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91.
Demetrius Ellis Ron Shapiro Mark L. Jordan Velma P. Scantlebury Nisan Gilboa Laszlo Hopp Nancy Weichler Andreas G. Tzakis Richard L. Simmons 《Pediatric nephrology (Berlin, Germany)》1994,8(2):193-200
Clinical aspects of FK-506 or cyclosporine immunosuppression regimens were evaluated in 48 consecutive pediatric renal transplant recipients. Tapering and discontinuation of prednisone was employed only in children receiving FK-506 who experienced minor or no rejection episodes during the 1st posttransplant month. At 1 year follow-up, 17 of 22 (77%) of all children with functioning allografts were receiving no prednisone (n=13) or a mean dosage of 0.07 mg/kg per day (n=4). During the 1st month, acute cellular rejection was more common in the FK-506 group (0.58 vs. 0.21 rejections per patient,P<0.05) but allograft survival (92%) and renal function at 1 year posttransplant were identical in both groups. Compared with the cyclosporine regimen, FK-506 immunosuppression may be associated with a higher incidence of cytomegalovirus or reversible Epstein-Barr virus-induced lymphoproliferative disease. However, the FK-506 group had less hirsutism and gingival hypertrophy and required fewer antihypertensive medications independent of steroid use. Height standard deviation scores and weight-for-height index improved only in preadolescents receiving FK-506 but no prednisone (P<0.02 andP<0.05, respectively), but did not differ between children on FK-506 plus prednisone and those in the cyclosporine group. We conclude that the major advantages of FK-506 over cyclosporine immunosuppression are a reduced severity of hypertension and an improved cosmetic appearance which may improve long-term medical compliance. When used as monotherapy, FK-506 also shows promise in relieving the growth retardation associated with cyclosporine regimens that include prednisone. 相似文献
92.
Hans J. Biersack Bernd Briele Andreas L. Hotze Peter Oehr Liu Qian Mohamed A. Mekkawy Wei-Jen Shih 《Annals of nuclear medicine》1992,6(3):131-136
Nuclear Medicine offers screening methods for oncology such as bone and bone marrow scintigraphy. During the last two decades, special procedures have gained widespread application. This paper is centered around the “tumor-specific” radiopharmaceuticals. In patients with thyroid cancer, I-131 still plays a significant role. Ga-67 still has its indications in lymphoma, while in other diseases Tl-201 cloride is now the agent of choice. Especially in thyroid cancer, Tl-201 has proved to be a reliable tumor imaging radiopharmaceutical. More recently, Tc-99m MIBI was introduced for tumor imaging. Tc-99m HMPAO may also be used for tumor scintigraphy, especially in brain lesions. In addition, I-123 IMP has successfully been used for imaging malignant melanoma. Another promising field of tumor diagnosis is receptor imaging. In neuroblastoma and malignant pheochromocytoma, I-131/123 mIBG is the radiopharmaceutical of choice and may be considered as a receptor imaging agent also. First clinical results with In-111 octreotide show potentials as somatostatine-receptor radiopharmaceutical in insulinoma, islet cell carcinoma, medullary and lung cancer, while I-123 estradiol needs some improvement until it may be recommended as diagnostic tool in breast cancer. Since 1978, radiolabeled poly- or monoclonal tumor antibodies and their fragments have gained widespread application. Especially the Tc-99m 225.28S melanoma antibody, I-131 or Tc-99m CEA and In-111/I-131 labeled OC-125 antibodies have proven to be of clinical significance in melanoma, colorectal and ovarian cancer. 相似文献
93.
94.
Two cases are reported in which, after ACL reconstruction with autologous hamstring grafts, tibial polylactide interference
screws migrated into the knee joint. Clinically, both patients presented with recurrent locking of the joint. In one case,
a broken 15 mm-long tip of the screw was found intra-articularly. In the other case, the whole screw had migrated into the
joint cavity. The degradation process of polylactic acid, operative technique and bone quality are discussed as possible reasons
for these complications. 相似文献
95.
Ohne Zusammenfassung 相似文献
96.
