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OBJECTIVE: To study the value of serum progesterone in selecting the candidate patients with ectopic pregnancy (EP) for methotrexate (MTX) treatment and in monitoring the effect of the treatment. METHODS: Thirty-seven EP patients who were given single-dose intramuscular injection with 50 mg/m2 MTX were divided into success and failure groups according to the effect of the treatment. The serum progesterone concentrations in these patients were measured and compared between the 2 groups, and the receiver-operator curves (ROC) were used to determine the critical serum progesterone levels for assessing the effect of MTX treatment. The time consumed respectively by serum progesterone and beta-human chorionic gonadotrophin (beta-hCG) decreasing to below normal level was also compared. RESULTS: The serum progesterone concentrations of the success group (7.93+/-2.02 ng/ml) were significantly lower than those of the failure group (14.53+/-1.72 ng/ml, P<0.05). The recommended critical level for assessing the effect of MTX treatment for EP patients was 11 ng/ml according to the ROC, and the time for serum progesterone decreasing to below normal level was significantly less than that for beta-hCG. CONCLUSION: Serum progesterone can be used as an index for selecting candidate EP patients for MTX treatment, and also as a good indicator for assessing the therapeutic effect after treatment. 相似文献
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The Lipid-regulating Effects of Atorvastatin on Type 2 Elder Diabetes Patients with Hyperlipidemia 总被引:1,自引:0,他引:1
Inthisstudy,theeffectofatorvastatinonlipidmetabolism ,especiallysLDL ,intype 2elderdiabetespatientswithhyperlipidemiawasstudy .Theresultswerepresentedasfollows.1 SUBJECTSANDMETHODS1 1 SubjectsThesubjectsincluded 2 6patientswithtype 2elderdiabetesandhyp… 相似文献
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实验小鼠肠道正常菌群 总被引:2,自引:0,他引:2
范薇 《中国比较医学杂志》2004,14(1):58-60
在动物肠道中栖息的细菌,构成了肠道正常菌群。实验动物的质量与肠道菌群的状态有着十分密切的联系,肠道菌群平衡状态在维持动物机体的生理状态、正常功能,以及抵抗外袭菌方面起着重要的作用。小鼠肠道中,每克肠内容物含有上亿个菌体,可分为10~15个属,上百个种。肠道正常菌群的主要菌属有双歧杆菌、拟杆菌(类杆菌)、肠球菌、乳杆菌、梭杆菌、真杆菌。不同品系的小鼠之间,各种菌的数量有所不同。本文简要介绍了近年来对小鼠肠道正常菌群的研究进展。 相似文献
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Objective To study the protective effects of adenovirus-mediated human beta-nerve growth factor gene (hNGFβ) transfer combined with iron fortified nutrition on blast hearing damage in guinea pigs. Methods Deafness was induced by blast (172dB SPL) in 35 healthy guinea pigs. Seven days after noise exposure, 10 guinea pigs were inoculated with adenovirus-mediated hNGFβ (Ad-hNGFβ) into the perilymphatic space (the gene group), another 10 guinea pigs were given hNGFβ combined with iron fortified nutritional diet (the combination group), still another 10 guinea pigs were inoculated with artificial perilymphatic fluid (APF), and 5 guinea pigs served as control, given neither medicine nor noise exposure. Auditory brainstem response (ABR) threshold shifts were monitored in the guinea pigs before blast exposure and after gene transfer. Changes in cochlear morphology were examined with immunohistochemical and HE staining. Results One week after successful inoculation of hNGFβ, it was noted that Ad-hNGFβ protein was expressed in each turn of the cochlea, and its intensity was almost equal. After gene transfer in the combination group and the gene group, ABR threshold shifts at week 1 and 4 were significantly smaller than those of the APF group. HE staining showed that the number of the spiral ganglion cells in the combination group and the Ad-hNGFβ group was significantly higher than that of the control group after 4 weeks (P<0.01). Conclusions Ad-hNGFβ combined with iron fortified nutritional diet was effective in the prevention and treatment of blast hearing damage of cochlear hair cells. 相似文献
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精索扭转误诊24例分析 总被引:5,自引:0,他引:5
目的:分析精索扭转误诊的原因及教训,提高临床医生对该病的认识水平与警惕性,以减少误诊的发生。方法:对24例外院误诊的精索扭转病例进行回顾性分析。结果:24例患者均经手术证实为精索扭转,因未能及时诊断,延误时机而切除缺血坏死的睾丸。结论:彩色多普勒血流动态显像应作为诊断该疾病的常规与首选检查方法,对精索扭转一旦确诊或疑有精索扭转的患者应及早行紧急复位,以期挽救睾丸。同时行睾丸固定术也十分必要,对于确诊毫无保留价值的睾丸需行切除。 相似文献
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本文将聚乙二醇(PEG)比浊法和固相酶联免疫法(ELISA)结合,建立了—较灵敏的免疫复合物(IC)直接固相吸附抗原特异性检测法。利用牛清蛋白(BSA)为已知抗原组份的IC模型,分别对IC直接固相吸附的条件和影响因素、方法的灵敏度、重复性等进行了研究。结果发现IC在解离状态下直接固相吸附后的抗原特异性检测灵敏度明显高于未解离者。该法具有简单易行,灵敏度较高、适于临床测定大量血清样品等优点。 相似文献