Infant feeding, wheezing, and allergy: a prospective study

The determinants of wheezing and allergy were investigated in 453 children with a family history of allergic disease. A randomised controlled trial examined the effects of withholding cows' milk protein during the first three months of life and replacing cows' milk with soya milk. The children were followed up to the age of 7 years. Withholding cows' milk did not reduce the incidence of allergy or wheezing. Children who had ever been breast fed had a lower incidence of wheeze than those who had not (59% and 74% respectively). The effect persisted to age 7 years in the non-atopics only, the risk of wheeze being halved in the breast fed children after allowing for employment status, sex passive smoking, and overcrowding. Allergic disease was not associated with exposure to tobacco smoke, house dust mite antigen, or cats. Breast feeding may confer long term protection against respiratory infection.     

A study of the fasciocutaneous vascularisation of the arm surgical applications

Summary The data on the fasciocutaneous vascularisation of the medial aspect of the arm are incomplete in the literature. This study presents the methodology and results of an anatomic study on 19 upper limbs with arterial injection. The vascularisation of the upper part of this region is provided in 68% of cases by the superficial fasciocutaneous branch (SFCB) of the superior ulnar collateral artery (SUC), that of the middle and lower part by 3–4 fasciocutaneous pedicles originating from the SUC which are prolonged distally by the recurrent posterior ulnar artery. The SFCB has important relations with the ulnar nerve; it travels dorsal to the nerve in 64% of cases and then allows the raising of a distally-pedicled ulnar flap with a 3 : 1 ratio. In other anatomic configurations, a flap with retrograde flow supplied by the inferior pedicles of the SUC can always be raised. Its ratio is then 2 : 1. this flap allows coverage of all cases of posterior or anterior losses of substance at the elbow. These results supplement the data required for the raising of a distally-pedicled medial brachial flap. but also of a proximally-pedicled superior medial brachial flap and of a free superior medial brachial flap transposed by microsurgical means.

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Etude de la vascularisation fasciocutanée de la face médiale du bras. Applications chirurgicales

Résumé Les connaissances sur la vascularisation fascio-cutanée de la face médiale du bras sont incomplètes dans la littérature. Cette étude présente la méthodologie et les résultats d'une étude anatomique sur 19 membres thoraciques avec injection artérielle. La vascularisation de la partie supérieure de cette région est assurée dans 68% des cas par la branche superficielle fasciocutanée (BSFC) de l'a. collatérale ulnaire supérieure (CUS), celle des parties moyenne et inférieure par 3 ou 4 pédicules fascio-cutanés issus de la CUS, qui se prolongent distalement par le rameau postérieur de l'a. récurrente ulnaire. La BSFC contracte des rapports importants avec le n. ulnaire, elle passe à la face dorsale du nerf dans 64% des cas et permet alors la levée d'un lambeau ulnaire à pédicule distal de ratio 3 sur 1. Dans les autres configurations anatomiques, un lambeau à flux rétrograde vascularisé par les pédicules inférieurs de la CUS est toujours prélevable. Son ratio est alors de 2 sur 1. Ce lambeau permet dans tous les cas la couverture de pertes de substance postérieures ou antérieures du coude. Ces résultats permettent de compléter les connaissances nécessaires à la levée du lambeau brachial médial à pédicule distal, mais aussi du lambeau brachial médial supérieur à pédicule proximal et du lambeau libre brachial médial supérieur transposé par méthode microchirurgicale.

     

V̇ max and nutritional status in Urban Colombian girls and women

Maximal oxygen consumption (V? max, liters min^?1) was measured in 60 nutritionally normal and 74 marginally undernourished girls 6–16 years of age and 27 upper socioeconomic (UEC) women and 22 women living in economically deprived conditions (LEC) in Cali, Colombia. All girls were recruited from the LEC neighborhoods. Lower values for V? max (liters min^?1) in undernourished girls were replaced by a nutritionally normal status in adulthood in which V? max was not significantly different from that measured in UEC women. Physical condition varied from average to fair in the younger to older subjects compared to women from industrialized countries. When V? max is expressed as ml min^?1 kg^?1 of lean body mass (LBM), all age and group effects disappear, confirming regression analysis which demonstrated a close relationship (r² = 0.81) between V? max (liters min^?1) and LBM in which there were no significant differences between nutritional or socioeconomic groups. © 1994 Wiley-Liss, Inc.     

Comparative anatomy and histology of the radial artery and the internal thoracic artery

Summary Anatomical characteristics of the radial a. were compared to those of the internal thoracic a., considered as a gold standard in coronary surgery. The length, the diameter, the collateral distribution and the wall thickness of these two arteries were studied comparatively. In addition, a comparative histological analysis was carried out. Anatomical and histological characteristics of these two arteries have important implications for coronary artery bypass.

