全文获取类型
收费全文 | 428篇 |
免费 | 13篇 |
国内免费 | 3篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 3篇 |
妇产科学 | 47篇 |
基础医学 | 56篇 |
口腔科学 | 2篇 |
临床医学 | 21篇 |
内科学 | 60篇 |
皮肤病学 | 7篇 |
神经病学 | 35篇 |
特种医学 | 16篇 |
外科学 | 89篇 |
综合类 | 1篇 |
预防医学 | 17篇 |
眼科学 | 3篇 |
药学 | 10篇 |
肿瘤学 | 67篇 |
出版年
2023年 | 2篇 |
2022年 | 5篇 |
2021年 | 8篇 |
2020年 | 7篇 |
2019年 | 11篇 |
2018年 | 12篇 |
2017年 | 3篇 |
2016年 | 5篇 |
2015年 | 5篇 |
2014年 | 14篇 |
2013年 | 27篇 |
2012年 | 18篇 |
2011年 | 40篇 |
2010年 | 24篇 |
2009年 | 12篇 |
2008年 | 30篇 |
2007年 | 28篇 |
2006年 | 33篇 |
2005年 | 21篇 |
2004年 | 27篇 |
2003年 | 20篇 |
2002年 | 23篇 |
2001年 | 20篇 |
2000年 | 12篇 |
1999年 | 5篇 |
1998年 | 7篇 |
1997年 | 4篇 |
1995年 | 3篇 |
1994年 | 2篇 |
1993年 | 2篇 |
1992年 | 3篇 |
1990年 | 3篇 |
1989年 | 3篇 |
1987年 | 2篇 |
1985年 | 1篇 |
1984年 | 1篇 |
1981年 | 1篇 |
排序方式: 共有444条查询结果,搜索用时 15 毫秒
61.
Prognostic factors in carcinoma of the vulva 总被引:2,自引:1,他引:1
John Boyce M.D. Rachel G. Fruchter Ph.D. Efthimios Kasambilides M.D. Anthony D. Nicastri M.D. Alexander Sedlis M.D. Jean Claude Remy M.D. 《Gynecologic oncology》1985,20(3):364-377
The clinical and pathologic characteristics of epidermoid carcinoma of the vulva in 84 women treated by vulvectomy were evaluated in relation to inguinal node status and survival. Tumor diameter, depth of invasion, clinical node status, vascular invasion, and pattern of invasion were all individually correlated with the pathologic status of the inguinal nodes. However, when evaluated in combination, only the clinical status of the inguinal nodes, the depth of invasion, and the pattern of invasion (in this order of significance) were predictive of pathologic inguinal node status. Tumor diameter, inguinal node status, depth of invasion, pattern of invasion, and vascular invasion were individually correlated with survival. When evaluated in combination, the clinical diameter of the lesion was the most important predictor of survival; depth of invasion and vascular invasion contributed additional information. 相似文献
62.
An 82-year-old man was transferred to our emergency department due to acute abdominal pain. He had undergone an endovascular abdominal aortic aneurysm repair (EVAR) six years ago. An intravenous contrast-enhanced abdominal computed tomography revealed the rupture of the abdominal aortic aneurysm (AAA) with a large retroperitoneal hematoma. A Talent (Medtronic, Santa Rosa, CA, USA) modular bifurcated endoprosthesis had vertically collapsed approximately 7 cm after losing its infrarenal fixation. As a result, it led to the repressurization of the aneurysm sac and rupture. The patient was successfully treated by placing three Talent (Medtronic) aortic cuffs. To our knowledge, this is the first reported case of endograft collapse that has manifested with aortic aneurysm rupture. Although they are gradually declining, considerable rates of complications create the 'Achilles' heel' of endovascular repair of AAAs. A lifelong follow-up strategy for patients treated for AAA with EVAR is essential for the early detection and treatment of complications of the procedure. 相似文献
63.
64.
Karadimas EJ Nicolson T Kakagia DD Matthews SJ Richards PJ Giannoudis PV 《International orthopaedics》2011,35(9):1381-1390
Purpose
The purpose of this study was to evaluate the relation between pelvic fracture patterns and the angiographic findings, and to assess the effectiveness of the embolisation. 相似文献65.
