全文获取类型
收费全文 | 1224篇 |
免费 | 87篇 |
国内免费 | 2篇 |
专业分类
耳鼻咽喉 | 10篇 |
儿科学 | 134篇 |
妇产科学 | 74篇 |
基础医学 | 195篇 |
口腔科学 | 33篇 |
临床医学 | 85篇 |
内科学 | 198篇 |
皮肤病学 | 8篇 |
神经病学 | 125篇 |
特种医学 | 16篇 |
外科学 | 108篇 |
综合类 | 24篇 |
一般理论 | 2篇 |
预防医学 | 102篇 |
眼科学 | 10篇 |
药学 | 61篇 |
中国医学 | 1篇 |
肿瘤学 | 127篇 |
出版年
2023年 | 13篇 |
2022年 | 22篇 |
2021年 | 36篇 |
2020年 | 14篇 |
2019年 | 21篇 |
2018年 | 22篇 |
2017年 | 17篇 |
2016年 | 21篇 |
2015年 | 27篇 |
2014年 | 32篇 |
2013年 | 39篇 |
2012年 | 57篇 |
2011年 | 57篇 |
2010年 | 36篇 |
2009年 | 43篇 |
2008年 | 60篇 |
2007年 | 69篇 |
2006年 | 60篇 |
2005年 | 51篇 |
2004年 | 43篇 |
2003年 | 49篇 |
2002年 | 38篇 |
2001年 | 27篇 |
2000年 | 45篇 |
1999年 | 28篇 |
1998年 | 17篇 |
1997年 | 7篇 |
1996年 | 13篇 |
1995年 | 15篇 |
1994年 | 11篇 |
1993年 | 18篇 |
1992年 | 36篇 |
1991年 | 23篇 |
1990年 | 25篇 |
1989年 | 21篇 |
1988年 | 21篇 |
1987年 | 22篇 |
1986年 | 17篇 |
1985年 | 20篇 |
1984年 | 15篇 |
1983年 | 15篇 |
1982年 | 11篇 |
1981年 | 5篇 |
1980年 | 4篇 |
1979年 | 7篇 |
1977年 | 4篇 |
1976年 | 5篇 |
1974年 | 4篇 |
1973年 | 5篇 |
1967年 | 6篇 |
排序方式: 共有1313条查询结果,搜索用时 15 毫秒
21.
22.
Jeroen N. Stoop Christopher A. Tibbitt Willem van Eden John H. Robinson Catharien M. U. Hilkens 《Immunology》2013,138(1):68-75
Rheumatoid arthritis (RA) is a debilitating autoimmune disease characterized by chronic inflammation of the synovial joints. Collagen‐induced arthritis (CIA) and proteoglycan‐induced arthritis (PGIA) are mouse models of inflammatory arthritis; CIA is a T helper type 17 (Th17) ‐dependent disease that is induced with antigen in complete Freund's adjuvant, whereas PGIA is Th1‐mediated and is induced using antigen in dimethyldioctadecyl‐ammonium bromide (DDA) as an adjuvant. To investigate whether the type of adjuvant determines the cytokine profile of the pathogenic T cells, we have compared the effect of CFA and DDA on T‐cell responses in a single arthritis model. No differences in incidence or disease severity between aggrecan‐T‐cell receptor transgenic mice immunized with aggrecan in either CFA or DDA were observed. Immunization with CFA resulted in a higher proportion of Th17 cells, whereas DDA induced more Th1 cells. However, the levels of interleukin‐17 (IL‐17) produced by T cells isolated from CFA‐immunized mice after antigen‐specific stimulation were not significantly different from those found in DDA‐immunized mice, indicating that the increased proportion of Th17 cells did not result in significantly higher ex vivo IL‐17 levels. Hence, the choice of adjuvant can affect the overall proportions of Th1 and Th17 cells, without necessarily affecting the level of cytokine production or disease incidence and severity. 相似文献
23.
Browne Julia Cather Corinne Zvonar Vanya Thayer Katherine Skiest Hannah Arntz Diana Kritikos Katherine Schnitzer Kristina Brown Hannah Evins A. Eden Donovan Abigail 《Community mental health journal》2021,57(5):864-871
Community Mental Health Journal - The mortality disparity for persons with schizophrenia spectrum disorders (SSDs) due to cardiovascular disease is a devastating problem. Many risk factors are... 相似文献
24.
On the question of the integration of exogenous bacterial DNA into plant DNA. 总被引:5,自引:0,他引:5 下载免费PDF全文
A Kleinhofs F C Eden M D Chilton A J Bendich 《Proceedings of the National Academy of Sciences of the United States of America》1975,72(7):2748-2752
Extensive studies with pea, tomato, and barley failed to confirm the evidence presented by previous investigators for integration or replication of exogenously applied bacterial DNA in these plants. Labeled DNA of buoyant density in CsCl intermediate between that of high density donor bacterial DNA and of plant DNA was never observed with axenic plants. Intermediate peaks, similar to those used as evidence for recombination by earlier investigators, were observed only when the plants were contaminated with bacteria. Plant DNA prepared by a published procedure [Ledoux, L. & Huart, R. (1969) J. Mol. Biol. 43, 243-262] was found to be contaminated with unidentified impurities. Such DNA was partially protected from the action of DNase and produced aberrant banding patterns in CsCl after shearing. Much of the published evidence for integration of foreign DNA in plants is based upon experiments with plant DNA prepared by this procedure. We conclude that contamination is the likely explanation for what has been interpreted as evidence for integration. 相似文献
25.
