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Sabrina da Silva Saraiva Fernanda Andrade Orsi Marcos Pereira Santos Tania Machado Silmara Montalvão Carolina Costa-Lima Erich Vinícius de Paula Marina Pereira Colella Joyce Annichino-Bizzacchi 《Journal of thrombosis and thrombolysis》2016,42(1):146-153
The home prothrombin time/international normalized ratio (PT/INR) self-management could be convenient for patients, enhancing treatment compliance and improving the quality of the oral anticoagulation. However, patient self-management (PSM) of oral anticoagulation may not be feasible for up to half of the patients due to cognitive or educational issues. In the present study, we aimed to evaluate the feasibility of a PSM program in a public health medical center that provides care for low-income patients. We also aimed to determine the accuracy of individual point-of-care devices (CoaguChek XS®) during long-term of home manipulation. Patients’ time-in-therapeutic range (TTR) and perception of quality of life, were evaluated at scheduled study-visits to the center. Additionally, the accuracy of individual CoaguChek XS® was evaluated in comparison to the standard automated coagulometer at scheduled study-visits to the center. Twenty-five patients were included in the PSM program. The median TTR of patients was 75 % before inclusion, 72 % at 3 months, 75 % at 6 months and 100 % at 12 months after the beginning of self-management (P = 0.14).The median DASS scores were 64, 63, 61.5 and 71.5 before inclusion and at 3, 6 and 12 months, respectively (P = 0.09). One hundred paired INR values were obtained. Correlation between INR values delivered by individual CoaguChek XS® and the automated coagulometer was 94 % and the mean result bias was 0.07 INR units. The coefficient of correlation and the mean bias between methods was stable during 24 months of follow-up. The present study suggests that PSM is feasible for patients treated in the public health system and that the results delivered by CoaguChek XS® have long-term reliability. 相似文献
165.
Julia Ebert Jan Peter Sperhake Olaf Degen Ann Sophie Schröder 《Forensic science, medicine, and pathology》2018,14(3):332-341
In Hamburg, Germany, the initiation of HIV post-exposure prophylaxis (HIV PEP) in cases of sexual violence is often carried out by forensic medical specialists (FMS) using the city’s unique Hamburg Model. FMS-provided three-day HIV PEP starter packs include a combination of raltegravir and emtricitabine/tenofovir. This study aimed to investigate the practice of offering HIV PEP, reasons for discontinuing treatment, patient compliance, and whether or not potential perpetrators were tested for HIV. We conducted a retrospective study of forensic clinical examinations carried out by the Hamburg Department of Legal Medicine following incidents of sexual violence from 2009 to 2016. One thousand two hundred eighteen incidents of sexual violence were reviewed. In 18% of these cases, HIV PEP was initially prescribed by the FMS. HIV PEP indication depended on the examination occurring within 24 h after the incident, no/unknown condom use, the occurrence of ejaculation, the presence of any injury, and the perpetrator being from population at high risk for HIV. Half of the HIV PEP recipients returned for a reevaluation of the HIV PEP indication by an infectious disease specialist, and just 16% completed the full month of treatment. Only 131 potential perpetrators were tested for HIV, with one found to be HIV positive. No HIV seroconversion was registered among the study sample. Provision of HIV PEP by an FMS after sexual assault ensures appropriate and prompt care for victims. However, patient compliance and completion rates are low. HIV testing of perpetrators must be carried out much more rigorously. 相似文献
166.
IL‐33 polymorphisms are associated with increased risk of hay fever and reduced regulatory T cells in a birth cohort
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Paul C. Schröder Vera I. Casaca Sabina Illi Maximilian Schieck Sven Michel Andreas Böck Caroline Roduit Remo Frei Anna Lluis Jon Genuneit Petra Pfefferle Marjut Roponen Juliane Weber Charlotte Braun‐Fahrländer Josef Riedler Roger Lauener Dominique Angèle Vuitton Jean‐Charles Dalphin Juha Pekkanen Erika von Mutius Michael Kabesch Bianca Schaub PASTURE Study group 《Pediatric allergy and immunology》2016,27(7):687-695
167.