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Anatomie et histologie comparative de l'artère radiale et de l'artère thoracique interneIntérêt pour les pontages coronaires

Résumé Les caractéristiques anatomiques de l'a. radiale ont été comparées à celles de l'a. thoracique interne, cette dernière étant considérée comme le greffon de référence en chirurgie coronaire. La longueur, le diamètre, les branches collatérales et l'épaisseur pariétale de ces deux artères ont été étudiées. Une analyse histologique comparative a également été effectuée. Les caractéristiques anatomiques et histologiques de ces deux artères ont d'importantes implications pour la chirurgie de pontage coronaire.

     

Diet,commensal microbiota-derived extracellular vesicles,and host immunity

The gut microbiota has co-evolved with its host, and commensal bacteria can influence both the host's immune development and function. Recently, a role has emerged for bacterial extracellular vesicles (BEVs) as potent immune modulators. BEVs are nanosized membrane vesicles produced by all bacteria, possessing the membrane characteristics of the originating bacterium and carrying an internal cargo that may include nucleic acid, proteins, lipids, and metabolites. Thus, BEVs possess multiple avenues for regulating immune processes, and have been implicated in allergic, autoimmune, and metabolic diseases. BEVs are biodistributed locally in the gut, and also systemically, and thus have the potential to affect both the local and systemic immune responses. The production of gut microbiota-derived BEVs is regulated by host factors such as diet and antibiotic usage. Specifically, all aspects of nutrition, including macronutrients (protein, carbohydrates, and fat), micronutrients (vitamins and minerals), and food additives (the antimicrobial sodium benzoate), can regulate BEV production. This review summarizes current knowledge of the powerful links between nutrition, antibiotics, gut microbiota-derived BEV, and their effects on immunity and disease development. It highlights the potential of targeting or utilizing gut microbiota-derived BEV as a therapeutic intervention.     

MICROSURGICAL COMPOSITE TISSUE TRANSPLANTATION: A CLINICAL TRIAL

Twenty four patients suffering from various ailments necessitating flap cover were treated with composite tissue transplantation by microsurgical techniques from July 1992 to July 1996. There were 21 males and 3 females in the 10 to 50 years age group. Four patients were provided flap cover on the face for congenital lesions and twenty patients required flap cover for sub acute/chronic trauma. The radial artery forearm and latissimus dorsi were the most commonly used flaps in this study. Seventeen patients had excellent and four patients had acceptable cosmetic and functional results. Three flaps were lost due to vascular problems.KEYWORDS: Free flap, Cosmetic and functional results, Microsurgery, Tissue transplantation     

The role of Epstein-Barr virus in Hodgkin's disease from different geographical areas

Recent studies have suggested that Epstein-Barr virus (EBV) may play a role in the aetiology of Hodgkin's disease. To determine the role of EBV in childhood Hodgkin's disease in different geographical areas, immunohistochemical staining and in situ hybridisation were used to analyse latent membrane protein 1 (LMP 1) and small nuclear non-transcribed RNAs (EBER-1) respectively. Testing for EBV within the Reed-Sternberg and Hodgkin's cells was carried out in childhood Hodgkin's disease from 10 different countries. The proportion of LMP 1 positive cases varied significantly, being 50% of cases from the United Kingdom (38/75), South Africa (9/18), Egypt (7/14), and Jordan (8/16), 60% from the United Arab Emirates (6/10), 70% from Australia (11/16), 81% from Costa Rica (34/42), 88% from Iran (7/8), 90% from Greece (20/22), and 100% of the 56 cases from Kenya. A sensitive polymerase chain reaction based EBV strain typing technique was established using archival tissues. EBV strain type 1 was shown to be predominant in childhood Hodgkin's disease from the United Kingdom, South Africa, Australia, and Greece. Type 2 was predominant in Egypt. EBV strain types 1 and 2 were both detected in some cases of childhood Hodgkin's disease in the United Kingdom, Costa Rica, and Kenya. The high incidence of EBV and the presence especially in developing countries of dual infection with both strain types 1 and 2 may reflect socioeconomic conditions leading to malnutrition induced immunological impairment. The possibility of HIV infection also needs to be explored.     

Total energy expenditure and body composition in early infancy

In adults greater energy expenditure, primarily on physical activity, is associated with greater leanness. Such an association has proved more difficult to demonstrate in infants, partly due to the difficulty of measuring fatness and free living energy expenditure in this age group. Stable isotope techniques now make such investigations more viable. OBJECTIVE: The relationship between body composition and energy expenditure was investigated in 12 week infants. METHODS: Total energy expenditure and fat mass were estimated using the doubly labelled water technique. SUBJECTS: 92 normal healthy infants. RESULTS: Fat mass was correlated with both triceps and subscapular skinfold thicknesses (p < 0.001). After controlling for body size, age was a significant predictor of fat mass (p = 0.003), whereas total energy expenditure was not (p = 0.463). CONCLUSIONS: The cross sectional link between activity level and fatness in young infants, reported previously, does not persist when energy expenditure is considered.