全文获取类型
收费全文 | 924276篇 |
免费 | 66272篇 |
国内免费 | 4454篇 |
专业分类
耳鼻咽喉 | 12744篇 |
儿科学 | 28953篇 |
妇产科学 | 26372篇 |
基础医学 | 129202篇 |
口腔科学 | 25063篇 |
临床医学 | 78009篇 |
内科学 | 186294篇 |
皮肤病学 | 19260篇 |
神经病学 | 72831篇 |
特种医学 | 37504篇 |
外国民族医学 | 343篇 |
外科学 | 144787篇 |
综合类 | 24779篇 |
现状与发展 | 8篇 |
一般理论 | 248篇 |
预防医学 | 66585篇 |
眼科学 | 20668篇 |
药学 | 66839篇 |
20篇 | |
中国医学 | 3482篇 |
肿瘤学 | 51011篇 |
出版年
2019年 | 7279篇 |
2018年 | 9954篇 |
2017年 | 8041篇 |
2016年 | 8435篇 |
2015年 | 9909篇 |
2014年 | 13966篇 |
2013年 | 20734篇 |
2012年 | 27745篇 |
2011年 | 29535篇 |
2010年 | 18300篇 |
2009年 | 17169篇 |
2008年 | 27677篇 |
2007年 | 29291篇 |
2006年 | 29415篇 |
2005年 | 28715篇 |
2004年 | 27273篇 |
2003年 | 26567篇 |
2002年 | 25936篇 |
2001年 | 42032篇 |
2000年 | 43160篇 |
1999年 | 36693篇 |
1998年 | 10245篇 |
1997年 | 9372篇 |
1996年 | 9237篇 |
1995年 | 8584篇 |
1994年 | 8204篇 |
1993年 | 7656篇 |
1992年 | 28254篇 |
1991年 | 27044篇 |
1990年 | 26458篇 |
1989年 | 25392篇 |
1988年 | 23592篇 |
1987年 | 23194篇 |
1986年 | 22275篇 |
1985年 | 21167篇 |
1984年 | 15823篇 |
1983年 | 13479篇 |
1982年 | 8088篇 |
1979年 | 14589篇 |
1978年 | 10208篇 |
1977年 | 8627篇 |
1976年 | 8147篇 |
1975年 | 8959篇 |
1974年 | 10697篇 |
1973年 | 10182篇 |
1972年 | 9661篇 |
1971年 | 8917篇 |
1970年 | 8584篇 |
1969年 | 8025篇 |
1968年 | 7684篇 |
排序方式: 共有10000条查询结果,搜索用时 46 毫秒
61.
62.
63.
64.
65.
N. S. Hari Narayana Moorthy Sergio F. Sousa Maria J. Ramos Pedro A. Fernandes 《Medicinal chemistry research》2016,25(7):1340-1357
Farnesyltransferase (FTase) is one of the prenyltransferase family enzymes that catalyse the transfer of 15-membered isoprenoid (farnesyl) moiety to the cysteine of CAAX motif-containing proteins including Rho and Ras family of G proteins. Inhibitors of FTase act as drugs for cancer, malaria, progeria and other diseases. In the present investigation, we have developed two structure-based pharmacophore models from protein–ligand complex (3E33 and 3E37) obtained from the protein data bank. Molecular dynamics (MD) simulations were performed on the complexes, and different conformers of the same complex were generated. These conformers were undergone protein–ligand interaction fingerprint (PLIF) analysis, and the fingerprint bits have been used for structure-based pharmacophore model development. The PLIF results showed that Lys164, Tyr166, TrpB106 and TyrB361 are the major interacting residues in both the complexes. The RMSD and RMSF analyses on the MD-simulated systems showed that the absence of FPP in the complex 3E37 has significant effect in the conformational changes of the ligands. During this conformational change, some interactions between the protein and the ligands are lost, but regained after some simulations (after 2 ns). The structure-based pharmacophore models showed that the hydrophobic and acceptor contours are predominantly present in the models. The pharmacophore models were validated using reference compounds, which significantly identified as HITs with smaller RMSD values. The developed structure-based pharmacophore models are significant, and the methodology used in this study is novel from the existing methods (the original X-ray crystallographic coordination of the ligands is used for the model building). In our study, along with the original coordination of the ligand, different conformers of the same complex (protein–ligand) are used. It concluded that the developed methodology is significant for the virtual screening of novel molecules on different targets. 相似文献
66.
