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961.
Lesley A. Inker Morgan E. Grams Andrew S. Levey Josef Coresh Massimo Cirillo John F. Collins Ron T. Gansevoort Orlando M. Gutierrez Takayuki Hamano Gunnar H. Heine Shizukiyo Ishikawa Sun Ha Jee Florian Kronenberg Martin J. Landray Katsuyuki Miura Girish N. Nadkarni Carmen A. Peralta Dietrich Rothenbacher Mark Woodward 《American journal of kidney diseases》2019,73(2):206-217
962.
Summary. We have analysed the sequence variability of the banana bunchy top nanovirus (BBTV) DNA-1 sequence from 17 isolates collected
throughout Vietnam, and showed that the level of DNA-1 sequence variation within Vietnam was approximately double that previously
reported for Asian BBTV isolates. Furthermore, the sequences separated into two geographical subgroups that generally correlated
to the northern or southern regions of Vietnam. We have also characterised an additional putative Rep-encoding component associated
with some BBTV isolates from Vietnam. This component, which we have named BBTV-S3, shared 47%, 69%, 56% and 65% nucleotide
sequence identity with the previously reported Rep-encoding components BBTV DNA-1, S1, S2 and Y1 respectively.
Received September 14, 2001 Accepted December 20, 2001 相似文献
963.
Se Ik Kim Ji Hyun Kim Cheol Lee Johyun Ha Kyu-Won Jung Myong Cheol Lim 《Journal Of Gynecologic Oncology》2023,34(1)
ObjectiveTo investigate the incidence and survival rates of primary uterine carcinosarcoma (UCS) in Korea.MethodsFrom the Korea Central Cancer Registry, we identified patients diagnosed with primary UCS between 1999 and 2018 and collected their information, including age at diagnosis, Surveillance, Epidemiology, and End Results (SEER) summary stage, and treatment. Age-standardized incidence rates (ASRs) and annual percent changes (APCs) were calculated. Baseline characteristics and overall survival (OS) were compared by study periods, ages, and stages at initial diagnosis.ResultsOverall, the incidence rate of primary UCS increased markedly during the time period: ASRs, 0.02 per 100,000 in 1999 and 0.25 per 100,000 in 2018 (APC, 13.9%; p<0.001). No difference in OS was observed between patients diagnosed in 1999–2008 and those diagnosed in 2009–2018 (5-year survival rate, 46.0% vs. 48.6%; p=0.871). Considering the mean patient age at diagnosis of UCS, we divided the study population into 2 groups. Patients aged ≥60 years had a more frequent prior radiation history, received less multi-modality treatment, and showed worse OS than those aged <60 years (5-year survival rate, 42.7% vs. 53.6%; p=0.001). In multivariate analysis, both old age at diagnosis (≥60 years) and the SEER summary stage were identified as independent poor prognostic factors for OS, whereas radiation history before the diagnosis of UCS was not.ConclusionThe incidence rate of UCS in Korea increased significantly from 1999 to 2018. Advanced stage and old age (≥60 years) at diagnosis might be poor prognostic factors for survival, but not prior radiation history. 相似文献
964.
Jae Hui Kim Se Woong Kang Min Gui Kong Hyo Shin Ha 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2013,251(4):1055-1064
Background
To evaluate the changes in visual acuity, metamorphopsia, and thickness of retinal layers after epiretinal membrane (ERM) removal and to investigate factors associated with visual function.Methods
This prospective study included 52 eyes of 52 patients who underwent surgery for idiopathic ERM. Changes in visual acuity, metamorphopsia score (M-score) using M-chart, and parafoveal thickness of each retinal layer were evaluated preoperatively and at 2-month and 6-month postoperative follow-up visits. Factors associated with visual acuity and M-score were investigated.Results
Although continuous improvement in visual acuity and decrease in the thickness of parafoveal retinal layers following ERM removal was observed, relatively slow improvement in M-score was noted with values of 0.32?±?0.27, 0.44?±?0.46, and 0.23?±?0.23, respectively at the defined time points. A preoperative increase in the thickness of parafoveal retina was mainly caused by increased thickness of inner retinal layers. Preoperative thickness of inner nuclear layer (INL) were closely associated with preoperative, postoperative visual acuity, and preoperative M-score (p?=?0.001, 0.012, and 0.027, respectively).Conclusions
Compared with the postoperative improvement in visual acuity, the postoperative improvement in metamorphopsia was a rather slow process. Parafoveal INL thickness was found to be a significant structural factor for visual acuity and metamorphopsia in ERM. 相似文献965.