Zusammenfassung Hintergrund: Bei Patienten mit stumpfem Thoraxtrauma muss mit einer Contusio cordis gerechnet werden. Das Spektrum der Symptomatik variiert von einer leichten regionalen myokardialen Funktionsstörung bis hin zur Ruptur und zum plötzlichen Herztod. Fallbeschreibung: Ein 27-jähriger Patient wurde nach einem Fußtritt gegen die Brust bei Kammerflimmern reanimiert. Das EKG sowie das Enzymmuster entsprachen denen eines akuten Myokardinfarkts, echokardiographisch zeigte sich eine Hypokinesie apikal und anteroseptal bei mittelgradig reduzierter Pumpfuktion. Die 10 Tage nach dem Trauma durchgeführte Koronarangiographie und Lävokardiographie ergaben einen unauffälligen Befund. Schlussfolgerung: Als Ursache des primären Kammerflimmerns und der initialen elektro- und echokardiographischen Befunde muss aufgrund der Anamnese eine Contusio cordis diskutiert und in der Therapie berücksichtigt werden. Abstract Background: Patients with a blunt chest trauma often sustain myocardial contusion. The spectrum of symptoms varies from regional myocardial dysfunction to myocardial rupture of sudden cardiac death. Case Report: After a kick against his chest, a 27-year-old patient was resuscitated because of ventricular fibrillation. ECG and enzymatic pattern corresponded to an acute myocardial infarction, the echocardiogram revealed an apical and anteroseptal hypokinesia. 10 days after the acute event, coronary arteriography and ventriculography did not show any abnormalities. Conclusion: On the basis of the anamnesis, a myocardial contusion must be discussed as reason for the ventricular fibrillation and the pathologic findings in ECG and echocardiogram. This has to be considered in the therapy. 相似文献
97.
Summary Cerebellar nuclear afferents from some caudal brain stem nuclei in the cat were studied by means of retrograde transport after implantation of the wheat germ agglutinin-horseradish peroxidase complex in crystalline form in the cerebellar nuclei. The findings give evidence that projections to the cerebellar nuclei from certain nuclei of the reticular formation proper (e.g., from the gigantocellular reticular nucleus) are very modest, while there appears to be no or extremely few cerebellar nuclear afferents from the paramedian reticular, spinal trigeminal, gracile, cuneate and external cuneate nuclei. Previous tracer studies have given evidence that also the pontine and red nuclei send very few, if any, fibres to the cerebellar nuclei. All these brain stem regions are known to project to the cerebellar cortex. This relative lack of mossy fibre collaterals to the cerebellar nuclei is discussed with references to previous literature on the distribution of cerebellar nuclear afferents, and the problem of how the cerebellar nuclei are facilitated is considered.Abbreviations
Br.c.
superior cerebellar peduncle (brachium conjunctivum)
-
Br.p.
middle cerebellar peduncle (brachium pontis)
-
C.r.
interior cerebellar peduncle (restiform body)
-
HRP
horseradish peroxidase
-
L
left
-
N.c.
cuneate nucleus
-
N.c.e.
external cuneate nucleus
-
N.c.t.
nucleus of corpus trapezoideum
-
NIA
anterior interposed nucleus
-
NIP
posterior interposed nucleus
-
NL
lateral (dentate) nucleus
-
N.l.l.
nuclei of lateral lemniscus
-
NM
medial (fastigial) nucleus
-
N.m.X.
dorsal motor vagal nucleus
-
N.mes.
mesencephalic trigeminal nucleus
-
N.r.l.
lateral reticular nucleus (nucleus of the lateral funiculus)
-
N.r.p.
paramedian reticular nucleus
-
N.r.t.
reticular tegmental pontine nucleus
-
N V, VI, VII, XII
root fibres of cranial nerves
-
Ol.s.
superior olive
-
P.h.
nucleus praepositus hypoglossi
-
Py
pyramid
-
R
right
-
R.gc.
gigantocellular reticular nucleus
-
R.l.
lateral reticular nucleus of Meessen and Olszewski
-
R.p.c.
caudal pontine reticular nucleus
-
R.pc.
parvicellular reticular nucleus
-
R.v.
ventral reticular nucleus
-
Tr.sp.V.
spinal tract of the trigeminal nerve
-
T.s.
solitary tract surrounded by nucleus of solitary tract
-
V.m.
medial vestibular nucleus
-
WGA
wheat germ agglutinin
-
WGA-HRP
wheat germ agglutinin-horseradish peroxidase conjugate
-
V, VI, VII, X, XII
motor nuclei of cranial nerves 相似文献
98.
