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81.
Essam El-Hinnawi 《Australasian physical & engineering sciences in medicine / supported by the Australasian College of Physical Scientists in Medicine and the Australasian Association of Physical Sciences in Medicine》2010,33(4):369-369
Reviewers
Acknowledgement of reviewers for volume 33 相似文献82.
Perioperative Liver Function after Hepatectomy in a Tertiary University Hospital in Damascus 下载免费PDF全文
Basel AhmadKhaled TurkmaniMohamad Essam MarwaTareq AhmadRamez BaghdadiShaimaa AboudamaahKhetam Alkhatib Mohamad Ahmad 《Asian Pacific journal of cancer prevention》2017,18(8):2109-2113
Background: Liver resection is the only viable therapeutic treatment option for several neoplastic entities of the liver. Although, the number of resectable patients is increasing in Syria, liver failure is still a major complication affecting mortality and morbidity rates. Methods: Between 2009 and 2016, 104 patients undergoing liver resection in Damascus University Faculty of Medicine were retrospectively analyzed. Liver function tests were conducted before surgery (ps) and in the perioperative period (po) and comparisons were performed with division into anatomic VS non-anatomic or malignant VS non-malignant groups. Results: Liver synthetic, excretory and detoxifying functions deteriorated after liver resection (INR ps ‘presurgery’=1.129 po ‘perioperative’=1.426 P<0.001, TP ps=7.426 po=5.581 P<0.001, ALB ps=4.204 po=3.242 P<0.001, T-Bill ps=0.061 po=0.136 P<0.001) and liver cell necrosis increased after resection (ALT ps=27.597 po=200.221 P<0.001, AST ps=33.395 po=190.553 P<0.001). There was no significant difference in liver functions when we compared anatomic VS non-anatomic groups or malignant VS non-malignant groups, but liver cell necrosis was higher with malignancies (ALT malignant group=236.475 non-malignant group=89.5 P=0.002, AST malignant group=222.644 non-malignant group=101.125 P=0.001). Conclusion: Although liver resection affects liver function significantly, no differences in outcomes were found between anatomic VS non anatomic or malignant VS non-malignant groups. 相似文献
83.
We present a case of solitary eosinophilic granuloma in the skull of a 6-year-old Saudi boy. This osteolytic lesion has fluid-fluid level on CT and MRI. We are presenting a rare radiological finding of eosinophilic granuloma. 相似文献
84.
Hathout E Alonso E Anand R Martz K Imseis E Johnston J Lopez J Chinnock R McDiarmid S;SPLIT study group 《Pediatric transplantation》2009,13(5):599-605
Abstract: To determine the characteristics of pediatric liver transplant recipients who develop GI and/or PTDM, data on children undergoing their first liver transplant from the SPLIT database were analyzed (n = 1611). Recipient and donor characteristics that were evaluated included age at transplant, gender, race, primary disease, hospitalization status at transplant, BMI, recipient and donor CMV status, donor type, donor age, and primary immunosuppression. GI/PTDM was found in 214 individuals (13%) of whom 166 (78%) were diagnosed within 30 days of transplantation (early GI/PTDM). Multivariate analyses suggests that age >5 yr at transplant, hospitalization at transplant, a primary diagnosis other than BA, early steroid use, and tacrolimus use are associated with increased incidence of early GI. Routine monitoring for the development of GI and post-transplant diabetes is indicated in the short- and long-term care of children after liver transplantation. 相似文献
85.
86.
Perry J Ghazaly E Kitromilidou C McGrowder EH Joel S Powles T 《Molecular cancer therapeutics》2010,9(12):3322-3329
Lapatinib is a specific HER1 and 2 targeted tyrosine kinase inhibitor now widely used in combination with chemotherapy in the clinical setting. In this work, we investigated the interactions between lapatinib and specific chemotherapy agents (cisplatin, SN-38, topotecan) in a panel of cell lines [breast (n = 2), lung (n = 2), testis (n = 4)]. A high-sensitivity cell proliferation/cytotoxicity ATP assay and flow cytometry were used to determine cell viability, apoptosis, and the effect of the drugs on cell-cycle distribution. CalcuSyn analysis was employed to formally identify synergistic interactions between drugs. Intracellular concentrations of SN-38 were measured using a novel high-performance liquid chromatography (HPLC) technique. Flow cytometry and HPLC techniques were used to identify the effect of lapatinib on drug influx and efflux pumps, using specific substrates and inhibitors of these pumps. Results showed significant synergy between SN-38, and lapatinib in the majority of cell lines (combination index < 0.75), associated with increased apoptosis. This synergy was not universal but, when observed (Susa S/R, H1975, H358, and MDA-MB-231 cell lines), was related to SN-38 intracellular accumulation (2.2- to 4.8-fold increase, P < 0.05 for each), attributable to the inhibition of the breast cancer-related protein (BCRP) efflux pump by lapatinib. Flow cytometry analysis showed that lapatinib (10 μmol/L) inhibited the efflux of mitoxantrone, a specific substrate of the BCRP pump, in a manner similar to fumitremorgin C, a known BCRP inhibitor, confirming lapatinib as a BCRP inhibitor. This work shows that lapatinib has a direct inhibitory effect on BCRP accounting for the synergistic findings. The synergy is cell line dependent and related to the activity of specific efflux pumps. 相似文献
87.
