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61.
62.
Botero JE Yepes FL Roldán N Castrillón CA Hincapie JP Ochoa SP Ospina CA Becerra MA Jaramillo A Gutierrez SJ Contreras A 《Journal of periodontology》2012,83(10):1245-1250
Background: Periodontal disease has been associated with diabetes, but there is still controversy on the relationship between periodontal clinical parameters and glycemic control. The purpose of this study is to assess the relationship between blood glucose levels and clinical parameters of periodontal disease in individuals with diabetes. Methods: A total of 65 individuals with diabetes and 81 individuals without diabetes were included in the study. A full-mouth periodontal examination and preprandial fasting glycemia values were recorded for each individual. Glycosylated hemoglobin was only measured in patients with diabetes. A comparative analysis between groups (Mann-Whitney U test) and a correlation analysis between glycemia and periodontal parameters were performed (Spearman test). Results: Patients without diabetes presented more teeth than individuals with diabetes (P <0.05). Patients with diabetes with periodontitis displayed loss of periodontal clinical attachment compared to patients without diabetes, but the highest value was observed in patients with periodontitis that reported a smoking habit. Furthermore, patients with diabetes with periodontitis presented higher glycemia and glycated hemoglobin values in contrast to patients with gingivitis. Patients with diabetes with hyperglycemia had a higher risk to develop periodontitis (odds ratio = 2.24; 95% confidence interval = 1.02 to 4.93). A positive correlation was observed between glycemia and clinical attachment loss (AL), whereas a negative correlation between glycemia and the number of teeth present was found (P <0.05). Conclusions: Tooth and periodontal AL were increased by hyperglycemia in individuals with diabetes. This study contributes additional evidence that diabetes could aggravate periodontal disease and affect the systemic health of individuals. 相似文献
63.
Ségolène Billot Dominique Hervé Hasan O. Akman Roseline Froissart Christiane Baussan Kristl G. Claeys Monique Piraud Frédéric Sedel Fanny Mochel Pascal Laforêt 《Journal of the neurological sciences》2013,324(1-2):179-182
Adult polyglucosan body disease (APBD) is a metabolic disorder usually caused by glycogen branching enzyme (GBE) deficiency. APBD associates progressive walking difficulties, bladder dysfunction and, in about 50% of the cases, cognitive decline. APBD is characterized by a recognizable leukodystrophy on brain MRI. We report here a novel presentation of this disease in a 35-year old woman who presented with an acute deterioration followed by an unexpected recovery. Enzymatic analysis displayed decreased GBE activity in leukocytes. Molecular analyses revealed that only one mutated allele was expressed, bearing a p.Arg515His mutation. This is the first observation reporting acute and reversible neurological symptoms in APBD. These findings emphasize the importance of searching GBE deficiency in patients presenting with a leukodystrophy and acute neurological symptoms mimicking a stroke, in the absence of cardiovascular risk factors. 相似文献
64.
Benoit Mesnard Maxime Leroy James Hunter Delphine Kervella Marc-Olivier Timsit Lionel Badet Pascal Glemain Emmanuel Morelon Fanny Buron Moglie Le Quintrec-Donnette Vincent Pernin Marc Ladriere Sophie Girerd Christophe Legendre Antoine Sicard Laeticia Albano Stephane De Vergie Clarisse Kerleau Thomas Prudhomme Jérôme Rigaud Diego Cantarovich Gilles Blancho Georges Karam Magali Giral Simon Ville Julien Branchereau For the Données Informatisées et VAlidées en Transplantation/Computerized VAlidated Data in Transplantation Consortium Affiliations† 《BJU international》2022,129(2):225-233
65.
Advagraf®, a once‐daily prolonged release tacrolimus formulation,in kidney transplantation: literature review and guidelines from a panel of experts
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Sophie Caillard Bruno Moulin Fanny Buron Christophe Mariat Vincent Audard Philippe Grimbert Pierre Marquet 《Transplant international》2016,29(8):860-869
The efficacy and safety of tacrolimus twice‐a‐day (BID) and once‐a‐day (QD) formulations are similar. However, the available information regarding the initiation and management of tacrolimus QD is sparse and practical information is lacking. A panel of French experts extensively reviewed the available literature on tacrolimus pharmacokinetics, clinical efficacy, and safety in kidney transplantation and, based on their own day‐to‐day experience, provided the practitioners with practical guidelines for the daily use and management of tacrolimus QD in de novo initiation or early conversion. 相似文献
66.
Ravi Krupa Killen Annabel Alexander Angus Bell-Davies Frances Biganiro Sebintu James Brazeal Aurelia Butoyi Jean Marie Vianney Diaz Fabio Edgardo Drabile Romeo Fanny Marvin Fernie Lucila Gunawardana Shannon Hartley Emma Hawu Yolisa N. Hendron Holly Joseph Stephanie Alcine Lamahewage Ananda Mahagedera Ruwantha Manirambona Emery Morisho Benjamin Kitambala Muchunu Patrick Niyukuri Alliance Ntaganda Edmond Orliacq Francisco Orliacq Josefina Wobenjo Adili Young Pablo Lakhoo Kokila Ford Kathryn 《World journal of surgery》2022,46(3):476-485
World Journal of Surgery - The Global Initiative for Children's Surgery (GICS) group produced the Optimal Resources for Children’s Surgery (OReCS) document in 2019, listing standards of... 相似文献
67.
