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排序方式: 共有217条查询结果,搜索用时 31 毫秒
51.
FC Connell K Gordon G Brice V Keeley S Jeffery PS Mortimer S Mansour P Ostergaard 《Clinical genetics》2013,84(4):303-314
Historically, primary lymphoedema was classified into just three categories depending on the age of onset of swelling; congenital, praecox and tarda. Developments in clinical phenotyping and identification of the genetic cause of some of these conditions have demonstrated that primary lymphoedema is highly heterogenous. In 2010, we introduced a new classification and diagnostic pathway as a clinical and research tool. This algorithm has been used to delineate specific primary lymphoedema phenotypes, facilitating the discovery of new causative genes. This article reviews the latest molecular findings and provides an updated version of the classification and diagnostic pathway based on this new knowledge. 相似文献
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Sally Feeney FC Surg Sharon Rees PhD FRSM Mark Tagoe FC Surg 《The Journal of foot and ankle surgery》2007,46(2):80-85
The clinical outcomes of 19 patients requiring autogenous grafts for foot surgery were followed up until healing at the donor site occurred. In all cases, tricortical bone was extracted from the calcaneus for use at another pedal site. The first cohort of 9 patients had the calcaneal deficit replaced with allogenic cubes. The second cohort received no tissue replacement. Patients were reviewed postoperatively with a questionnaire and clinical examination to evaluate the outcome of the operations. Radiographic outcomes were observed at the donor and recipient sites in both groups until healing was confirmed as bridging trabeculation. Incorporation of the graft at the donor site was also reviewed. Clinical outcomes, namely pain, local sensory function, and return to footwear, were satisfactory in all patients and were not significantly different between groups. One patient from each group sustained a heel fracture. The donated autogenous grafts at the recipient sites were all incorporated uneventfully at 6 months. In the first cohort, allogenic graft incorporation in the calcaneus was complete in only 2 patients at the 12-month stage. The remaining 7 cases showed reduction of the deficit by new bone formation arising from the calcaneus. Donor sites with allogenic bone replacement healed at a median of 18 months (interquartile range, 18-18 months). In the group without replacement, healing occurred at a median of 6 months (interquartile range, 6-12 months), a highly statistically significant difference (P < .001). In the second cohort without allogenic graft replacement, radiographic filling at the donor site was complete within a 12-month period. Tricortical bone can be successfully harvested from the calcaneus, but there may an associated risk of heel fracture. The role of replacement allogenic bone in assisting healing at the donor site is unclear. 相似文献
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The use of physical techniques such as scanning electron microscopyand microprobe analysis permits the analysis of valuable detailsof the structure of dried samples of mid-cycle cervical mucusduring the period of maximum ferning. From a crystallographicpoint of view, particular attention was paid to the location,morphology and chemical composition of anisotropic organic sulphatemicrostructures. As distinct from the isotropic sodium chloridepattern described by Papanicolaou, these appear in a narrowperiod of time corresponding to the middle of the period ofmaximum ferning. Anisotropic microstructures were revealed tobe tiny isolated crystals or polycrystalline aggregates composedof double salts of potassium and sodium. The potassium/sodiumcation ratio, equal to 3/1, was constant in the best specimens.Using a simple polarizing microscope, the detection of anisotropicmicrostructures may be useful to determine the period of maximumfertility more accurately. In addition, experiments have beencarried out in order to determine the relative importance ofsulphate anisotropic structures as compared with the whole crystallizedsurface and to investigate precisely their transience afterthey appear. 相似文献
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R Kettritz S Anders U Kettritz W Schneider U G?bel FC Luft 《American journal of kidney diseases》1998,31(5):860-862
We report the occurrence of spontaneous splenic hemorrhage in a patient with Wegener's granulomatosis. Pulmonary infiltrates, hemoptysis, and crescentic glomerulonephritis were accompanied by a progressive splenic enlargement with minimal abdominal symptoms. Magnetic resonance imaging was particularly helpful. The spleen was removed by minimally invasive endoscopic surgery. Subcapsular hemorrhage had occurred because of splenic vasculitis. Postoperatively, a remission was achieved by a combination of high-dose corticosteroids and cyclophosphamide. 相似文献
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