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41.
42.
Scheil-Bertram S Hartwig E Brüderlein S Melzner I von Baer A Roessner A Möller P Schulte M 《Virchows Archiv : an international journal of pathology》2004,444(3):293-299
In 1942, Jaffe and Lichtenstein introduced the term aneurysmal bone cyst (ABC). Primary ABC is characterized by the presence of spongy or multi-cameral cystic tissue filled with blood. The process is benign, but it is locally destructive and has a high propensity for recurrence. In this paper, we present the third case of multiple metachronous primary ABCs as a rare variant of ABC. We describe the 10-year history of a 12-year-old boy with metachronous multiple primary ABCs at five different sites (right proximal humerus, right ulna, bilateral distal radius and right lateral clavicle). Furthermore, our patient suffered from vascular malformations, such as aortic isthmus stenosis, hypoplastic thoraco-abdominal aorta and bilateral renal artery stenosis. To date, in contrast to solitary ABC, the multiple lesions have been found more frequently in male individuals. Using interphase cytogenetics, we analyzed three of five of the patients ABCs and one of these was also analyzed by GTG-banding. No chromosomal abnormalities were found. Significantly, we excluded the missense mutation of codon 201 in guanine nucleotide-binding protein 1 gene consistently found in McCune-Albright syndrome (MAS) and in non-MAS cases of polyostotic fibrous dysplasia of bone with or without secondary ABC. 相似文献
43.
Volker Hofmann Helmut Ringsdorf Erich Schaumlffel 《Macromolecular chemistry and physics.》1980,181(2):351-366
Poly[2-(methylsulfinyl)ethyl acrylate] ( 1 ) was synthesized as well as derivatives 14C-labelled in side groups ( 6 ) or 14C-labelled in the main chain ( 11 ). Polymer 11 with the 14C-labelled main chain was fractionated by precipitation. The η-M-relation determined by measurements of unlabelled polymers in the ultracentrifuge for comparison was used to establish the viscosimetrically determined molecular weights of the labelled fractions. After intravenous application of aqueous solutions of the polymer in rats the excretion rate up to 72 h after treatment was ascertained to ca. 50%; the concentration in the blood serum was found to be strikingly high. A tendency to reinforced storage in organs of high phagocytose activity by growing molecular weight was observed. The tumor affinity was — if at all — low. 相似文献
44.
The gene for a cell surface glycoprotein recognized by a mouse monoclonal antibody (Mab 4), has been assigned to human chromosome 11 by the study of mouse-human lymphocyte hybrids. The antigen is present on all human peripheral blood leukocytes, on human fibroblasts, and on human lymphoid and erythroid cell lines, but not on erythrocytes. Immunoprecipitation and polyacrylamide slab gel electrophoresis of both human cells and mouse-human hybrid clones carrying human chromosome 11 show that the apparent molecular weight of this glycoprotein is 75,000. 相似文献
45.
46.
Summary By means of electron microscopy a study has been made of different developmental stages of Eimeria callospermophili, E. falciformis, Toxoplasma gondii, Frenkelia spec. (= M-organism), Babesia bigemina, and B. ovis. Major emphasis was given to the analysis of some characteristic organelles of the motile stages of the sporozoans. These organelles were the paired organelle, the micronemes and the micropores.Supported by the Deutsche Forschungsgemeinschaft. 相似文献
47.
Summary Light and electron microscope studies on the Sarcocystis of Rattus fuscipes showed that sarcocysts of two types occurred in this rat. These types could be distinguished from each other on the morphology of their cyst walls, on the size and micromorphology of their zoites, as well as by the changes they induced in the host cell. On the basis of these differences, it was concluded that the two sarcocyst types belonged to distinct Sarcocystis species. The possible life histories of the infections occurring in the rats were considered.Abbreviations A
Amylopectin
- C
Conoid
- CF
Connected Tissue Fibres
- CP
Capillary
- CW
Cyst Wall
- DC
Daughter Cell
- DCA
Daughter Cell Anlagen
- E
Erythrocyte
- FE
Fibrillar Elements
- GA
Golgi Adjunct
- GO
Golgi Apparatus
- GS
Ground Substance
- HC
Host Cell
- HCN
Host Cell Nucleus
- I
Invagination
- M
Metrocyte
- ME
Merozoite
- MI
Mitochondrion
- MIH
Host Cell Mitochondrion
- MN
Micronemes
- N
Nucleus
- NE
Nucleus of Endothelial Cell
- NR
Neck Region
- NU
Nucleolus
- OG
Osmiophilic Granules
- P
Papilla
- PI
Pellicular Invagination
- PR
Projections
- PW
Primary Wall
- RH
Rhoptries
- S
Septum
- SP
Sarcoplasm
- TS
Thread-like Structures
- Z
Zoites
Visiting DAAD Research Fellow from the Department of Parasitology, University of Queensland, AustraliaSupported by the Deutsche Forschungsgemeinschaft 相似文献
48.