Fanny Lebreton Kevin Bellofatto Charles H. Wassmer Lisa Perez Vanessa Lavallard Graldine Parnaud David Cottet‐Dumoulin Julie Kerr‐Conte Franois Pattou Domenico Bosco Vronique Othenin‐Girard Begoa Martinez de Tejada Ekaterine Berishvili 《American journal of transplantation》2020,20(6):1551-1561
Hypoxia is a major cause of considerable islet loss during the early posttransplant period. Here, we investigate whether shielding islets with human amniotic epithelial cells (hAECs), which possess anti‐inflammatory and regenerative properties, improves islet engraftment and survival. Shielded islets were generated on agarose microwells by mixing rat islets (RIs) or human islets (HI) and hAECs (100 hAECs/IEQ). Islet secretory function and viability were assessed after culture in hypoxia (1% O2) or normoxia (21% O2) in vitro. In vivo function was evaluated after transplant under the kidney capsule of diabetic immunodeficient mice. Graft morphology and vascularization were evaluated by immunohistochemistry. Both shielded RIs and HIs show higher viability and increased glucose‐stimulated insulin secretion after exposure to hypoxia in vitro compared with control islets. Transplant of shielded islets results in considerably earlier normoglycemia and vascularization, an enhanced glucose tolerance, and a higher β cell mass. Our results show that hAECs have a clear cytoprotective effect against hypoxic damages in vitro. This strategy improves β cell mass engraftment and islet revascularization, leading to an improved capacity of islets to reverse hyperglycemia, and could be rapidly applicable in the clinical situation seeing that the modification to HIs are minor. 相似文献
68.
69.
Pierre Joly Benjamin Misson Fanny Perrière Frédérique Bonnemoy Muriel Joly Florence Donnadieu-Bernard Jean-Pierre Aguer Jacques Bohatier Clarisse Mallet 《Ecotoxicology (London, England)》2014,23(9):1648-1658
Soil phototrophic microorganisms, contributors to soil health and food webs, share their particular metabolism with plants. Current agricultural practices employ mixtures of pesticides to ensure the crops yields and can potentially impair these non-target organisms. However despite this environmental reality, studies dealing the susceptibility of phototrophic microorganisms to pesticide mixtures are scarce. We designed a 3 months microcosm study to assess the ecotoxicity of realistic herbicide mixtures of formulated S-metolachlor (Dual Gold Safeneur®), mesotrione (Callisto®) and nicosulfuron (Milagro®) on phototrophic communities of two soils (Limagne vertisol and Versailles luvisol). The soils presented different colonizing communities, with diatoms and chlorophyceae dominating communities in Limagne soil and cyanobacteria and bryophyta communities in Versailles soil. The results highlighted the strong impairment of Dual Gold Safeneur® treated microcosms on the biomass and the composition of both soil phototrophic communities, with no resilience after a delay of 3 months. This study also excluded any significant mixture effect on these organisms for Callisto® and Milagro® herbicides. We strongly recommend carrying on extensive soil studies on S-metolachlor and its commercial formulations, in order to reconsider its use from an ecotoxicological point of view. 相似文献
70.
ObjectivesTo explore the patients’ experiences of participating in an exercise group following anterior cruciate ligament reconstruction (ACLR).DesignHermaneutic phenomenological qualitative study of two focus groups.SettingOutpatient care, private rehabilitation centre.ParticipantsNine adults who had participated in an exercise group led by a physiotherapist following ACLR.ResultsThree major themes emerged from the data: psychosocial factors, physical outcomes and identity of the exercise group. The most significant perception of engaging in an exercise group following ACLR was its influence on psychosocial factors, especially motivation, self-confidence and social support. The group influenced the participants’ motivation, enjoyment and commitment to exercise during their rehabilitation. Social support, self-confidence and reassurance were mostly gained. The participants taking part in sport experienced the ACLR group as a substitute for sport trainings. The group was perceived to help enhance speed of recovery and facilitate the return to normal life, especially for participants with lower reported motivation and adherence to home-exercises. The authors interpreted that the subjective physical outcomes’ improvements described by all the participants was potentially an increased level of self-efficacy.The challenging role of the physiotherapist was highlighted as well as the promotion of shared accountability between patients and the group’s leader. The exercise group’s identity was questioned within the rehabilitation process, and the need for more knowledge of its existence in order to promote exercise group therapy was suggested.ConclusionParticipating in an exercise group therapy influences psychosocial factors such as motivation, self-confidence, social support, potentially self-efficacy and helps enhance a faster successful recovery following ACLR. Our findings indicate that participants with a lower reported adherence to home-exercises may especially benefit from it. 相似文献