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91.
Medeiros R Catunda Ide S Queiroz IV de Morais HH Leao JC Gueiros LA 《General dentistry》2012,60(4):316-321
Soft tissue infections are characterized by acute inflammation, diffuse edema, and suppuration, and are often associated with symptoms such as malaise, fever, tachycardia, and chills. Necrotizing fasciitis is a destructive bacterial infection affecting subcutaneous tissue and superficial fascia and is associated with high rates of mortality. It usually involves the abdomen and extremities, but it also can occur in the head and neck. Early diagnosis is critical and the most commonly accepted treatment includes radical surgical intervention and administration of broad-spectrum antibiotics. This article reports and discusses the case of a patient with odontogenic cervicofacial necrotizing fasciitis, and emphasizes the importance of early and effective treatment. 相似文献
92.
Catunda IS de Medeiros MF Santos LA Melo AR 《International journal of oral and maxillofacial surgery》2012,41(3):344-349
By definition, degloving is skin and subcutaneous tissue detachment, most often affecting the limbs and extremities and occasionally the scalp. Degloving generally stems from high-energy trauma, but can also be intentional, such as in the case of planned surgical access in the anterior region of the mandible in oral-maxillofacial surgery. This paper describes an extreme case of complete traumatic maxillofacial degloving that caused partial avulsion of the soft tissues and maxilla. This is an extremely rare condition that has not previously been described in the literature, as the patient survived despite the risk of imminent death. This case report addresses the decisions made regarding the prevention of necrosis and infection that guided the emergency care and subsequent elective steps. 相似文献
93.
Nícolas de Castro Campos Pinto Mariana de Souza Ferreira Maciel Nathalia dos Santos Rezende Ana Paula do Nascimento Duque Renata de Freitas Mendes Jucélia Barbosa da Silva Monique de Rezende Evangelista Luana Cahon Monteiro Josiane Mello da Silva Juliana de Carvalho da Costa Elita Scio 《The Journal of pharmacy and pharmacology》2020,72(12):1933-1945
94.
Soraia Micaela Silva Fernanda Ishida Corrêa Christina Danielli Coelho de Morais Faria Gabriela Santos Pereira Edna Alves dos Anjos Attié João Carlos Ferrari Corrêa 《Disability and rehabilitation》2016,38(24):2413-2418
Purpose: To evaluate the reproducibility of the Stroke Specific Quality of Life (SS-QOL) items that address the participation component of the International Classification of Functioning, Disability and Health (ICF) and analyse the correlation between the subscore of these 26 items and the total SS-QOL score.Methods: Seventy-five stroke survivors participated in this study. Reproducibility was evaluated using the intraclass correlation coefficient (ICC2,1), standard error of measurement (SEM), minimum detectable change (MDC) and the Bland–Altman plot. The correlation between the subscore of the 26 items and the total SS-QOL score was analysed using Spearman’s correlation coefficients (rho) and simple linear regression. An alpha risk?≤?0.05 was considered for all analyses.Results: The SS-QOL items that address the participation component of the ICF demonstrated excellent reliability (intra-rater ICC2,1?=?0.96; inter-rater ICC2,1?=?0.95). The SEM and MDC were adequate. The Bland–Altman plot demonstrated satisfactory agreement. A significant and strong correlation (rho?=?0.83) was found between the 26 SS-QOL items that address participation and the total SS-QOL score. Moreover, the evaluation of participation was found to explain 73% of the evaluation of health-related quality of life.Conclusion: The 26 SS-QOL items that address the participation component of the ICF demonstrated adequate reproducibility. Thus, participation, which represents the social aspects of functionality, can be adequately evaluated with these items.
- Implications for Rehabilitation
The 26 Stroke Specific Quality of Life items that address participation proved to be reproducible for the analysis of social participation following a stroke.
The findings can lead to a better understanding of the social participation of individuals with chronic hemiparesis and assist in the establishment of adequate treatment for such individuals.
The rehabilitation process can be directed towards more specific goals focused on the patient expectations, thereby contributing to greater humanization and effectiveness of treatment to improve social participation following a stroke.