An analysis of 4,514 cases of renal biopsy in Korea 总被引:7,自引:0,他引:7
Choi IJ Jeong HJ Han DS Lee JS Choi KH Kang SW Ha SK Lee HY Kim PK 《Yonsei medical journal》2001,42(2):247-254
To evaluate the distribution and changing patterns of renal diseases in Korea, a total of 4,514 cases of renal biopsy collected over a 23-year period between 1973 and 1995 were reviewed. Of 4,200 cases excluding 314 unsatisfactory biopsies, adult cases comprised 59.5% and pediatric cases, 40.5%. The male to female ratio was 1.5:1 in adults and 2.2:1 in children. Glomerulonephritis (GN) comprised 80.0% of the total. The most common primary GN in adults was minimal change disease (MCD) (26.6%), followed by IgA nephropathy (IgAN) (22.1%), membranous GN (MGN) (11.8%), and membranoproliferative GN (MPGN) (5.9%). In children, the primary GN incidence rates were MCD (24.8%), IgAN (10.3%), poststreptococcal (including postinfectious) GN (PSGN) (8.6%), and focal segmental glomerulosclerosis (FSGS) (4.0%). The most common secondary GN in adults was lupus nephritis and in children Henoch-Schonlein purpura nephritis. The most common cause of nephrotic syndrome was MCD in both adults and children, followed by MGN and FSGS. The elderly, aged sixty years and older, comprised 2.7% of cases and recorded equal numbers of MCD and MGN. The proportion of the biopsies found to be seropositive for HBs antigen was 27.9%, and these showed either MGN or MPGN pattern. Repeat biopsy was performed in 168 patients, due to previous biopsy failure in 15.5%. When the primary GN cases were analyzed at 5-year intervals, the prevalence of PSGN, which was greater than 25% during the 1973-1982 period, decreased abruptly in children thereafter, whereas the prevalence of FSGS increased slowly since the 1988-1992 period in both adults and children. The decrease of PSGN and the increase of FSGS suggest a role for socioeconomic and environmental factors in Korea. 相似文献
966.
Victoria L. Fields Ian T. Kracalik Christina Carthel Adriana Lopez Amy Schwartz Nathaniel M. Lewis Mackenzie Bray Carlene Claflin Kilee Jorgensen Ha Khong Walter Richards Ilene Risk Maureen Smithee Madison Clawson Lee Cherie Booth Tara Scribellito Jason Lowry Jessica Huynh Linda Davis Holly Birch Tiffany Tran Joseph Walker Alicia Fry Aron Hall Jodee Baker Eric Pevzner Angela C. Dunn Jacqueline E. Tate Hannah L. Kirking Tair Kiphibane Cuc H. Tran 《Emerging infectious diseases》2021,27(12):2999
Outcomes and costs of coronavirus disease (COVID-19) contact tracing are limited. During March–May 2020, we constructed transmission chains from 184 index cases and 1,499 contacts in Salt Lake County, Utah, USA, to assess outcomes and estimate staff time and salaries. We estimated 1,102 staff hours and $29,234 spent investigating index cases and contacts. Among contacts, 374 (25%) had COVID-19; secondary case detection rate was ≈31% among first-generation contacts, ≈16% among second- and third-generation contacts, and ≈12% among fourth-, fifth-, and sixth-generation contacts. At initial interview, 51% (187/370) of contacts were COVID-19–positive; 35% (98/277) became positive during 14-day quarantine. Median time from symptom onset to investigation was 7 days for index cases and 4 days for first-generation contacts. Contact tracing reduced the number of cases between contact generations and time between symptom onset and investigation but required substantial resources. Our findings can help jurisdictions allocate resources for contact tracing. 相似文献
967.