Aggregation‐induced changes in the chemical exchange saturation transfer (CEST) signals of proteins
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Steffen Goerke Katharina S. Milde Raul Bukowiecki Patrick Kunz Karel D. Klika Thomas Wiglenda Axel Mogk Erich E. Wanker Bernd Bukau Mark E. Ladd Peter Bachert Moritz Zaiss 《NMR in biomedicine》2017,30(1)
Chemical exchange saturation transfer (CEST) is an MRI technique that allows mapping of biomolecules (small metabolites, proteins) with nearly the sensitivity of conventional water proton MRI. In living organisms, several tissue‐specific CEST effects have been observed and successfully applied to diagnostic imaging. In these studies, particularly the signals of proteins showed a distinct correlation with pathological changes. However, as CEST effects depend on various properties that determine and affect the chemical exchange processes, the origins of the observed signal changes remain to be understood. In this study, protein aggregation was identified as an additional process that is encoded in the CEST signals of proteins. Investigation of distinct proteins that are involved in pathological disorders, namely amyloid beta and huntingtin, revealed a significant decrease of all protein CEST signals upon controlled aggregation. This finding is of particular interest with regard to diagnostic imaging of patients with neurodegenerative diseases that involve amyloidogenesis, such as Alzheimer's or Huntington's disease. To investigate whether the observed CEST signal decrease also occurs in heterogeneous mixtures of aggregated cellular proteins, and thus prospectively in tissue, heat‐shocked yeast cell lysates were employed. Additionally, investigation of different cell compartments verified the assignment of the protein CEST signals to the soluble part of the proteome. The results of in vitro experiments demonstrate that aggregation affects the CEST signals of proteins. This observation can enable hypotheses for CEST imaging as a non‐invasive diagnostic tool for monitoring pathological alterations of the proteome in vivo. 相似文献
168.
Alberto Addis Maxime Gaasch Alois J Schiefecker Mario Kofler Bogdan Ianosi Verena Rass Anna Lindner Gregor Broessner Ronny Beer Bettina Pfausler Claudius Thom Erich Schmutzhard Raimund Helbok 《Journal of cerebral blood flow and metabolism》2021,41(2):359
Elevated body temperature (Tcore) is associated with poor outcome after subarachnoid hemorrhage (SAH). Brain temperature (Tbrain) is usually higher than Tcore. However, the implication of this difference (Tdelta) remains unclear. We aimed to study factors associated with higher Tdelta and its association with outcome. We included 46 SAH patients undergoing multimodal neuromonitoring, for a total of 7879 h of averaged data of Tcore, Tbrain, cerebral blood flow, cerebral perfusion pressure, intracranial pressure and cerebral metabolism (CMD). Three-months good functional outcome was defined as modified Rankin Scale ≤2. Tbrain was tightly correlated with Tcore (r = 0.948, p < 0.01), and was higher in 73.7% of neuromonitoring time (Tdelta +0.18°C, IQR −0.01 – 0.37°C). A higher Tdelta was associated with better metabolic state, indicated by lower CMD-glutamate (p = 0.003) and CMD-lactate (p < 0.001), and lower risk of mitochondrial dysfunction (MD) (OR = 0.2, p < 0.001). During MD, Tdelta was significantly lower (0°C, IQR −0.2 – 0.1; p < 0.001). A higher Tdelta was associated with improved outcome (OR = 7.7, p = 0.002). Our study suggests that Tbrain is associated with brain metabolic activity and exceeds Tcore when mitochondrial function is preserved. Further studies are needed to understand how Tdelta may serve as a surrogate marker for brain function and predict clinical course and outcome after SAH. 相似文献
169.
Microwave-assisted hydrothermal treatment of Lemna minor plant material was studied under subcritical conditions. The water phases of this process were extracted with polar and nonpolar solvents and the extracts were investigated by GC/MS screening analyses for value added products. The polar extracts were dominated by compounds known as flavouring agents and partly as platform chemicals, e.g. hydroxyacetone, 1-hydroxybutan-2-one, furfural, cyclotene and pyrrolidone. Pyridinol, an important educt for heterocyclic chemistry, was another interesting product. Benzaldehyde and oleamide were detected as main products in nonpolar n-hexane extracts. An essential aspect is that a large proportion of compounds like aldehyds and ketones were obtained when mild hydrothermal processing was applied. 相似文献