全文获取类型
收费全文 | 5001篇 |
免费 | 445篇 |
国内免费 | 64篇 |
专业分类
耳鼻咽喉 | 96篇 |
儿科学 | 84篇 |
妇产科学 | 100篇 |
基础医学 | 628篇 |
口腔科学 | 27篇 |
临床医学 | 485篇 |
内科学 | 1231篇 |
皮肤病学 | 60篇 |
神经病学 | 337篇 |
特种医学 | 158篇 |
外科学 | 1032篇 |
综合类 | 74篇 |
一般理论 | 1篇 |
预防医学 | 379篇 |
眼科学 | 83篇 |
药学 | 368篇 |
中国医学 | 7篇 |
肿瘤学 | 360篇 |
出版年
2023年 | 77篇 |
2022年 | 104篇 |
2021年 | 244篇 |
2020年 | 119篇 |
2019年 | 202篇 |
2018年 | 232篇 |
2017年 | 137篇 |
2016年 | 137篇 |
2015年 | 164篇 |
2014年 | 215篇 |
2013年 | 256篇 |
2012年 | 406篇 |
2011年 | 413篇 |
2010年 | 228篇 |
2009年 | 201篇 |
2008年 | 283篇 |
2007年 | 313篇 |
2006年 | 275篇 |
2005年 | 262篇 |
2004年 | 256篇 |
2003年 | 212篇 |
2002年 | 183篇 |
2001年 | 28篇 |
2000年 | 26篇 |
1999年 | 36篇 |
1998年 | 38篇 |
1997年 | 53篇 |
1996年 | 28篇 |
1995年 | 30篇 |
1994年 | 18篇 |
1993年 | 15篇 |
1992年 | 19篇 |
1991年 | 15篇 |
1990年 | 15篇 |
1989年 | 14篇 |
1988年 | 9篇 |
1987年 | 20篇 |
1986年 | 19篇 |
1985年 | 11篇 |
1984年 | 12篇 |
1983年 | 9篇 |
1982年 | 14篇 |
1981年 | 17篇 |
1979年 | 10篇 |
1978年 | 11篇 |
1977年 | 8篇 |
1976年 | 7篇 |
1975年 | 8篇 |
1974年 | 8篇 |
1959年 | 6篇 |
排序方式: 共有5510条查询结果,搜索用时 15 毫秒
91.
James R. Brown Evan D. Holloway Tohoro F. Akakpo Matthew C. Aalsma 《Community mental health journal》2014,50(2):193-203
A strong therapeutic alliance has been shown to improve mental health treatment outcomes in adults, but this topic has not been fully explored with youth. Adolescents, particularly justice-involved youth, stand to benefit greatly from an improved treatment experience. One quality which can improve treatment is mental health providers’ interpersonal skills when attempting to build a therapeutic rapport with adolescent clients. Semi-structured interviews were conducted with 19 youth who screened positive for mental health concerns while in juvenile detention. Four themes were identified as important to improving the therapeutic alliance: Empathy, client-directed care, sequencing, and positive rapport. Suggestions for strengthening a therapeutic alliance are provided. 相似文献
92.
93.
94.
95.
96.
Jessica Ayers Jamie Cook Rachel A. Koenig Evan M. Sisson Dave L. Dixon 《Current atherosclerosis reports》2018,20(6):29
Purpose of Review
This review examines recent randomized clinical trials evaluating the role of coenzyme Q10 (CoQ10) in the management of coronary heart disease.Recent Findings
CoQ10 is one of the most commonly used dietary supplements in the USA. Due to its antioxidant and anti-inflammatory effects, CoQ10 has been studied extensively for possible use in managing coronary heart disease. One of the most common applications of CoQ10 is to mitigate statin-associated muscle symptoms (SAMS) based on the theory that SAMS are caused by statin depletion of CoQ10 in the muscle. Although previous studies of CoQ10 for SAMS have produced mixed results, CoQ10 appears to be safe. Because CoQ10 is a cofactor in the generation of adenosine triphosphate, supplementation has also recently been studied in patients with heart failure, which is inherently an energy deprived state. The Q-SYMBIO trial found that CoQ10 supplementation in patients with heart failure not only improved functional capacity, but also significantly reduced cardiovascular events and mortality. Despite these positive findings, a larger prospective trial is warranted to support routine use of CoQ10. Less impressive are the effects of CoQ10 on specific cardiovascular risk factors such as blood pressure, dyslipidemia, and glycemic control.Summary
Current evidence does not support routine use of CoQ10 in patients with coronary heart disease. Additional studies are warranted to fully determine the benefit of CoQ10 in patients with heart failure before including it in guideline-directed medical therapy.97.