Sung Hee Lim Jina Yun Min-Young Lee Han Jo Kim Kyoung Ha Kim Se Hyung Kim Sang-Chul Lee Sang Byung Bae Chan Kyu Kim Namsu Lee Kyu Taek Lee Seong Kyu Park Yun Nah Lee Jong Ho Moon 《Yonsei medical journal》2021,62(8):671
PurposeErlotinib has been the only targeted agent to show significantly improved outcomes in pancreatic adenocarcinoma when combined with gemcitabine. We aimed to evaluate whether the addition of oxaliplatin to a combination gemcitabine/erlotinib treatment conferred a clinical benefit in patients with locally advanced unresectable or metastatic pancreatic cancer.Materials and MethodsChemotherapy-naïve patients with locally advanced or metastatic pancreatic cancer were randomly assigned to receive GEMOX-T [gemcitabine 1000 mg/m2 and oxaliplatin 50 mg/m2 on day 1 (D1) and D8 plus erlotinib 100 mg daily for 3 weeks] or GT (gemcitabine 1000 mg/m2 on D1 and D8 plus erlotinib 100 mg daily for 3 weeks). The primary endpoint was the overall response rate (ORR).ResultsBetween 2013 and 2016, 65 patients were assigned to a treatment group (33 in the GEMOX-T arm, 32 in the GT arm). The ORR was 18.2% [95% confidence interval (CI), 8.82–27.58] in the GEMOX-T arm and 6.2% (95% CI, 0.34–12.06) in the GT arm (p=0.051). The disease control rate was significantly superior in the GEMOX-T arm compared to the GT arm (72.7% vs. 43.8%, p=0.019). After a median follow-up of 19.7 months, the median progression-free survival (PFS) was 3.9 months for the GEMOX-T arm and 1.4 months for the GT arm (p=0.033). However, this did not translate to an improvement in overall survival. The most common grade 3 or higher hematologic adverse events were neutropenia (16.9%) and anemia (13.8%).ConclusionThe addition of oxaliplatin to a first-line gemcitabine/erlotinib regimen demonstrated higher response rates and significantly improved PFS in patients with locally advanced or metastatic pancreatic cancer. 相似文献
968.
高效液相色谱法测定人血清中伊曲康唑浓度 总被引:1,自引:0,他引:1
目的:本文建立了HPLC法测定血清样品中伊曲康唑的定量分析方法。方法:色谱条件:以ZORBAXTM- C18(5μm ,4-6×150mm) 为色谱柱;乙晴- 水(67-5∶32-5V/V) 为流动相,检测波长263nm ;用正庚烷:异戊醇(98-5∶1-5V/V) 作为提取液。结果:3 种浓度40、80、300ng·ml-1 回收率分别为105-05% 、100-57 % 、97-91% ( n = 6) ;日内、日间RSD 分别为3-83% 、4-05% 、3-09 % 及6-00% 、4-90 % 、4-72% ( n = 6),血清中药物的最低检测浓度为5ng·ml- 1,在5 ~600ng·ml-1 血药浓度范围内线性关系良好,r =0-9995。结论:本方法灵敏、准确、结果令人满意,适用于临床血药浓度监测 相似文献
969.
乙型肝炎病毒基因的整合机制及对宿主的影响 总被引:1,自引:0,他引:1
乙型肝炎病毒是导致慢性肝炎、肝纤维化、肝细胞癌的主要病因,目前认为乙型肝炎病毒基因整合在其致病机制中具有重要作用,本文试就该领域内目前研究成果做一综述. 相似文献
970.
Sang Kyung Jung Kyung-Ah Kim So Young Ha Hyun Kyo Lee Young Doo Kim Bu Hyun Lee Woo Hyun Paik Jong Wook Kim Won Ki Bae Nam-Hoon Kim June Sung Lee Yoon Jung Jwa 《Clinical and molecular hepatology》2015,21(1):41-48