全文获取类型
收费全文 | 1354篇 |
免费 | 75篇 |
国内免费 | 9篇 |
专业分类
耳鼻咽喉 | 1篇 |
儿科学 | 18篇 |
妇产科学 | 27篇 |
基础医学 | 285篇 |
口腔科学 | 4篇 |
临床医学 | 132篇 |
内科学 | 350篇 |
皮肤病学 | 10篇 |
神经病学 | 166篇 |
特种医学 | 31篇 |
外科学 | 104篇 |
综合类 | 3篇 |
现状与发展 | 1篇 |
一般理论 | 2篇 |
预防医学 | 61篇 |
眼科学 | 13篇 |
药学 | 100篇 |
中国医学 | 5篇 |
肿瘤学 | 125篇 |
出版年
2024年 | 3篇 |
2023年 | 47篇 |
2022年 | 92篇 |
2021年 | 134篇 |
2020年 | 47篇 |
2019年 | 71篇 |
2018年 | 60篇 |
2017年 | 31篇 |
2016年 | 44篇 |
2015年 | 62篇 |
2014年 | 55篇 |
2013年 | 65篇 |
2012年 | 84篇 |
2011年 | 94篇 |
2010年 | 57篇 |
2009年 | 42篇 |
2008年 | 71篇 |
2007年 | 74篇 |
2006年 | 77篇 |
2005年 | 78篇 |
2004年 | 54篇 |
2003年 | 33篇 |
2002年 | 22篇 |
2001年 | 4篇 |
2000年 | 4篇 |
1999年 | 6篇 |
1998年 | 10篇 |
1997年 | 2篇 |
1996年 | 4篇 |
1995年 | 4篇 |
1994年 | 1篇 |
1993年 | 2篇 |
1988年 | 1篇 |
1987年 | 1篇 |
1982年 | 1篇 |
1978年 | 1篇 |
排序方式: 共有1438条查询结果,搜索用时 15 毫秒
11.
12.
Fedor M. Zurabov Ekaterina A. Chernevskaya Natalia V. Beloborodova Alexander Yu. Zurabov Marina V. Petrova Mikhail Ya. Yadgarov Valentina M. Popova Oleg E. Fatuev Vladislav E. Zakharchenko Marina M. Gurkova Ekaterina A. Sorokina Egor A. Glazunov Tatiana A. Kochetova Victoria V. Uskevich Artem N. Kuzovlev Andrey V. Grechko 《Viruses》2022,14(12)
Increasing evidence suggests that gut dysbiosis is associated with coronavirus disease 2019 (COVID-19) infection and may persist long after disease resolution. The excessive use of antimicrobials in patients with COVID-19 can lead to additional destruction of the microbiota, as well as to the growth and spread of antimicrobial resistance. The problem of bacterial resistance to antibiotics encourages the search for alternative methods of limiting bacterial growth and restoring the normal balance of the microbiota in the human body. Bacteriophages are promising candidates as potential regulators of the microbiota. In the present study, two complex phage cocktails targeting multiple bacterial species were used in the rehabilitation of thirty patients after COVID-19, and the effectiveness of the bacteriophages against the clinical strain of Klebsiella pneumoniae was evaluated for the first time using real-time visualization on a 3D Cell Explorer microscope. Application of phage cocktails for two weeks showed safety and the absence of adverse effects. An almost threefold statistically significant decrease in the anaerobic imbalance ratio, together with an erythrocyte sedimentation rate (ESR), was detected. This work will serve as a starting point for a broader and more detailed study of the use of phages and their effects on the microbiome. 相似文献
13.
Julia V. Ershova Grigory V. Volchenkov Dorothy A. Kaminski Tatiana R. Somova Tatiana A. Kuznetsova Natalia V. Kaunetis J. Peter Cegielski Ekaterina V. Kurbatova 《Emerging infectious diseases》2015,21(11):2048-2051
We studied the epidemiology of drug-resistant tuberculosis (TB) in Vladimir Region, Russia, in 2012. Most cases of multidrug-resistant TB (MDR TB) were caused by transmission of drug-resistant strains, and >33% were in patients referred for testing after mass radiographic screening. Early diagnosis of drug resistance is essential for preventing transmission of MDR TB. 相似文献
14.
15.
16.
Mohammed H. Elkomy Pervez Sultan David R. Drover Ekaterina Epshtein Jeffery L. Galinkin Brendan Carvalho 《Antimicrobial agents and chemotherapy》2014,58(6):3504-3513
The objectives of this work were (i) to characterize the pharmacokinetics of cefazolin in pregnant women undergoing elective cesarean delivery and in their neonates; (ii) to assess cefazolin transplacental transmission; (iii) to evaluate the dosing and timing of preoperative, prophylactic administration of cefazolin to pregnant women; and (iv) to investigate the impact of maternal dosing on therapeutic duration and exposure in newborns. Twenty women received 1 g of cefazolin preoperatively. Plasma concentrations of total cefazolin were analyzed from maternal blood samples taken before, during, and after delivery; umbilical cord blood samples obtained at delivery; and neonatal blood samples collected 24 h after birth. The distribution volume of cefazolin was 9.44 liters/h. The values for pre- and postdelivery clearance were 7.18 and 4.12 liters/h, respectively. Computer simulations revealed that the probability of maintaining free cefazolin concentrations in plasma above 8 mg/liter during scheduled caesarean surgery was <50% in the cord blood when cefazolin was administered in doses of <2 g or when it was administered <1 h before delivery. Therapeutic concentrations of cefazolin persisted in neonates >5 h after birth. Cefazolin clearance increases during pregnancy, and larger doses are recommended for surgical prophylaxis in pregnant women to obtain the same antibacterial effect as in nonpregnant patients. Cefazolin has a longer half-life in neonates than in adults. Maternal administration of up to 2 g of cefazolin is effective and produces exposure within clinically approved limits in neonates. 相似文献
17.
Denis A. Mogilenko Oleg Shpynov Prabhakar Sairam Andhey Laura Arthur Amanda Swain Ekaterina Esaulova Simone Brioschi Irina Shchukina Martina Kerndl Monika Bambouskova Zhangting Yao Anwesha Laha Konstantin Zaitsev Samantha Burdess Susan Gillfilan Sheila A. Stewart Marco Colonna Maxim N. Artyomov 《Immunity》2021,54(1):99-115.e12
- Download : Download high-res image (177KB)
- Download : Download full-size image
18.
19.
20.