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991.
992.
Magnesium-based alloys are attractive as hydrogen storage materials due to their lightweight and high absorption, but their high operating temperatures and very slow kinetics are obstacles to practical applications. Therefore, the effect of CaO has improved the hydrogenation kinetics and slowed down the degradation. The Mg2NiHx–CaO composites were prepared by hydrogen-induced mechanical alloying (HIMA). Hydrogenation kinetics was performed by using an Automatic PCT Measuring System and evaluated in the temperature range of 423, 523, and 623 K. As a result of calculating the hydrogen absorption amounts through the hydrogenation kinetics curve, they were calculated as about 0.52 wt%, 1.21 wt%, and 1.59 wt% (Mg2NiHx–10 wt% CaO). In this study, the material environmental aspects of Mg2NiHx–CaO composites were investigated through life cycle assessment (LCA). LCA was performed analyzing the environmental impact characteristics of the manufacturing process by using Gabi software and the Eco-Indicator 99’ and Centrum voor Milieuweten schappen (CML 2001) methodology. As a result, the contents of global warming potential (GWP) and fossil fuels were found to have a higher impact than other impact categories. 相似文献
993.
Koki Chiba Hiroshi Nomoto Akinobu Nakamura Kyu Yong Cho Kumiko Yamashita Yui Shibayama Aika Miya Hiraku Kameda Yoshio Kurihara Shin Aoki Tatsuya Atsumi Hideaki Miyoshi 《Journal of diabetes investigation.》2021,12(2):176-183
Aims/IntroductionSodium–glucose cotransporter 2 inhibitors (SGLT2i) are used worldwide because of their multiple benefits for patients with type 2 diabetes. The purpose of this study was to determine the efficacy and safety of SGLT2i in patients with type 1 diabetes.Materials and MethodsPatients with type 1 diabetes who had been treated with SGLT2i for >12 weeks were included in this retrospective observation study. We recorded the changes in body mass, insulin dose, blood and urine test data, and adverse events. The changes in day‐to‐day glucose variability, as the primary end‐point, was evaluated using the interquartile range (P25/P75) of the ambulatory glucose data obtained using continuous glucose monitoring.ResultsA total of 51 patients (37 women; mean age 52.7 years) were included. Glycated hemoglobin and body mass significantly decreased by 0.4% and 1.6 kg, respectively. The total required insulin dose decreased by 9.4% (42.7 ± 26.6–38.7 ± 24.3 units/day). Continuous glucose monitoring data were obtained from 30 patients. P25/P75 decreased by 17.6 ± 20.7% during SGLT2i treatment (P < 0.001). The percentage of time per day within the target glucose range of 70–180 mg/dL significantly increased (from 42.2 to 55.5%, P < 0.001), without an increase in the percentage of time spent in the hypoglycemic range (<70 mg/dL). Urinary ketone bodies were detected in four patients (7.8%), but none developed ketoacidosis.ConclusionsSGLT2i improved day‐to‐day glucose variability and time in the target glucose range, without increasing frequency of hypoglycemia, in patients with type 1 diabetes, and reduced glycated hemoglobin, body mass and the required insulin dose. 相似文献
994.
Yuichiro Yamada Tatsuhito Himeno Kotaro Tsuboi Yuka Shibata Miyuka Kawai Yuriko Asada-Yamada Yusuke Hayashi Emi Asano-Hayami Tomohide Hayami Yuichiro Ishida Yohei Ejima Mikio Motegi Saeko Asano Makoto Kato Eriko Nagao Hiromi Nakai-Shimoda Takahiro Ishikawa Yoshiaki Morishita Masaki Kondo Shin Tsunekawa Yoshiro Kato Takayuki Nakayama Motohiro Kamei Jiro Nakamura Hideki Kamiya 《Journal of diabetes investigation.》2021,12(8):1430-1441
995.
996.
Seong Mi Moon Jun Hyeok Lim Yun Soo Hong Kyeong-Cheol Shin Chang Youl Lee Do Jin Kim Sang Haak Lee Ki Suck Jung Chang-Hoon Lee Kwang Ha Yoo Hyun Lee Hye Yun Park 《Journal of thoracic disease》2021,13(2):837
BackgroundForced vital capacity (FVC) has been suggested to be a good biomarker for decreased exercise performance in patients with chronic obstructive pulmonary disease (COPD). However, as FVC is highly correlated with forced expiratory volume in 1 second (FEV1), the relationship between FVC and exercise capacity should be assessed within the category of FEV1, i.e., COPD severity. However, this was not considered in previous studies. Thus, limited data are available on the association between reduced FVC and exercise capacity measured by 6-min walk distance (6MWD) based on COPD severity.MethodsWe performed a cross-sectional study using data from the Korean COPD Subgroup Study (KOCOSS) cohort. We evaluated 1,386 patients with moderate (n=895) and severe-to-very severe (n=491) COPD. Reduced FVC was defined as FVC <80% predicted and short 6MWD as <350 m. Multivariable logistic regression was used to evaluate the association between reduced FVC and short 6MWD.ResultsThere were no significant differences in respiratory symptoms and quality of life between the patients with reduced FVC and those with preserved FVC. However, patients with reduced FVC had shorter 6MWD (30.5 cm in moderate and 34.5 cm in severe-to-very severe COPD) and higher BODE index scores than those with preserved FVC. The cubic spline model revealed 6MWD peaked around 93% predicted of FVC in moderate COPD, whereas FVC showed a positive association with 6MWD in severe-to-very severe COPD. Multivariable analyses showed that reduced FVC was significantly associated with short 6MWD in both moderate [adjusted odds ratio (aOR) =1.44, 95% confidence interval (CI): 1.03–2.02] and severe-to-very severe (adjusted OR =1.55, 95% CI: 1.01–2.40) COPD.ConclusionsReduced FVC was significantly associated with shorter 6MWD in moderate-to-very severe COPD patients, suggesting that reduced FVC might be reflective of 6MWD-measured exercise capacity in moderate-to-very severe COPD. 相似文献
997.
998.
Park Ji Yong Choi Wonsuk Hong A Ram Yoon Jee Hee Kim Hee Kyung Jang Woo-Youl Jung Shin Kang Ho-Cheol 《Pituitary》2021,24(6):955-963
Pituitary - Dopamine agonists (DAs) have long been the recommended first-line treatment for prolactinoma. Given the remarkable developments in surgical techniques, however, surgery is on the rise.... 相似文献
999.
Matsuda Yasuhiro Masuda Masaharu Asai Mitsutoshi Iida Osamu Okamoto Shin Ishihara Takayuki Nanto Kiyonori Kanda Takashi Tsujimura Takuya Okuno Shota Hata Yosuke Uematsu Hiroyuki Mano Toshiaki 《Journal of interventional cardiac electrophysiology》2021,61(1):171-179
Journal of Interventional Cardiac Electrophysiology - Cardiac conduction disturbance necessitating pacemaker implantation is common among elderly patients. However, patients often have... 相似文献
1000.