J. A. Kari Hussain Bamashmous Sattam Lingawi Essam Al-Sabban Mohammed Akhtar 《Pediatric nephrology (Berlin, Germany)》2001,16(11):894-897
A case of infantile nephrotic syndrome (NS) with advanced membranoproliferative glomerulonephritis (MPGN), type I, and bilateral
congenital glaucoma, is presented. The patient also had persistent thrombocytopenia and subclinical hypothyroidism. The parents
were second-degree cousins and the affected infant had a sibling who was born with congenital glaucoma. His mother had an
aunt and uncle on the maternal side who were born with congenital glaucoma. In addition, there was a history of infantile
death in five family members of unknown causes (pedigree). To the best of our knowledge, the association of congenital glaucoma
and infantile NS due to MPGN has not been reported previously.
Received: 19 February 2001 / Revised: 30 May 2001 / Accepted: 31 May 2001 相似文献
88.
Ismail EA Tulliot-Pelet A Mohsen AM Al-Saleh Q 《Acta paediatrica (Oslo, Norway : 1992)》2006,95(9):1140-1143
Allgrove syndrome (or triple-A syndrome) is a rare autosomal recessive disorder characterized by alacrima, achalasia, adrenal insufficiency (glucocorticoid in the majority of cases) and autonomic/neurological abnormalities. This disease is now known to be caused by mutation in the AAAS gene located on chromosome 12q13. Diagnosis should be readily available when the full-blown features are there, but it becomes less apparent when presentation is atypical or in the evolving process. We present a brother and sister (12 and 19 y old, respectively) born to consanguineous parents of Palestinian origin with Allgrove syndrome. The index patient was erroneously diagnosed to be a case of familial dysautonomia before the diagnosis of adrenal insufficiency was made at the age of 7.5 y, while his elder sister had only alacrima from birth and developed achalasia at the age of 15 y. She started to develop early evidence of adrenal disease at the age of 19 y. Both of them had neuroautonomic dysfunction. The diagnosis of Allgrove syndrome was confirmed in these two patients by studying the gene mutation in the family. The sequencing of the AAAS gene in the two patients identified a novel homozygous mutation within intron 5 (IVS5+1G-->A). Both parents as well as all three other children were heterozygous for the same mutation. CONCLUSION: These two cases illustrate the heterogenous nature and the intrafamilial phenotypic variability of Allgrove syndrome. 相似文献
89.
Soleymani Majd H El Hamamy E Chandrasekar R Ismail L 《Archives of gynecology and obstetrics》2009,279(3):385-386
Patients with complex medical problems should be counselled about the need for highly effective contraception. As failure
resulting in pregnancy, could cause significant morbidity and mortality. The LNG–IUS has gained great popularity and generally
has a low side effect profile; however, perforation of the uterus and migration of the device is a potentially serious complication
known to be associated with its use. The current accepted management is removal of the device from the abdominal cavity in
order to prevent further morbidity. However this is not always a simple matter in patients who have complex medical problems
and who are deemed unfit for surgery. Each time the patient comes for renewal of the contraceptive method, clinicians need
to reassess the risks and benefits. This is particularly relevant in patients who have complex medical problems where special
attention needs to be given, not only to immediate risks but also to long-term ones. Careful individualised counselling and
consideration are paramount and perhaps it would have been prudent to discuss vasectomy with this patient and her husband
(as the first line of contraception), as this may have avoided the ensuing complications arising from the chosen method. 相似文献
90.
Ahmed Mousa Altaf A. Kondkar Saleh A. Al-Obeidan Taif A. Azad Tahira Sultan Essam Osman Khaled K. Abu-Amero 《Saudi medical journal》2015,36(6):671-677