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排序方式: 共有1949条查询结果,搜索用时 31 毫秒
61.
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63.
Nutrient Insufficiencies/Deficiencies in Children With Sickle Cell Disease and Its Association With Increased Disease Severity
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64.
Gurpreet Singh MD Doan Le MD FAAP FRCPC Kareena Schnabl MSc PhD FCACB Michael T. Leaker MD FRCPC MacGregor Steele MD FRCPC Rebecca L. Sparkes MD FRCPC FCCMG 《Pediatric blood & cancer》2016,63(4):740-742
The classic principles put forth by Wilson and Jungner are often applied to determine the suitability of a condition for universal newborn screening. The three cases described here portray the harmful effects of vitamin B12 deficiency in infancy. The challenges and opportunities of early recognition and treatment are highlighted. Screening newborns would allow early detection and prevention of severe neurological damage in vitamin B12‐deficient infants and enable diagnosis of unrecognized maternal pernicious anemia in asymptomatic mothers. However, lack of standardized methodology and screening cutoffs present challenges to the use of current tandem mass spectrometry technologies for screening. 相似文献
65.
Guideline for the Treatment of Breakthrough and the Prevention of Refractory Chemotherapy‐Induced Nausea and Vomiting in Children With Cancer
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Jacqueline Flank BScPhm ACPR MSc Paula D. Robinson MD MSc Mark Holdsworth PharmD Robert Phillips MD Carol Portwine MD FRCPC PhD Paul Gibson MD Cathy Maan PhD CPsych Nancy Stefin Hons BA CLSt Dipl CCLS Lillian Sung MD PhD L. Lee Dupuis MScPhm ACPR PhD 《Pediatric blood & cancer》2016,63(7):1144-1151
This clinical practice guideline provides an approach to the treatment of breakthrough chemotherapy‐induced nausea and vomiting (CINV) and the prevention of refractory CINV in children. It was developed by an international, interprofessional panel and is based on systematic literature reviews. Evidence‐based interventions for the treatment of breakthrough and prophylaxis of refractory CINV are recommended. Gaps in the evidence used to support the recommendations made in this clinical practice guideline were identified. The contribution of these recommendations to breakthrough and refractory CINV control in children requires prospective evaluation. 相似文献
66.
Mohamed Abdelhaleem MD PhD FRCP Gino R. Somers MBBS PhD FRCPA Chaim Roifman MD FRCP FCACB Stanley Read MD PhD FRCPC Oussama Abla MD 《Pediatric blood & cancer》2016,63(9):1674-1676
Primary effusion lymphoma (PEL) is a rare lymphoma that occurs more frequently in immunocompromised adults and has a poor survival. We report a 9‐year‐old female with combined immunodeficiency with an Epstein–Barr virus positive/human herpes virus 8 negative PEL‐like lymphoma. The treatment with systemic chemotherapy for non‐Hodgkin lymphoma, zidovudine, and interferon‐α failed to control disease progression. This is the first reported pediatric case of PEL‐like lymphoma. Increased diagnostic awareness and more effective treatment strategies are needed for this rare lymphoma. 相似文献
67.
68.
Is there an Upgrading to Malignancy at Surgery of Mucocele‐Like Lesions Diagnosed on Percutaneous Breast Biopsy?
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Josée Morin MD Christine Desbiens MD FRCSC Brigitte Poirier MD FRCSC Éric Poirier MD FRCSC Jean‐Charles Hogue PhD Simon Jacob MD Gary Côté MD FRCPC 《The breast journal》2016,22(2):173-179
Management of pure mucocele‐like lesion (MLL) diagnosed on percutaneous breast biopsy (PBB) is controversial. To assess surgical upgrade rate and clinical outcome of pure MLL obtained as sole diagnosis on PBB. Patients diagnosed with a MLL as the most advanced lesion on PBB from April 1997 to December 2010 were reviewed for radiologic presentation, biopsy technique, and pathologic and clinical outcomes. Of the 21,340 image‐guided PBB performed during the study period, 50 women with 51 MLL (0.24%) were identified. Mean age was 53.1 ± 7.7 years. Radiologic findings were mostly microcalcifications (n = 47, 92.2%). Stereotactic PBB was performed for 49 lesions (96.1%). Surgery was performed shortly after biopsy in 35 women, with benign final pathology in 33, and upgrade to ductal carcinoma in situ (DCIS) in two patients (2/35, 5.7%). Mean follow‐up was 4.2 ± 2.5 years (3.7 ± 2.1 years for surgical patients; 5.9 ± 2.9 years for follow‐up only patients); three women were lost to follow‐up (3/50). Three invasive cancers (3/47, 6.4%) were diagnosed 1.2, 1.2, and 2.8 years after biopsy: two in surgical patients, and one in a follow‐up only patient. No cancer occurred at the same site as the original MLL. Pure MLL lesion of the breast is a rare entity and is mostly associated with a benign outcome. We observed an upgrade to DCIS slightly superior to 5%, but no invasive cancer. It is therefore unclear if these lesions should be excised or clinically and radiologically followed up when such lesions are found at PBB. 相似文献
69.
ATM,THMS, and RRM1 protein expression in nasopharyngeal carcinomas treated with curative intent
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Jenny Jaeeun Ko MD FRCPC Alexander C. Klimowicz PhD Amanda Jagdis MD Tien Phan MD FRCPC Janessa Laskin MD FRCPC Harold Y. Lau MD FRCPC Jodi E. Siever MSc Stephanie K. Petrillo MSc Thomas A. Thomson MD FRCPC M. Sarah Rose PhD Gwyn Bebb MBMCh PhD FRCPC Anthony M. Magliocco MD FRCPC FCAP Desirée Hao MD FRCPC 《Head & neck》2016,38(Z1):E384-E391
70.
Impact of p16 expression,nodal status,and smoking on oncologic outcomes of patients with head and neck unknown primary squamous cell carcinoma
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