Theodorakis G Katsikis A Livanis E Kostopoulou A Adamopoulos S Tsiapras D Voudris V 《Pacing and clinical electrophysiology : PACE》2011,34(11):1553-1560
Background: We aimed at evaluating the long‐term effects of cardiac resynchronization therapy (CRT) in nonambulatory New York Heart Association (NYHA) IV heart failure patients (NAIVHFP). Methods: Eighteen patients, 15 men and three women, eight with ischemic and 10 with nonischemic cardiomyopathy, who underwent biventricular pacemaker implantation while they were in nonambulatory NYHA IV class, were studied. Patients’ age was 58 ± 9 years and left ventricular ejection fraction (LVEF) 18 ± 3 %. Follow‐up data were obtained through review of follow‐up visits notes, stored echocardiographic studies, device interrogation data, and death certificates. Results: After a mean duration of 1223 ± 846 days, 11 patients were alive, including five patients who underwent heart transplantation (OCT) and seven dead. Three of 11 patients who received a CRT‐defibrillator, experienced at least one appropriate discharge, but eventually they either died or received an OCT during follow‐up. Sustained improvements in NYHA class (Z = 2.4, P = 0.015) and 6‐minute walk distance (0 vs 212 ± 95 m, P ? 0.001) were documented after a median duration of 855 days postimplantation. Cumulative proportion of death or OCT at 18 months—when full follow‐up data were available—was 18%, which compared favorably with historical controls. Full echocardiographic and clinical follow‐up data at 12‐months postimplantation were available for 10 patients, documenting a significant reduction in end‐systolic volume (248 ± 82 vs 269 ± 97 mL, P = 0.039). Conclusions: CRT can be safely applied in this subset of extreme severity heart failure patients, achieving encouraging survival rates and reverse remodeling effects. These observations can form an evidence‐based rationale for including NAIVHFP in randomized CRT trials. (PACE 2011; 34:1553–1560) 相似文献
66.
Michael I. Koukourakis Christos Kakouratos Dimitra Kalamida Zoi Bampali Sophia Mavropoulou Efthimios Sivridis 《International journal of radiation biology》2016,92(7):353-363
Purpose: To assess whether anaerobic metabolism, proliferation activity and stem cell content are linked with radioresistance in bladder cancer. Materials and methods: Tissue sections from 66 patients with invasive transitional cell bladder cancer treated with hypofractionated accelerated radiotherapy, was immunohistochemically analyzed for the Hypoxia-Inducible Factor 1α (HIF1α) and the anaerobic glycolysis enzyme lactate dehydrogenase 5 (LDH5). Proliferation index (Ki-67) and stem-cell marker (cluster of differentiation CD44, aldehyde dehydrogenase ALDH1) expression was also examined. Results: Both HIF1α and LDH5 expression were linked with high CD44 stem cell population (p?=?0.001 and 0.05, respectively), while high Ki-67 proliferation index was linked with nuclear LDH5 expression (p?=?0.03) and high histological grade (p?=?0.02). A strong significant association of HIF1α (p?=?0.0009) and of LDH5 (p?0.0001) with poor local relapse free survival (LRFS) was noted, which was also confirmed in multivariate analysis. A significant association with overall survival was also noted. Silencing of lactate dehydrogenase LDHA gene in the human RT112 bladder cancer cell line, or exposure to oxamate (LDH activity inhibitor), resulted in strong radio-sensitization. Conclusions: HIF1α and LDH5 are markers of poor outcome in patients with bladder cancer treated with radiotherapy. Blockage of anaerobic metabolism may prove of importance in clinical radiotherapy. 相似文献
67.
A Giatromanolaki M I Koukourakis E Sivridis K O'Byrne G Cox P E Thorpe K C Gatter A L Harris 《Clinical cancer research》2000,6(5):1917-1921
We investigated the expression of MUC1 protein and its relationship to the microvessel density and the expression of thymidine phosphorylase, vascular endothelial growth factor (VEGF), VEGF-receptor KDR, basic fibroblast growth factor (bFGF), and bFGF-receptor (FGFR-2) in non-small cell lung cancer. Although MUC1 expression was found equally in poorly and highly vascularized tumors, a significant coexpression with multiple angiogenic factors and their receptors was noted (P = 0.0002, 0.03, 0.19, 0.10, and 0.01 for thymidine phosphorylase, VEGF, KDR, bFGF, and FGFR-2, respectively). In multiple regression analysis, both angiogenesis and MUC1 expression were independent prognostic variables. The present study suggests the existence of an early genetic event leading to the activation of both migration and angiogenesis pathways in non-small cell lung cancer. 相似文献
68.
