全文获取类型
收费全文 | 196篇 |
免费 | 11篇 |
国内免费 | 6篇 |
专业分类
儿科学 | 11篇 |
妇产科学 | 2篇 |
基础医学 | 29篇 |
口腔科学 | 10篇 |
临床医学 | 27篇 |
内科学 | 24篇 |
皮肤病学 | 3篇 |
神经病学 | 7篇 |
特种医学 | 2篇 |
外科学 | 67篇 |
综合类 | 1篇 |
预防医学 | 2篇 |
眼科学 | 4篇 |
药学 | 9篇 |
肿瘤学 | 15篇 |
出版年
2023年 | 1篇 |
2022年 | 4篇 |
2021年 | 8篇 |
2019年 | 3篇 |
2018年 | 4篇 |
2017年 | 8篇 |
2016年 | 4篇 |
2015年 | 11篇 |
2014年 | 9篇 |
2013年 | 6篇 |
2012年 | 11篇 |
2011年 | 9篇 |
2010年 | 12篇 |
2009年 | 7篇 |
2008年 | 8篇 |
2007年 | 12篇 |
2006年 | 16篇 |
2005年 | 16篇 |
2004年 | 10篇 |
2003年 | 12篇 |
2002年 | 15篇 |
2001年 | 4篇 |
2000年 | 1篇 |
1999年 | 2篇 |
1998年 | 1篇 |
1997年 | 4篇 |
1996年 | 1篇 |
1992年 | 1篇 |
1988年 | 3篇 |
1987年 | 2篇 |
1986年 | 2篇 |
1981年 | 1篇 |
1978年 | 1篇 |
1977年 | 1篇 |
1968年 | 1篇 |
1966年 | 1篇 |
1964年 | 1篇 |
排序方式: 共有213条查询结果,搜索用时 125 毫秒
51.
Kohki Nishikawa Eichi Narimatsu Motohiko Igarashi Akiyoshi Namiki 《Journal of anesthesia》2009,23(4):520-525
Purpose
We evaluated the effects of sepsis on the neuromuscular blocking actions of d-tubocurarine (dTc) in the lateral cricoarytenoid (LCA) and posterior cricoarytenoid (PCA) muscles, an adductor muscle and an abductor muscle of the vocal cords, respectively, in vitro.Methods
Sepsis was induced in rats by cecal ligation and puncture (CLP) to elicit panperitonitis. Electromyograms (EMGs) and endplate potentials (EPPs) were recorded from the LCA and PCA muscles of CLP-operated septic rats and sham-operated nonseptic rats, using extracellular and intracellular microelectrodes, respectively.Results
EMG and EPP (amplitude and quantum content) were depressed by dTc, but the dTc-induced neuromuscular blocking effects were attenuated by sepsis. The suppressive effects of dTc on EMG and EPP (amplitude and quantum content) were less intense in the LCA muscle than in the PCA muscle under both sepsis and nonsepsis conditions.Conclusion
Our study shows that sepsis has a depressive effect on dTc-induced neuromuscular blocking actions at both the adductor and abductor muscles of vocal cords in the larynx. 相似文献52.
53.
We recently reported the expression of podoplanin in the apical bud of adult mouse incisal tooth. This study was aimed to investigate the distribution of podoplanin-expressing cells in mouse tooth germs at several developing stages. At the bud stage podoplanin was expressed in oral mucous epithelia and in a tooth bud. At the cap stage podoplanin was expressed on inner and outer enamel epithelia but not in mesenchymal cells expressing the neural crest stem cell marker nestin. At the early bell stage nestin and podoplanin were expressed in cervical loop and odontoblasts. At the root formation stage both nestin and podoplanin were weakly expressed in odontoblasts generating radicular dentin. Podoplanin expression was also found in the Hertwig epithelial sheath. These results suggest that epithelial cells of developing tooth germ acquire the ability to express nestin, and that tooth germ epithelial cells maintain the ability to express podoplanin in oral mucous epithelia. The expression of podoplanin in odontoblasts was induced as tooth germ development advanced, but was suppressed with the completion of the primary dentin, suggesting that podoplanin may be involved in the cell growth of odontoblasts. Nestin may function as an intermediate filament that binds podoplanin in odontoblasts. 相似文献
54.
55.
56.
Yama N Takeyama Y Tanno K Nara S Itoh Y Mori K Hase M Kurimoto Y Narimatsu E Koito K Asai Y Hareyama M 《Journal of computer assisted tomography》2005,29(6):760-764
The purpose of this study was to investigate a suitable protocol of contrast-enhanced computed tomography (CECT) in cases with a cardiopulmonary support system. Contrast-enhanced computed tomography with intra-arterial injection (IAI) of contrast medium (CM) via a perfusion cannula showed sufficient contrast enhancement in 2 cases of cardiac decompensation (CD). Contrast-enhanced computed tomography with intravenous injection of CM showed insufficient and delayed contrast enhancement of the aorta in 2 cases of CD and 3 cases of pulseless electrical activity. We encourage administration of CM by means of IAI. 相似文献
57.
The effect of ketamine on CA1-field EPSPs (fEPSPs) in rat hippocampal slices was investigated. Ketamine (100 microM) facilitated fEPSPs at 0.05 Hz. The fEPSP facilitation was suppressed completely by AP-5 and partially by propranolol, and also by an increase in stimulation frequency. These results indicate that ketamine facilitates excitatory synaptic transmission by activating NMDA receptors via beta-adrenoceptors under conditions in which NMDA receptor channel block is slight. 相似文献
58.
59.
Ryuta Kawashima Michikazu Matsumura Norihiro Sadato Eichi Naito Atsuo Waki Satoshi Nakamura Kenichi Matsunami Hiroshi Fukuda Yoshiharu Yonekura 《The European journal of neuroscience》1998,10(7):2254-2260
The purpose of this study was to investigate the cortical motor areas activated in relation to unilateral complex hand movements of either hand, and the motor area related to motor skill learning. Regional cerebral blood flow (rCBF) was measured in eight right-handed healthy male volunteers using positron emission tomography during a two-ball-rotation task using the right hand, the same task using the left hand and two control tasks. In the two-ball-rotation tasks, subjects were required to rotate the same two iron balls either with the right or left hand. In the control task, they were required to hold two balls in each hand without movement. The primary motor area, premotor area and cerebellum were activated bilaterally with each unilateral hand movement. In contrast, the supplementary motor area proper was activated only by contralateral hand movements. In addition, we found a positive correlation between the rCBF to the premotor area and the degree of improvement in skill during motor task training. The results indicate that complex hand movements are organized bilaterally in the primary motor areas, premotor areas and cerebellum, that functional asymmetry in the motor cortices is not evident during complex finger movements, and that the premotor area may play an important role in motor skill learning. 相似文献
60.
Nakahata T Tanaka H Tsuruga K Shimada J Tsugawa K Suzuki K Onodera N Ito E 《The Tohoku journal of experimental medicine》2003,200(3):151-154
A previously healthy Japanese girl aged 4 years suddenly developed idiopathic nephrotic syndrome (INS) associated with acute renal failure (ARF). Despite prompt initiation of hemodialysis and prednisolone treatment, her ARF did not recover. A percutaneous renal biopsy performed within a month from the onset of INS revealed lesions of end-stage kidney, which is unusual for the acute stage of INS. Although the etiology of her ARF remains speculative, an acute exacerbation of an underlying chronic disease, such as non-nephrotic focal segmental glomerulosclerosis might be the cause. 相似文献