95.
Prevalence of human herpesvirus 8 infection in people living with HIV/AIDS in Pernambuco,Brazil
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96.
Robert J Ellis David M Small David A Vesey David W Johnson Ross Francis Luis Vitetta Glenda C Gobe Christudas Morais 《Nephrology (Carlton, Vic.)》2016,21(3):170-177
In the last decade, chronic kidney disease (CKD), defined as reduced renal function (glomerular filtration rate (GFR) < 60 mL/min per 1.73 m2) and/or evidence of kidney damage (typically manifested as albuminuria) for at least 3 months, has become one of the fastest‐growing public health concerns worldwide. CKD is characterized by reduced clearance and increased serum accumulation of metabolic waste products (uremic retention solutes). At least 152 uremic retention solutes have been reported. This review focuses on indoxyl sulphate (IS), a protein‐bound, tryptophan‐derived metabolite that is generated by intestinal micro‐organisms (microbiota). Animal studies have demonstrated an association between IS accumulation and increased fibrosis, and oxidative stress. This has been mirrored by in vitro studies, many of which report cytotoxic effects in kidney proximal tubular cells following IS exposure. Clinical studies have associated IS accumulation with deleterious effects, such as kidney functional decline and adverse cardiovascular events, although causality has not been conclusively established. The aims of this review are to: (i) establish factors associated with increased serum accumulation of IS; (ii) report effects of IS accumulation in clinical studies; (iii) critique the reported effects of IS in the kidney, when administered both in vivo and in vitro; and (iv) summarize both established and hypothetical therapeutic options for reducing serum IS or antagonizing its reported downstream effects in the kidney. 相似文献
97.
da Silveira EB Cordeiro BA Ribeiro BM de Castro ME Soares EF Báo SN 《Virus research》2007,130(1-2):182-192
An Anticarsia gemmatalis multiple nucleopolyhedrovirus (AgMNPV) mutant, vApAg, induces apoptosis in a cell culture derived from Anticarsia gemmatalis (UFL-AG-286), reducing viral progeny. We have investigated apoptosis induction in vivo by vApAg in A. gemmatalis larvae and its correlation to infectivity reduction. LC50, LD50, LT50 and the mean time to death of larvae were determined for vApAg and AgMNPV. Apoptosis was accessed for hemocytes of infected larvae using light and transmission electron microscopy. All types of hemocytes can be infected by vApAg. After 12 h post-infection (h p.i.), typical cellular modifications associated to nucleopolyhedrovirus infection were observed. Apoptosis becomes evident after 24 h p.i., and massive after 72 h p.i. Necrosis of infected cells was also observed. Despite cell death, hemocytes produced budded viruses and polyhedra. Pl and gh1-type hemocytes presented phagocytic activity. Agarose gel electrophoresis revealed fragmentation of hemocytes DNA at late times post-infection. The LC50 and LD50 were between five- and six-fold higher for vApAg. The LT50 and the mean time to death were higher for vApAg in a same treatment or for a similar mortality induced by AgMNPV. These results show correlation of apoptosis and the reduced infectivity of vApAg in A. gemmatalis larvae. 相似文献
98.