W. Schröter E. Schulz R. Bonn 《Journal of molecular medicine (Berlin, Germany)》1970,48(16):1013-1014
Zusammenfassung Bei 16 von 17 Patienten mit Osteomyelofibrose wurden in den Erythrocyten erhöhte Konzentrationen an reduziertem Glutathion nachgewiesen. Die Bestimmung des Glutathions kann als differentialdiagnostisch wertvolles Kriterium für die Charakterisierung der Osteomyelofibrose angesehen werden.
Mit Unterstützung durch die Deutsche Forschungsgemeinschaft. 相似文献
Summary In 16 of 17 patients with osteomyelofibrosis the concentration of erythrocyte reduced glutathione was increased. It is concluded that the determination of erythrocyte glutathione is of differential diagnostic value in the characterization of osteomyelofibrosis.
Mit Unterstützung durch die Deutsche Forschungsgemeinschaft. 相似文献
49.
An IFN-beta-albumin fusion protein that displays improved pharmacokinetic and pharmacodynamic properties in nonhuman primates. 总被引:6,自引:0,他引:6
Cynthia Sung Bernardetta Nardelli David W LaFleur Erich Blatter Marta Corcoran Henrik S Olsen Charles E Birse Oxana K Pickeral Junli Zhang Devanshi Shah Gordon Moody Solange Gentz Lisa Beebe Paul A Moore 《Journal of interferon & cytokine research》2003,23(1):25-36
The long half-life and stability of human serum albumin (HSA) make it an attractive candidate for fusion to short-lived therapeutic proteins. Albuferon (Human Genome Sciences [HGS], Inc., Rockville, MD) beta is a novel recombinant protein derived from a gene fusion of interferon-beta (IFN-beta ) and HSA. In vitro, Albuferon beta displays antiviral and antiproliferative activities and triggers the IFN-stimulated response element (ISRE) signal transduction pathway. Array analysis of 5694 independent genes in Daudi-treated cells revealed that Albuferon beta and IFN-beta induce the expression of an identical set of 30 genes, including 9 previously not identified. In rhesus monkeys administered a dose of 50 microg/kg intravenously (i.v.) or subcutaneously (s.c.) or 300 microg/kg s.c., Albuferon beta demonstrated favorable pharmacokinetic properties. Subcutaneous bioavailability was 87%, plasma clearance at 4.7-5.7 ml/h/kg was approximately 140-fold lower than that of IFN-beta, and the terminal half-life was 36-40 h compared with 8 h for IFN-beta. Importantly, Albuferon beta induced sustained increases in serum neopterin levels and 2',5' mRNA expression. At a molar dose equivalent to one-half the dose of IFN-beta, Albuferon beta elicited comparable neopterin responses and significantly higher 2',5'-OAS mRNA levels in rhesus monkeys. The enhanced in vivo pharmacologic properties of IFN-beta when fused to serum albumin suggest a clinical opportunity for improved IFN-beta therapy. 相似文献
50.
Erich Kutzer 《Parasitology research》1964,24(6):561-577
Zusammenfassung Es wird vorgeschlagen, die Gattung Knemidocoptes
Fürstenberg, 1870, auf Grund zahlreicher charakteristischer Merkmale als eigene Familie in der Überfamilie Sarcoptoidea Dubinin, 1951, zu führen. Die Familie Knemidocoptidae besitzt nur eine Gattung mit 9 verschiedenen Arten: K. glaberrimus, K. philomelae, K. fossor, K. mutans, K. jamaicensis, K. pilae, K. laevis, K. gallinae, K. prolificus. Von jeder Species wird eine ausführliche Darstellung gegeben und soweit bekannt ihre Biologie und Pathogenität besprochen. Das bisher noch nicht beobachtete Männchen von K. jamaicensis wird beschrieben. Ein Bestimmungsschlüssel der Gattung Knemidocoptes wird angeführt.Mit 20 Textabbildungen 相似文献