全文获取类型
收费全文 | 2286800篇 |
免费 | 167737篇 |
国内免费 | 3356篇 |
专业分类
耳鼻咽喉 | 31601篇 |
儿科学 | 75605篇 |
妇产科学 | 65743篇 |
基础医学 | 336558篇 |
口腔科学 | 64495篇 |
临床医学 | 205160篇 |
内科学 | 443882篇 |
皮肤病学 | 48468篇 |
神经病学 | 181399篇 |
特种医学 | 87286篇 |
外国民族医学 | 602篇 |
外科学 | 338900篇 |
综合类 | 48223篇 |
现状与发展 | 4篇 |
一般理论 | 823篇 |
预防医学 | 180010篇 |
眼科学 | 52254篇 |
药学 | 171321篇 |
8篇 | |
中国医学 | 4091篇 |
肿瘤学 | 121460篇 |
出版年
2018年 | 22776篇 |
2016年 | 19168篇 |
2015年 | 22260篇 |
2014年 | 30746篇 |
2013年 | 47000篇 |
2012年 | 64221篇 |
2011年 | 68632篇 |
2010年 | 40133篇 |
2009年 | 38307篇 |
2008年 | 65555篇 |
2007年 | 70562篇 |
2006年 | 70899篇 |
2005年 | 69491篇 |
2004年 | 66894篇 |
2003年 | 64309篇 |
2002年 | 63022篇 |
2001年 | 100043篇 |
2000年 | 102481篇 |
1999年 | 86857篇 |
1998年 | 24994篇 |
1997年 | 22432篇 |
1996年 | 22893篇 |
1995年 | 21718篇 |
1994年 | 20473篇 |
1993年 | 18968篇 |
1992年 | 69983篇 |
1991年 | 69020篇 |
1990年 | 67735篇 |
1989年 | 65640篇 |
1988年 | 61152篇 |
1987年 | 60050篇 |
1986年 | 57287篇 |
1985年 | 54523篇 |
1984年 | 41106篇 |
1983年 | 35795篇 |
1982年 | 21441篇 |
1981年 | 19297篇 |
1979年 | 39447篇 |
1978年 | 28322篇 |
1977年 | 24072篇 |
1976年 | 22564篇 |
1975年 | 24596篇 |
1974年 | 29442篇 |
1973年 | 28674篇 |
1972年 | 27208篇 |
1971年 | 25374篇 |
1970年 | 23766篇 |
1969年 | 22714篇 |
1968年 | 21287篇 |
1967年 | 18960篇 |
排序方式: 共有10000条查询结果,搜索用时 12 毫秒
51.
Baha’ N. Noureddin Christiane E. Al-Haddad Ziad Bashshur Bared Safieh-Garabedian 《Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie》2006,244(6):750-752
Background The objective was to measure the plasma concentrations of thymulin and nerve growth factor (NGF) in a group of patients with primary open angle glaucoma (POAG) and compare them with age- and sex-matched normal controls.Methods Twenty-eight patients newly diagnosed with POAG who were not undergoing treatment were compared with the same number of age- and sex-matched healthy controls. Blood samples were drawn into heparinized tubes and plasma samples were collected for the determination of the concentrations of thymulin and NGF, using specific enzyme-linked immunosorbent assay (ELISA). The Student’s t test was used to perform the necessary statistical analysis of the results.Results Seventeen women and 11 men were enrolled in each of the two groups (study and control), with a mean age of 63.7 (SD 10.3) years in the former and 63.3 (SD 9.6) years in the latter. There was a highly significant (p<0.001) elevation in the thymulin levels in POAG patients compared with the control group. However, no significant difference was observed when comparing the plasma NGF levels.Conclusion This is the first report to measure plasma thymulin levels in glaucoma patients. The significant results point the possible role of this immunomodulator in the pathogenesis of primary open angle glaucoma. The potential role of NGF seems to be less likely. These findings warrant further investigation. 相似文献
52.
Marlene L Hauck Susan M LaRue William P Petros Jean M Poulson Daohai Yu Ivan Spasojevic Amy F Pruitt Allison Klein Beth Case Donald E Thrall David Needham Mark W Dewhirst 《Clinical cancer research》2006,12(13):4004-4010
PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicities, and pharmacokinetic characteristics of doxorubicin encapsulated in a low temperature sensitive liposome (LTSL) when given concurrently with local hyperthermia to canine solid tumors. EXPERIMENTAL DESIGN: Privately owned dogs with solid tumors (carcinomas or sarcomas) were treated. The tumors did not involve bone and were located at sites amenable to local hyperthermia. LTSL-doxorubicin was given (0.7-1.0 mg/kg i.v.) over 30 minutes during local tumor hyperthermia in a standard phase I dose escalation study. Three treatments, given 3 weeks apart, were scheduled. Toxicity was monitored for an additional month. Pharmacokinetics were evaluated during the first treatment cycle. RESULTS: Twenty-one patients were enrolled: 18 with sarcomas and 3 with carcinomas. Grade 4 neutropenia and acute death secondary to liver failure, possibly drug related, were the dose-limiting toxicities. The maximum tolerated dose was 0.93 mg/kg. Other toxicities, with the possible exception of renal damage, were consistent with those observed following free doxorubicin administration. Of the 20 dogs that received > or = 2 doses of LTSL-doxorubicin, 12 had stable disease, and 6 had a partial response to treatment. Pharmacokinetic variables were more similar to those of free doxorubicin than the marketed liposomal product. Tumor drug concentrations at a dose of 1.0 mg/kg averaged 9.12 +/- 6.17 ng/mg tissue. CONCLUSION: LTSL-doxorubicin offers a novel approach to improving drug delivery to solid tumors. It was well tolerated and resulted in favorable response profiles in these patients. Additional evaluation in human patients is warranted. 相似文献
53.
54.
55.
K M Sarraf M Abdalla O Al-Omari M G Sarraf 《Ultrasound in obstetrics & gynecology》2006,27(2):220-221
We report the case of a 38-year-old woman who presented with chronic lower abdominal pain. Her past medical history included a splenectomy due to abdominal trauma. Ultrasound examination revealed four pelvic tumors which, upon laparotomy, were found to be the result of splenosis. Approximately 100 cases of splenosis have been reported but only a minority of them have been published in the gynecological literature. Our case indicates that those involved in pelvic scanning (even of asymptomatic women) and/or treating those complaining of lower abdominal pain or presenting with pelvic tumors should be aware of splenosis as a possible diagnosis. 相似文献
56.
57.
58.
59.
60.
M Ugras† G Kocak† H Ozcan‡ 《Journal of the European Academy of Dermatology and Venereology》2006,20(9):1126-1128
Neu-Laxova syndrome (NLS) is a rare autosomal recessive syndrome, characterized by severe intrauterine growth retardation (IUGR), microcephaly, abnormal brain development, oedema and ichthyosis. It was first reported in 1971 by Neu et al. (Pediatrics 47: 610-612) and since then no more than 60 cases have been reported. A newborn girl delivered from a 29-year-old healthy mother was admitted to hospital with a thick membrane covering her body and dismorphic appearance. The diagnosis of NLS was made according to characteristic features. The syndrome is known to have a poor prognosis and the baby lived for 9 weeks. This case is one of the longest living cases of NLS and the fourth case reported from Turkey. 相似文献