Rafael Lopes Oliveira Danilo Jorge Custódio Claudia Ramos de Rainho Erika Morais Israel Felzenszwalb Sérgio Machado Corrêa Débora Almeida Azevedo Graciela Arbilla 《Air quality, atmosphere, & health》2018,11(5):581-590
In this study, the concentrations of 16 Polycyclic Aromatic Hydrocarbon (PAH), considered priority by US EPA (US Environmental Protection Agency), in fine particulate matter (PM2.5), were determined in a forest reserve and in an urban area in the city of Rio de Janeiro. The PM2.5 samples were collected in the Tijuca Forest (TF) and on the Maracanã campus of the State University of Rio de Janeiro (UERJ), using PM2.5 high-volume air samplers, from November 2015 to April 2016. The organic matter was extracted, separated by liquid chromatography, and analyzed by gas chromatography-mass spectrometry (GC-MS). The mean total PAH (excluding naphthalene, acenaphthene, and acenaphthylene) concentrations were 0.46?±?0.61 ng m?3 and 1.12?±?0.71 ng m?3 in PM2.5 collected at TF and UERJ, respectively. The diagnostic ratios suggested vehicular sources for both sites with no clear distinction between light and heavy vehicular sources. Cluster and principal component analyses were also used to clarify the possible PAH sources. Simulations of air mass trajectories confirmed the transport of pollutants from the city to the forest. Mutagenicity tests revealed that the PM collected in the UERJ presented mutagenic positive activity, likely for nitro-PAH and amino-PAH, which may be related to vehicular emissions. For the TF, although the forest was impacted by the pollutants, no positive activity was detected. Correlation and cluster analyses showed different PAH distributions for the TF and UERJ sites, which indicates that the TF receives the air masses from the city but is also impacted by local emissions. 相似文献
99.
Juliana Damasceno Oliveira Lígia Nunes de Morais Ribeiro Gustavo Henrique Rodrigues da Silva Bruna Renata Casadei Verônica Muniz Couto Elizabeth Ferreira Martinez Eneida de Paula 《Pharmaceutical research》2018,35(12):229
Purpose
Etidocaine (EDC) is a long lasting local anesthetic, which alleged toxicity has restricted its clinical use. Liposomes can prolong the analgesia time and reduce the toxicity of local anesthetics. Ionic gradient liposomes (IGL) have been proposed to increase the upload and prolong the drug release, from liposomes.Methods
First, a HPLC method for EDC quantification was validated. Then, large unilamellar vesicles composed of hydrogenated soy phosphatidylcholine:cholesterol with 250 mM (NH4)2SO4 - inside gradient - were prepared for the encapsulation of 0.5% EDC. Dynamic light scattering, nanotracking analysis, transmission electron microscopy and electron paramagnetic resonance were used to characterize: nanoparticles size, polydispersity, zeta potential, concentration, morphology and membrane fluidity. Release kinetics and in vitro cytotoxicity tests were also performed.Results
IGLEDC showed average diameters of 172.3?±?2.6 nm, low PDI (0.12?±?0.01), mean particle concentration of 6.3?±?0.5?×?1012/mL and negative zeta values (?10.2?±?0.4 mV); parameters that remain stable during storage at 4°C. The formulation, with 40% encapsulation efficiency, induced the sustained release of EDC (ca. 24 h), while reducing its toxicity to human fibroblasts.Conclusion
A novel formulation is proposed for etidocaine that promotes sustained release and reduces its cytotoxicity. IGLEDC can come to be a tool to reintroduce etidocaine in clinical use.100.
Tarcieli Pozzebon Venturini Abdullah M.S. Al-Hatmi Luana Rossato Maria Isabel Azevedo Jéssica Tairine Keller Carla Weiblen Janio Morais Santurio Sydney Hartz Alves 《International journal of antimicrobial agents》2018,51(5):784-788
The aim of this study was to evaluate the susceptibility of 20 clinical isolates of Fusarium spp. to classic antifungals [amphotericin B (AmB), itraconazole (ITR), voriconazole (VRC) and caspofungin (CAS)] and to non-antifungal agents [amiodarone (AMD), doxycycline (DOX) and moxifloxacin (MFX)] by the broth microdilution method. Combinations between these antifungal and non-antifungal agents were also evaluated to determine the fractional inhibitory concentration indices using the chequerboard technique. Synergistic interactions were observed for the following combinations (% synergism): AMD?+?VRC, 80%; MFX?+?AmB, 75%; AMD?+?AmB, 65%; DOX?+?VRC, 60%; MFX?+?VRC, 55%; DOX?+?AmB, 50%; and AMD?+?CAS, 30%. Synergism was not observed for associations with ITR. Antagonism was not seen in any combination. These findings suggest that the combinations of AMD, DOX or MFX with AmB or VRC to have potential for future in vivo investigations. 相似文献