 1000, 2000, and 4000 Hz. Methods: This was a comparative study between ASSR and warble-tone audiometry thresholds in 40 cochlear implant candidates (80 ears) before cochlear implantation with bilateral severe-to-profound sensorineural hearing loss. Results: Thresholds were obtained in 62.5% of all frequencies evaluated in warble-tone audiometry and in 63.1% in the ASSR. ASSR sensitivity was 96% and specificity was 91.6%. Mean differences between behavioral and ASSR thresholds did not reach significance at any frequencies. Strong correlations between behavioral and ASSR thresholds were observed in 500, 1000, and 2000 Hz and moderate in 4000 Hz, with correlation coefficients varying from 0.65 to 0.81. On 90% of occasions, ASSR thresholds were acquired within 10 dB of behavioral thresholds. 相似文献
102.
Gabriane Nascimento Porcino Luciana Maria Ribeiro Antinarelli Ana Carolina Ribeiro Gomes Maia Priscila Faria‐Pinto Alessandro Taunay‐Rodrigues Paulo Marcos Zech Coelho David Lee Nelson Marcus Luiz Oliveira Penido Elaine Soares Coimbra Eveline Gomes Vasconcelos 《The Journal of pharmacy and pharmacology》2019,71(12):1784-1791
103.
Vitor Costa Sim?es Bruno Santos Sara Magalh?es Gil Faria Donzília Sousa Silva José Davide 《International journal of surgery case reports》2014,5(8):547-550
INTRODUCTION
Duodenum is the second most frequent location for a diverticulum in the digestive tract. Complications are rare and perforation was only reported in less than 200 cases.PRESENTATION OF CASE
A 79-year-old female was admitted to Emergency Department with abdominal pain and vomiting for the last 24 h. A CT scan was performed and moderated extra-luminal air was identified. During surgery a fourth portion perforated duodenal diverticulum was diagnosed and duodenal resection was performed.DISCUSSION
First reported in 1710, the incidence of duodenal diverticula can be as high as 22%. Nevertheless complications are extremely rare and include haemorrhage, inflammation, compression of surrounding organs, neoplastic progression, cholestasis and perforation.As perforations are often retroperitoneal, symptoms are nonspecific and rarely include peritoneal irritation, making clinical diagnose a challenge.CT scan will usually present extra-luminal retroperitoneal air and mesenteric fat stranding, providing clues for the diagnosis.Although non-operative treatment has been reported in selected patients, standard treatment is surgery and alternatives are diverse including diverticulectomy or duodenopancreatectomy.CONCLUSION
Perforated diverticula of the fourth portion of the duodenum are extremely rare and current evidence still supports surgery as the primary treatment modality. 相似文献104.
105.
Thiago Thomaz Mafort MD PhD Agnaldo José Lopes MD PhD Cláudia Henrique da Costa MD PhD Mariana Soares da Cal MS Mariana Carneiro Lopes MD Bruno Rangel Antunes da Silva MD PhD Luana Fortes Faria MD Anamelia Costa Faria MD MSc Walter Costa MD Raquel Esteves Brandão Salles MD Marcos César Santos de Castro MD MSc Rogério Rufino MD PhD 《Journal of clinical ultrasound : JCU》2020,48(9):515-521
106.
Cytogenomic delineation and clinical follow‐up of two siblings with an 8.5 Mb 6q24.2‐q25.2 deletion inherited from a paternal insertion
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107.
Fabiano Pereira Cardoso Simone Angélica de Faria Amormino Walderez Ornelas Dutra Antônio Paulino Ribeiro Sobrinho Paula Rocha Moreira 《Journal of endodontics》2014
Introduction
Pattern recognition receptors, such as toll-like receptor 2 (TLR-2) and TLR-4, participate in the activation of immune cells by microorganisms in dental pulp. However, the expression levels of pattern recognition receptors can be modulated by epigenetic factors, especially DNA methylation. In this study, the methylation status of the TLR-2 and CD14 (TLR4 co-receptor) genes in healthy and inflamed human dental pulp was examined.Methods
The Methyl-Profiler DNA Methylation qPCR Assay was used to verify the DNA methylation patterns.Results
No differences in the methylation patterns were observed between the 2 groups. Most DNA was unmethylated in both groups.Conclusions
The hypomethylation of TLR2 and CD14 genes is a usual feature in human dental pulp. 相似文献108.
