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排序方式: 共有1784条查询结果,搜索用时 31 毫秒
71.
Ueno H Yamada Y Watanabe R Mukai E Hosokawa M Takahashi A Hamasaki A Fujiwara H Toyokuni S Yamaguchi M Takeda J Seino Y 《Pancreas》2005,31(2):126-131
The neural precursor cell-specific marker nestin is expressed in fetal and adult pancreas, but its role is not fully understood. Using nestin-enhanced green fluorescent protein (EGFP) transgenic mice and fluorescence activated cell sorter, we characterized nestin-positive cells in adult mice pancreas. EGFP mRNA- and protein-positive cells expressed amylase, a pancreatic exocrine marker. Interestingly, EGFP mRNA-negative and protein-positive cells expressed insulin, glucagon, somatostatin and pancreatic polypeptide, pancreatic endocrine markers. These findings demonstrate that nestin-positive cells comprise a portion of pancreatic exocrine cells and suggest that they can be differentiated into pancreatic endocrine cells. 相似文献
72.
Excessive daytime sleepiness (EDS) is a common but underrecognized and preventable cause of traffic accidents. It creates a problem of particular importance for professional drivers. We performed the Epworth Sleepiness Scale (ESS) and questionnaire related to their history of traffic accidents to 118 professional taxi drivers to determine the EDS and its effects on driving performance in taxi drivers. There were 58 (49.2%) subjects with loud snoring, 8 (5.9%) subjects with cardinal symptoms due to obstructive sleep apnea syndrome (OSAS) and 28 (23.7%) subjects with ESS > or =10 in the group of taxi drivers. Eighty (67.8%) drivers had been involved in a traffic accident. We found a significant relation between the number of traffic accident and EDS, witnessed apnea, cardinal symptom related to OSAS but not with snoring. The present data that sleepiness is a common symptom in taxi drivers and may be related to traffic accident. 相似文献
73.
Eri Hagiwara Takuma Katano Kohsuke Isomoto Ryota Otoshi Hideaki Yamakawa Ryo Okuda Akimasa Sekine Tomohisa Baba Shigeru Komatsu Takashi Ogura 《Respiratory investigation》2019,57(1):54-59
Background
The incidence of asymptomatic pulmonary Mycobacterium avium complex (MAC) disease appears to be increasing. This study aimed to determine the clinical characteristics and examine early outcomes of patients newly diagnosed with MAC disease.Methods
We retrospectively reviewed the medical records of all 184 patients newly diagnosed with MAC disease between April 2013 and March 2015 at our hospital. Culture conversion, defined as at least two consecutive negative cultures, was used as the early outcome measure.Results
Of 184 patients, 45 were male and 139 were female, with a mean age of 70 years. Abnormal chest shadow found during an annual health check-up (58 patients) or incidentally during visits for other diseases (72 patients), was the major reason for referral to hospital, typically with no symptoms. Anti-MAC IgA antibody was positive in 64.5% of patients, and the positive rate was associated with the extent of lesions. Clarithromycin-based multi-drug chemotherapy was initiated in 111 patients. Culture conversion was achieved in 61 of 82 (74.4%) patients who were able to continue multi-drug chemotherapy. Patients who achieved culture conversion were more likely to be younger, female, and have a lower smear grade and nodular-bronchiectatic type. Multivariate logistic regression analysis identified patient age and smear grade as predictive variables.Conclusions
Abnormal chest shadow found during health check-up was the major reason for hospital visits, and most were asymptomatic. Culture conversion was achieved in three-fourths of patients treated, and was associated with age and smear grade, supporting early intervention at a younger age. 相似文献74.
75.
Eri Hara Motoki Ueda Akira Makino Isao Hara Eiichi Ozeki Shunsaku Kimura 《ACS medicinal chemistry letters》2014,5(8):873-877
l-lactic acid)30 (AB-type), which accumulates in solid
tumors through the enhanced permeability and retention (EPR) effect.
However, lactosome on multiple administrations changed its pharmacokinetics
from accumulation in tumors to liver due to the production of antilactosome
IgM, which was triggered by the first administration. This phenomenon
is called the accelerated blood clearance (ABC). In order to reduce
the production of antilactosome IgM, a novel nanoparticle composed
of (poly(sarcosine)23)3-block-poly(l-lactic acid)30 (A3B-type)
was prepared. The A3B-type lactosome at the second administration
showed an in vivo disposition similar to that at
the first administration due to suppression of antibody production.