Karl Lehner M.D. Maximilian Reiser Ulrich Gebhardt Andreas Heuck Jürgen Schaff 《Cardiovascular and interventional radiology》1987,10(2):71-74
In contrast to conventional film angiography, the perfusion pattern of hepatic arterial chemotherapy was consistently visualized
by DSA in 40 patients with implanted Infusaid pump or Port-A devices. Incomplete perfusion of a liver region by the cytotoxic
agent was recognized by DSA as accurately as by nuclide scintigraphy. Furthermore, DSA appeared to be more sensitive in determining
aberrantly perfused extrahepatic regions; this was especially true when there was a nonligated right hepatic artery. Specific
details of vascular lesions and associated complicating events also could be satisfactorily analyzed by DSA only. 相似文献
99.
Transfer of the HIV-1 cyclophilin-binding site to simian immunodeficiency virus from Macaca mulatta can confer both cyclosporin sensitivity and cyclosporin dependence 总被引:5,自引:0,他引:5
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Anatoly A. Bukovsky Andreas Weimann Molly A. Accola Heinrich G. Gttlinger 《Proceedings of the National Academy of Sciences of the United States of America》1997,94(20):10943-10948
HIV-1 specifically incorporates the peptidyl prolyl isomerase cyclophilin A (CyPA), the cytosolic receptor for the immunosuppressant cyclosporin A (CsA). HIV-1 replication is inhibited by CsA as well as by nonimmunosuppressive CsA analogues that bind to CyPA and interfere with its virion association. In contrast, the related simian immunodeficiency virus SIVmac, which does not interact with CyPA, is resistant to these compounds. The incorporation of CyPA into HIV-1 virions is mediated by a specific interaction between the active site of the enzyme and the capsid (CA) domain of the HIV-1 Gag polyprotein. We report here that the transfer of HIV-1 CA residues 86–93, which form part of an exposed loop, to the corresponding position in SIVmac resulted in the efficient incorporation of CyPA and conferred an HIV-1-like sensitivity to a nonimmunosuppressive cyclosporin. HIV-1 CA residues 86–90 were also sufficient to transfer the ability to efficiently incorporate CyPA, provided that the length of the CyPA-binding loop was preserved. However, the resulting SIVmac mutant required the presence of cyclosporin for efficient virus replication. The results indicate that the presence or absence of a type II tight turn adjacent to the primary CyPA-binding site determines whether CyPA incorporation enhances or inhibits viral replication. By demonstrating that CyPA-binding-site residues can induce cyclosporin sensitivity in a heterologous context, this study provides direct in vivo evidence that the exposed loop between helices IV and V of HIV-1 CA not merely constitutes a docking site for CyPA but is a functional target of this cellular protein. 相似文献
100.
Can we predict the outcome of a partial rupture of the anterior cruciate ligament?
A prospective study of 43 cases 总被引:2,自引:0,他引:2
D. Fritschy Andreas Panoussopoulos Richard Wallensten Robin Peter 《Knee surgery, sports traumatology, arthroscopy》1997,5(1):2-5
The concept of partial rupture of the anterior cruciate ligament (ACL) has been confirmed by arthroscopic examination and
palpation. We present a prospective study of 43 patients who were diagnosed arthroscopically as suffering from a partial rupture
of the ACL by the same surgeon. The patients followed a rehabilitation protocol and were examined by an independant observer
after 5 years. Twenty-five patients had a stable knee, whereas 18 eventually suffered a complete ACL rupture. ACL partial
rupture is easily recognizable with arthroscopy, but the quantity and state of the still intact fibres is difficult to assess.
Received: 20 April 1996 Accepted: 17 December 1996 相似文献