Efthimios EleftheriadisM.D. Katerina KotzampassiM.D. Dimitris KoufogiannisPh.D. 《The American journal of gastroenterology》1998,93(12):2431-2435
Objective: In this study the effect of the hemorheological agent pentoxifylline on the pressure of esophageal varices was investigated in portal hypertensive cirrhotic patients.
Methods: Intravariceal pressure was measured endoscopically using the direct puncture technique in 20 patients. Measurements were obtained under baseline conditions and 30 min after double-blind administration of pentoxifylline (1.4 mg/kg BW, n = 10 patients) or an indentical volume of NaCl 0.9% solution (n = 10 patients).
Results: Under baseline conditions, intravariceal pressure was similar in pentoxifylline and placebo groups (17.3 ± 5.5 mm Hg vs 18.8 ± 4.6 mm Hg, respectively; p = N.S. ). Placebo administration had no significant effect on intravariceal pressure (18.8 ± 4.6 mm Hg vs 18.3 ± 4.1 mm Hg; p = N.S. ). In contrast, pentoxifylline caused a highly significant reduction of intravariceal pressure, (from 17.3 ± 5.5 mm Hg to 11.4 ± 5.9 mm Hg; p = 0.0001 ), the overall mean reduction being 36.1 ± 14.1% mm Hg.
Conclusion: We concluded that pentoxifylline, by reducing blood flow viscosity, caused a significant decrease in variceal pressure in patients suffering from portal hypertension. 相似文献
Methods: Intravariceal pressure was measured endoscopically using the direct puncture technique in 20 patients. Measurements were obtained under baseline conditions and 30 min after double-blind administration of pentoxifylline (1.4 mg/kg BW, n = 10 patients) or an indentical volume of NaCl 0.9% solution (n = 10 patients).
Results: Under baseline conditions, intravariceal pressure was similar in pentoxifylline and placebo groups (17.3 ± 5.5 mm Hg vs 18.8 ± 4.6 mm Hg, respectively; p = N.S. ). Placebo administration had no significant effect on intravariceal pressure (18.8 ± 4.6 mm Hg vs 18.3 ± 4.1 mm Hg; p = N.S. ). In contrast, pentoxifylline caused a highly significant reduction of intravariceal pressure, (from 17.3 ± 5.5 mm Hg to 11.4 ± 5.9 mm Hg; p = 0.0001 ), the overall mean reduction being 36.1 ± 14.1% mm Hg.
Conclusion: We concluded that pentoxifylline, by reducing blood flow viscosity, caused a significant decrease in variceal pressure in patients suffering from portal hypertension. 相似文献
69.
70.
Sotirios G. Tsiogkas Maria G. Grammatikopoulou Konstantinos Gkiouras Efterpi Zafiriou Iordanis Papadopoulos Christos Liaskos Efthimios Dardiotis Lazaros I. Sakkas Dimitrios P. Bogdanos 《Nutrients》2021,13(12)
Rheumatic diseases (RDs) are often complicated by chronic symptoms and frequent side-effects associated with their treatment. Saffron, a spice derived from the Crocus sativus L. flower, is a popular complementary and alternative medicine among patients with RDs. The present systematic review aimed to summarize the available evidence regarding the efficacy of supplementation with saffron on disease outcomes and comorbidities in patients with RD diagnoses. PubMed, CENTRAL, clinicaltrials.gov and the grey literature were searched until October 2021, and relevant randomized controlled trials (RCTs) were screened for eligibility using Rayyan. Risk of bias was assessed using the Cochrane’s Risk of Bias-2.0 (RoB) tool. A synthesis without meta-analysis (SWiM) was performed by vote counting and an effect direction plot was created. Out of 125 reports, seven fulfilled the eligibility criteria belonging to five RCTs and were included in the SWiM. The RCTs involved patients with rheumatoid arthritis, osteoarthritis and fibromyalgia, and evaluated outcomes related to pain, disease activity, depression, immune response, inflammation, oxidative stress, health, fatigue and functional ability. The majority of trials demonstrated some concerns regarding overall bias. Moreover, the majority of trialists failed to adhere to the formula elaborations suggested by the CONSORT statement for RCTs incorporating herbal medicine interventions. Standardization of herbal medicine confirms its identity, purity and quality; however, the majority of trials failed to adhere to these guidelines. Due to the great heterogeneity and the lack of important information regarding the standardization and content of herbal interventions, it appears that the evidence is not enough to secure a direction of effect for any of the examined outcomes. 相似文献