首页 | 本学科首页   官方微博 | 高级检索  
文章检索
  按 检索   检索词:      
出版年份:   被引次数:   他引次数: 提示:输入*表示无穷大
  收费全文   3148939篇
  免费   271616篇
  国内免费   13749篇
耳鼻咽喉   43667篇
儿科学   99823篇
妇产科学   81392篇
基础医学   507267篇
口腔科学   84177篇
临床医学   278266篇
内科学   555892篇
皮肤病学   85712篇
神经病学   272327篇
特种医学   125310篇
外国民族医学   361篇
外科学   496703篇
综合类   96705篇
现状与发展   23篇
一般理论   2167篇
预防医学   263750篇
眼科学   71109篇
药学   214222篇
  22篇
中国医学   9194篇
肿瘤学   146215篇
  2021年   54576篇
  2020年   34833篇
  2019年   57776篇
  2018年   70179篇
  2017年   53526篇
  2016年   59051篇
  2015年   73398篇
  2014年   107385篇
  2013年   172416篇
  2012年   83916篇
  2011年   82907篇
  2010年   114134篇
  2009年   119436篇
  2008年   70811篇
  2007年   72807篇
  2006年   83880篇
  2005年   79888篇
  2004年   81834篇
  2003年   73233篇
  2002年   63322篇
  2001年   89194篇
  2000年   81783篇
  1999年   84929篇
  1998年   63413篇
  1997年   61769篇
  1996年   59479篇
  1995年   54925篇
  1994年   49122篇
  1993年   45915篇
  1992年   58536篇
  1991年   55221篇
  1990年   52397篇
  1989年   51790篇
  1988年   48337篇
  1987年   47252篇
  1986年   45298篇
  1985年   45489篇
  1984年   43087篇
  1983年   39914篇
  1982年   39838篇
  1981年   37588篇
  1980年   35551篇
  1979年   35087篇
  1978年   32153篇
  1977年   29700篇
  1976年   27278篇
  1975年   25791篇
  1974年   26281篇
  1973年   25128篇
  1972年   23658篇
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
31.
32.
The coronavirus disease 2019 (COVID-19) pandemic has rapidly created widespread impacts on global health and the economy. Data suggest that women are less susceptible to severe illness. However, sex-disaggregated data are incomplete, leaving room for misinterpretation, and focusing only on biologic sex underestimates the gendered impact of the pandemic on women. This narrative review summarizes what is known about gender disparities during the COVID-19 pandemic and the economic, domestic, and health burdens along with overlapping vulnerabilities related to the pandemic. In addition, this review outlines recommended strategies that advocacy groups, community leaders, and policymakers should implement to mitigate the widening gender disparities related to COVID-19.  相似文献   
33.
34.
35.
The coronavirus 2019 pandemic has affected almost every aspect of health care delivery in the United States, and the emergency medicine system has been hit particularly hard while dealing with this public health crisis. In an unprecedented time in our history, medical systems and clinicians have been asked to be creative, flexible, and innovative, all while continuing to uphold the important standards in the US health care system. To continue providing quality services to patients during this extraordinary time, care providers, organizations, administrators, and insurers have needed to alter longstanding models and procedures to respond to the dynamics of a pandemic. The Emergency Medicine Treatment and Active Labor Act of 1986, or EMTALA, is 1 example of where these alterations have allowed health care facilities and clinicians to continue their work of caring for patients while protecting both the patients and the clinicians themselves from infectious exposures at the same time.  相似文献   
36.
Isolated patellofemoral arthritis is an increasingly recognized entity, and is usually associated with previous patellofemoral dysplasia or instability. Patellofemoral arthroplasty (PFA) has evolved significantly in recent years, both in terms of implant design and importantly in the understanding of appropriate patient selection. This review outlines the indications and investigations for PFA, provides a brief history of the development of contemporary implants, and presents the clinical outcomes for the prostheses most commonly used in the UK. In addition, it provides a detailed surgical technique for implantation of an onlay implant, with tips on how to optimize patellofemoral biomechanics and thus achieve a consistently good outcome.  相似文献   
37.
Immunoglobulin light chain amyloidosis (AL) commonly presents with nephrotic range proteinuria, heart failure with preserved ejection fraction, nondiabetic peripheral neuropathy, unexplained hepatomegaly or diarrhea, and should be considered in patients presenting with these symptoms. More importantly, patients being monitored for smoldering multiple myeloma and a monoclonal gammopathy of undetermined significance (MGUS) are at risk for developing AL amyloidosis. MGUS and myeloma patients that have atypical features, including unexplained weight loss; lower extremity edema, early satiety, and dyspnea on exertion should be considered at risk for light chain amyloidosis. Overlooking the diagnosis of light chain amyloidosis leading to therapy delay is common, and it represents an error of diagnostic consideration. Herein we provide a review of established and investigational treatments for patients with AL amyloidosis and provide algorithms for workup and management of these patients.Subject terms: Myeloma, Chemotherapy  相似文献   
38.
39.
Fibroblast growth factor receptors (FGFRs) are aberrantly activated through single-nucleotide variants, gene fusions and copy number amplifications in 5–10% of all human cancers, although this frequency increases to 10–30% in urothelial carcinoma and intrahepatic cholangiocarcinoma. We begin this review by highlighting the diversity of FGFR genomic alterations identified in human cancers and the current challenges associated with the development of clinical-grade molecular diagnostic tests to accurately detect these alterations in the tissue and blood of patients. The past decade has seen significant advancements in the development of FGFR-targeted therapies, which include selective, non-selective and covalent small-molecule inhibitors, as well as monoclonal antibodies against the receptors. We describe the expanding landscape of anti-FGFR therapies that are being assessed in early phase and randomised controlled clinical trials, such as erdafitinib and pemigatinib, which are approved by the Food and Drug Administration for the treatment of FGFR3-mutated urothelial carcinoma and FGFR2-fusion cholangiocarcinoma, respectively. However, despite initial sensitivity to FGFR inhibition, acquired drug resistance leading to cancer progression develops in most patients. This phenomenon underscores the need to clearly delineate tumour-intrinsic and tumour-extrinsic mechanisms of resistance to facilitate the development of second-generation FGFR inhibitors and novel treatment strategies beyond progression on targeted therapy.Subject terms: Cancer, Cancer  相似文献   
40.
设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号