This study involving the AB- and A3B-type lactosomes, with
variation of conditions, revealed that the high local density of poly(sarcosine)
chains of the A3B-type lactosome should relate to the prevention
of a polymeric micelle from interacting B-cell receptors. 相似文献
76.
77.
Eri Imagawa Tsuyoshi Konuma Emalyn E. Cork George A. Diaz Kimihiko Oishi 《Clinical genetics》2020,98(6):606-612
RBM10, is an RNA binding protein that is important for development by regulating the expression of multiple genes. RBM10 is on the X chromosome, and nonsense and frameshift RBM10 variants cause TARP syndrome in males. In a 4-year-old male, we identified a novel maternally inherited missense RBM10 variant in the RRM2 RNA binding domain, c.965C>T, p.Pro322Leu. His clinical features included intellectual disability, developmental delay, growth restriction, hypotonia, and craniofacial malformations. These features were much milder than those described in previously reported cases of TARP syndrome. By in vitro assays, we found that the mutant p.Pro322Leu RBM10 protein retained its specific RNA binding capacity, while gaining a low-affinity nonspecific RNA binding. It was normally localized to the nucleus, but its expression level was significantly reduced with a significantly short half-life. These results indicated that the p.Pro322Leu missense variant causes a developmental disorder in humans through a unique loss-of-function mechanism. 相似文献
78.
79.
Ayako Sakakibara Kei Kohno Eri Ishikawa Yuka Suzuki Yuta Tsuyuki Satoko Shimada Kazuyuki Shimada Akira Satou Taishi Takahara Akiko Ohashi Emiko Takahashi Seiichi Kato Shigeo Nakamura Naoko Asano 《Journal of Clinical and Experimental Hematopathology》2021,61(4):182
The programmed cell death 1 (PD1)/PD1 ligand (PD-L1) axis plays an important role in tumor cell escape from immune control and has been most extensively investigated for therapeutic purposes. However, PD-L1 immunohistochemistry is still not used widely for diagnosis. We review the diagnostic utility of PD-L1 (by clone SP142) immunohistochemistry in large-cell lymphomas, mainly consisting of classic Hodgkin lymphoma (CHL) and diffuse large B-cell lymphoma (DLBCL). Neoplastic PD-L1 (nPD-L1) expression on Hodgkin and Reed-Sternberg cells is well-established among prototypic CHL. Of note, EBV+ CHL often poses a challenge for differential diagnosis from peripheral T-cell lymphoma with EBV+ non-malignant large B-cells; their distinction is based on the lack of PD-L1 expression on large B-cells in the latter. The nPD-L1 expression further provides a good diagnostic consensus for CHL with primary extranodal disease conceivably characterized by a combined pathogenesis of immune escape of tumor cells and immunodeficiency. Compared with CHL, the nPD-L1 expression rate is much lower in DLBCL, highlighting some specific subgroups of intravascular large B-cell lymphoma, primary mediastinal large B-cell lymphoma, and EBV+ DLBCL. They consist of nPD-L1-positive and -negative subgroups, but their clinicopathological significance remains to be elucidated. Microenvironmental PD-L1 positivity on immune cells may be associated with a favorable prognosis in extranodal DLBCL. PD-L1 (by SP142) immunohistochemistry has helped us to understand the immune biology of lymphoid neoplasms possibly related by immune escape and/or immunodeficiency. However, knowledge of these issues remains limited and should be clarified for diagnostic consensus in the future. 相似文献
80.
Kenya Ie Tsubasa Sakai Eri Kurosu Iori Motohashi Kunihiro Yagihashi Chiaki Okuse Takahide Matsuda 《Internal medicine (Tokyo, Japan)》2022,61(3):357
We herein report a case of large-vessel vasculitis in a 57-year-old woman who developed an intermittent fever and weight loss. While contrast-enhanced computed tomography was noncontributory, positron emission tomography-computed tomography (PET-CT) revealed the diffuse, intense uptake of fluorodeoxyglucose (FDG) in the aorta and its branches. Although she had no signs of relapse after successful oral corticosteroid therapy, PET-CT at 30 months revealed a persistent FDG uptake in the large vessels, which warranted regular follow-up imaging for vascular complications. In cases with an intense FDG uptake at the diagnosis, PET-CT follow-up after clinical remission may help predict the risk of relapse and vascular complications. 相似文献