Lena Nordström Sandra Sernbo Patrik Eden Kirsten Grønbæk Arne Kolstad Riikka Räty Marja‐Liisa Karjalainen Christian Geisler Elisabeth Ralfkiær Christer Sundström Anna Laurell Jan Delabie Mats Ehinger Mats Jerkeman Sara Ek 《British journal of haematology》2014,166(1):98-108
Mantle cell lymphoma (MCL) is an aggressive B cell lymphoma, where survival has been remarkably improved by use of protocols including high dose cytarabine, rituximab and autologous stem cell transplantation, such as the Nordic MCL2/3 protocols. In 2008, a MCL international prognostic index (MIPI) was created to enable stratification of the clinical diverse MCL patients into three risk groups. So far, use of the MIPI in clinical routine has been limited, as it has been shown that it inadequately separates low and intermediate risk group patients. To improve outcome and minimize treatment‐related morbidity, additional parameters need to be evaluated to enable risk‐adapted treatment selection. We have investigated the individual prognostic role of the MIPI and molecular markers including SOX11, TP53 (p53), MKI67 (Ki‐67) and CCND1 (cyclin D1). Furthermore, we explored the possibility of creating an improved prognostic tool by combining the MIPI with information on molecular markers. SOX11 was shown to significantly add prognostic information to the MIPI, but in multivariate analysis TP53 was the only significant independent molecular marker. Based on these findings, we propose that TP53 and SOX11 should routinely be assessed and that a combined TP53/MIPI score may be used to guide treatment decisions. 相似文献
26.
27.
28.
Joost Smolders Ester B. M. Remmerswaal Karianne G. Schuurman Jeroen Melief Corbert G. van Eden René A. W. van Lier Inge Huitinga Jörg Hamann 《Acta neuropathologica》2013,126(4):525-535
Immune surveillance of the central nervous system (CNS) by T cells is important to keep CNS-trophic viruses in a latent state, yet our knowledge of the characteristics of CNS-populating T cells is incomplete. We performed a comprehensive, multi-color flow-cytometric analysis of isolated T cells from paired corpus callosum (CC) and peripheral blood (PB) samples of 20 brain donors. Compared to PB, CC T cells, which were mostly located in the perivascular space and sporadically in the parenchyma, were enriched for cells expressing CD8. Both CD4+ and CD8+ T cells in the CC had a late-differentiated phenotype, as indicated by lack of expression of CD27 and CD28. The CC contained high numbers of T cells expressing chemokine receptor CX3CR1 and CXCR3 that allow for homing to inflamed endothelium and tissue, but hardly cells expressing the lymph node-homing receptor CCR7. Despite the late-differentiated phenotype, CC T cells had high expression of the IL-7 receptor α-chain CD127 and did not contain the neurotoxic cytolytic enzymes perforin, granzyme A, and granzyme B. We postulate that CNS T cells make up a population of tissue-adapted differentiated cells, which use CX3CR1 and CXCR3 to home into the perivascular space, use IL-7 for maintenance, and lack immediate cytolytic activity, thereby preventing immunopathology in response to low or non-specific stimuli. The presence of these cells in this tightly regulated environment likely enables a fast response to local threats. Our results will enable future detailed exploration of T-cell subsets in the brain involved in neurological diseases. 相似文献
29.
Properties of global‐ and local‐ancestry adjustments in genetic association tests in admixed populations 下载免费PDF全文
Eden R. Martin Ilker Tunc Zhi Liu Susan H. Slifer Ashley H. Beecham Gary W. Beecham 《Genetic epidemiology》2018,42(2):214-229
Population substructure can lead to confounding in tests for genetic association, and failure to adjust properly can result in spurious findings. Here we address this issue of confounding by considering the impact of global ancestry (average ancestry across the genome) and local ancestry (ancestry at a specific chromosomal location) on regression parameters and relative power in ancestry‐adjusted and ‐unadjusted models. We examine theoretical expectations under different scenarios for population substructure; applying different regression models, verifying and generalizing using simulations, and exploring the findings in real‐world admixed populations. We show that admixture does not lead to confounding when the trait locus is tested directly in a single admixed population. However, if there is more complex population structure or a marker locus in linkage disequilibrium (LD) with the trait locus is tested, both global and local ancestry can be confounders. Additionally, we show the genotype parameters of adjusted and unadjusted models all provide tests for LD between the marker and trait locus, but in different contexts. The local ancestry adjusted model tests for LD in the ancestral populations, while tests using the unadjusted and the global ancestry adjusted models depend on LD in the admixed population(s), which may be enriched due to different ancestral allele frequencies. Practically, this implies that global‐ancestry adjustment should be used for screening, but local‐ancestry adjustment may better inform fine mapping and provide better effect estimates at trait loci. 相似文献
30.
Karen Nuytemans PhD Vanessa Inchausti BS Gary W. Beecham PhD Liyong Wang PhD Dennis W. Dickson MD John Q. Trojanowski MD PhD Virginia M.‐Y. Lee PhD Deborah C. Mash PhD Matthew P. Frosch MD PhD Tatiana M. Foroud PhD Lawrence S. Honig MD PhD Thomas J. Montine MD PhD Ted M. Dawson MD PhD Eden R. Martin PhD William K. Scott PhD Jeffery M. Vance MD PhD 《Movement disorders》2014,29(6):827-830