67.
F. Giovanardi F. Nudo Q. Lai M. Garofalo A. Consolo E. Choppin De Janvry G.A. Arroyo Murillo P. Ursi D. Stabile F. Melandro P.B. Berloco R. Pretagostini L. Poli 《Transplantation proceedings》2019,51(1):128-131
Background
Arterial vascular anomalies in patients undergoing kidney transplantation (KT) are correlated with a higher incidence of early surgical complications, potentially causing graft loss. Arterial reconstruction allows patients to overcome these surgical challenges, thus minimizing the risk of poor outcomes. The aim of the present study is to retrospectively investigate the safety and effectiveness of the multiple arterial reconstruction technique with a Teflon patch in case of an unavailable aortic patch: to do so, surgical complications, graft function, and patient survival were evaluated.Methods
During the period January 2009 to August 2016, 202 adult deceased-donor KTs were performed at our center. Group A (n = 27; reconstruction of multiple arteries) and Group B (n = 175; control group) were compared.Results
No differences were observed between the 2 groups in terms of early postoperative course, with no vascular complication observed in Group A. No vascular patch infections were reported, nor longer cold ischemia time rates. Similarly, long-term survival rates were similar between the 2 groups.Conclusions
The Teflon-patch arterial reconstruction technique appears to be safe and effective, with an acceptable balance of benefits and potential risks of using a prosthetic material. Studies based on larger series are needed to further validate this approach. 相似文献68.
Shengxuan Cao Chen Wang Xin Ma Xu Wang Jiazhang Huang Chao Zhang Li Chen Xiang Geng Kan Wang 《Journal of orthopaedic research》2019,37(8):1860-1867
Patients with mechanic ankle instability experience increased tibiotalar and subtalar joint laxity. However, in vivo joint kinematics in functional ankle instability (FAI) patients and lateral ankle sprain (LAS) copers, especially during dynamic activities, are poorly understood. Ten FAI patients, 10 LAS copers, and 10 healthy controls were included in this study. A dual fluoroscopic imaging system was used to analyze the tibiotalar and subtalar joint kinematics during stair descent. Five key poses of stair descent were analyzed. Kinematic data from six degrees of freedom were calculated utilizing a solid modeling software. The range of motion and joint positions in each degree of freedom were compared among the three groups. The tibiotalar joints of FAI patients and LAS copers were significantly more inverted than those of healthy controls during the foot strike (p = 0.016, = 0.264). The subtalar joints of FAI patients were significantly more anteriorly translated (pose 2, p = 0.003, = 0.352; pose 3, p < 0.001, = 0.454; pose 4, p = 0.004, = 0.334), inverted (pose 4, p = 0.027, = 0.234; pose 5,p = 0.034, = 0.221), and externally rotated (pose 4, p = 0.037, = 0.217; pose 5; p = 0.004, = 0.331) than those of healthy controls during the mid‐stance and the heel off. The FAI patients showed excessive tibiotalar inversion and subtalar joint hypermobility during stair descent. Meanwhile, the LAS copers maintained subtalar joint stability, and only showed excessive tibiotalar inversion in foot strike. These data provide insight into the mechanisms behind the development of FAI after initial LAS. © 2019 Orthopaedic Research Society. Published by Wiley Periodicals, Inc. J Orthop Res 37:1860–1867, 2019 相似文献
69.
70.