Maristela Soares Swerts Pereira Marcos A. Rossi Cristina Ribeiro Cardoso João Santana da Silva Léa Assed Bezerra da Silva Milton Carlos Kuga Gisele Faria 《Journal of endodontics》2014
Introduction
The aim of this study was to characterize the response of mouse subcutaneous tissue to triple antibiotic paste (TAP) using conventional light microscopy and real-time PCR (qRT-PCR).Methods
Polyethylene tubes containing TAP or calcium hydroxide (CH) (ie, the control group) were implanted in mouse subcutaneous tissue. Animals that received empty tubes or no tubes were used as additional controls. After periods of 7, 21, and 63 days postimplantation, the specimens were removed and subjected to histologic processing. The number of inflammatory cells and vessels, vessel areas, vascular density, and relative percentage of collagen were evaluated. Gene expression of proinflammatory (interleukin-1 beta, tumor necrosis factor alpha, and interleukin 17) and anti-inflammatory (transforming growth factor beta) cytokines and angiogenic factors (vascular endothelial growth factor and hypoxia-inducible factor-1 alpha) was quantified by 7 and 21 days postimplantation. Results were analyzed using the Student t test, analysis of variance, and the Tukey test (α = 0.05).Results
TAP induced an exuberant inflammatory and angiogenic response, with higher numbers of inflammatory cells, higher vascular area and density, and lower relative percentage of collagen compared with CH. In general, the expression of genes involved in inflammation and angiogenesis was higher in the TAP group compared with animals that received CH or empty tubes.Conclusions
The response of mouse subcutaneous tissue to TAP was characterized by exuberant and persistent inflammatory and angiogenic responses with no repair and high gene expression of biomarkers associated with inflammation and angiogenesis. 相似文献109.
Karina Morais Faria Thais Bianca Brandão Ana Carolina Prado Ribeiro Adriele Ferreira Gouvêa Vasconcellos Icaro Thiago de Carvalho Fernando Freire de Arruda Gilberto Castro Junior Vanessa Cristina Gross Oslei Paes Almeida Marcio Ajudarte Lopes Alan Roger Santos-Silva 《Journal of endodontics》2014
Introduction
Teeth are often included in the radiation field during head and neck radiotherapy, and recent clinical evidence suggests that dental pulp is negatively affected by the direct effects of radiation, leading to impaired sensitivity of the dental pulp. Therefore, this study aimed to investigate the direct effects of radiation on the microvasculature, innervation, and extracellular matrix of the dental pulp of patients who have undergone head and neck radiotherapy.Methods
Twenty-three samples of dental pulp from patients who finished head and neck radiotherapy were analyzed. Samples were histologically processed and stained with hematoxylin-eosin for morphologic evaluation of the microvasculature, innervation, and extracellular matrix. Subsequently, immunohistochemical analysis of proteins related to vascularization (CD34 and smooth muscle actin), innervation (S-100, NCAM/CD56, and neurofilament), and extracellular matrix (vimentin) of the dental pulp was performed.Results
The morphologic study identified preservation of the microvasculature, nerve bundles, and components of the extracellular matrix in all studied samples. The immunohistochemical analysis confirmed the morphologic findings and showed a normal pattern of expression for the studied proteins in all samples.Conclusions
Direct effects of radiotherapy are not able to generate morphologic changes in the microvasculature, innervation, and extracellular matrix components of the dental pulp in head and neck cancer patients. 相似文献110.
Thiana Santiago Nascimento Esther Faria Braga Giselle Cristina Casaes Gomes William Romo Batista Andr Luís Mazzei Albert Rosangela Sabbatini Capella Lopes Claudio Cerqueira Lopes 《RSC advances》2020,10(2):1050
A chemoselective route for the synthesis of 1-O-alkylglycerols chimyl (1), batyl (2), and selachyl (3) is reported. These compounds can be naturally isolated from shark liver oil and the skin of animals such as stingrays and chimeras and exhibit potential anti-fouling activity. The synthetic approach developed in this work included two distinct methods of preparation. The first was based on solvent-free reactions catalyzed by onium quaternary salts (N and P) and ionic liquids; the second methodology was based on a series of one-pot reactions.A chemoselective route for the synthesis of 1-O-alkylglycerols chimyl (1), batyl (2), and selachyl (3) is reported. 相似文献