Incidence, predictors at admission, and impact of worsening renal function among patients hospitalized with heart failure 总被引:10,自引:0,他引:10
Forman DE Butler J Wang Y Abraham WT O'Connor CM Gottlieb SS Loh E Massie BM Rich MW Stevenson LW Young JB Krumholz HM 《Journal of the American College of Cardiology》2004,43(1):61-67
OBJECTIVES: The goal of this study was to determine the prevalence of worsening renal function (WRF) among hospitalized heart failure (HF) patients, clinical predictors of WRF, and hospital outcomes associated with WRF. BACKGROUND: Impaired renal function is associated with poor outcomes among chronic HF patients. METHODS: Chart reviews were performed on 1,004 consecutive patients admitted for a primary diagnosis of HF from 11 geographically diverse hospitals. Cox regression model analysis was used to identify independent predictors for WRF, defined as a rise in serum creatinine of >0.3 mg/dl (26.5 micromol/l). Bivariate analysis was used to determine associations of development of WRF with outcomes (in-hospital death, in-hospital complications, and length of stay). RESULTS: Among 1,004 HF patients studied, WRF developed in 27%. In the majority of cases, WRF occurred within three days of admission. History of HF or diabetes mellitus, admission creatinine > or =1.5 mg/dl (132.6 micromol/l), and systolic blood pressure >160 mm Hg were independently associated with higher risk of WRF. A point score based on these characteristics and their relative risk ratios predicted those at risk for WRF. Hospital deaths (adjusted risk ratio [ARR] 7.5; 95% confidence intervals [CI] 2.9, 19.3), complications (ARR 2.1; CI 1.5, 3.0), and length of hospitalizations >10 days (ARR 3.2, CI 2.2, 4.9) were greater among patients with WRF. CONCLUSIONS: Worsening renal function occurs frequently among hospitalized HF patients and is associated with significantly worse outcomes. Clinical characteristics available at hospital admission can be used to identify patients at increased risk for developing WRF. 相似文献
98.
Charles L Bennett Benjamin Kim Anaadriana Zakarija Nicholas Bandarenko Dilip K Pandey Charlie G Buffie June M McKoy Amul D Tevar John F Cursio Paul R Yarnold Hau C Kwaan Davide De Masi Ravindra Sarode Thomas J Raife Joseph E Kiss Dennis W Raisch Charles Davidson J Evan Sadler Thomas L Ortel X Long Zheng Seiji Kato Masanori Matsumoto Masahito Uemura Yoshihiro Fujimura 《Journal of the American College of Cardiology》2007,50(12):1138-1143
OBJECTIVES: We sought to describe clinical and laboratory findings for a large cohort of patients with thienopyridine-associated thrombotic thrombocytopenic purpura (TTP). BACKGROUND: The thienopyridine derivatives, ticlopidine and clopidogrel, are the 2 most common drugs associated with TTP in databases maintained by the U.S. Food and Drug Administration (FDA). METHODS: Clinical reports of TTP associated with clopidogrel and ticlopidine were identified from medical records, published case reports, and FDA case reports (n = 128). Duration of thienopyridine exposure, clinical and laboratory findings, and survival were recorded. ADAMTS13 activity (n = 39) and inhibitor (n = 30) were measured for a subset of individuals. RESULTS: Compared with clopidogrel-associated TTP cases (n = 35), ticlopidine-associated TTP cases (n = 93) were more likely to have received more than 2 weeks of drug (90% vs. 26%), to be severely thrombocytopenic (84% vs. 60%), and to have normal renal function (72% vs. 45%) (p < 0.01 for each). Compared with TTP patients with ADAMTS13 activity >15% (n = 13), TTP patients with severely deficient ADAMTS13 activity (n = 26) were more likely to have received ticlopidine (92.3% vs. 46.2%, p < 0.003). Among patients who developed TTP >2 weeks after thienopyridine, therapeutic plasma exchange (TPE) increased likelihood of survival (84% vs. 38%, p < 0.05). Among patients who developed TTP within 2 weeks of starting thienopyridines, survival was 77% with TPE and 78% without. CONCLUSIONS: Thrombotic thrombocytopenic purpura is a rare complication of thienopyridine treatment. This drug toxicity appears to occur by 2 different mechanistic pathways, characterized primarily by time of onset before versus after 2 weeks of thienopyridine administration. If TTP occurs after 2 weeks of ticlopidine or clopidogrel therapy, therapeutic plasma exchange must be promptly instituted to enhance likelihood of survival. 相似文献
99.
100.
Chang Joy W. Rubenstein Joel H. Mellinger Jessica L. Kodroff Ellyn Strobel Mary J. Scott Melissa Mack Denise Book Wendy Sable Kathleen Kyle Scholeigh Paliana Allisa Dellon Evan S. 《Digestive diseases and sciences》2021,66(6):1808-1817
Digestive Diseases and Sciences - Little is known about patient choice in treatment of eosinophilic esophagitis (EoE). Determine motivators and barriers to using common EoE therapies and describe... 相似文献