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排序方式: 共有241条查询结果,搜索用时 15 毫秒
101.
102.
Andreas Hübel Sven Brandau Annette Dresel Joachim Clos 《Molecular and biochemical parasitology》1995,70(1-2):107-118
We have identified and isolated the Leishmania major homologue to the bacterial ClpB gene and to the yeast Hsp104 gene. ClpB in Leishmania major is a single-copy gene and encodes a low-abundance mRNA which is induced several-fold during a heat stress. We raised antibodies against the product of the recombinant gene and show that the leishmanial ClpB encodes a predominantly cytoplasmic protein of approx. 100 kDa which is detectable in Leishmania promastigotes of various species after exposure to elevated temperatures. We, therefore, term this protein Hsp100. 相似文献
103.
104.
Value of <Superscript>11</Superscript>C-choline PET and PET/CT in patients with suspected prostate cancer 总被引:2,自引:1,他引:1
Scher B Seitz M Albinger W Tiling R Scherr M Becker HC Souvatzogluou M Gildehaus FJ Wester HJ Dresel S 《European journal of nuclear medicine and molecular imaging》2007,34(1):45-53
Purpose: The value and limitations of 11C-choline PET and PET/CT for the detection of prostate cancer remain controversial. The aim of this study was to investigate
the diagnostic efficacy of 11C-choline PET and PET/CT in a large group of patients with suspected prostate cancer.
Methods: Fifty-eight patients with clinical suspicion of prostate cancer underwent 11C-choline PET (25/58, Siemens ECAT Exact HR+) or PET/CT (33/58, Philips Gemini) scanning. On average, 500 MBq of 11C-choline was administered intravenously. Studies were interpreted by raters blinded to clinical information and other diagnostic
procedures. Qualitative image analysis as well as semiquantitative SUV measurement was carried out. The reference standard
was histopathological examination of resection specimens or biopsy.
Results: Prevalence of prostate cancer in this selected patient population was 63.8% (37/58). 11C-choline PET and PET/CT showed a sensitivity of 86.5% (32/37) and a specificity of 61.9% (13/21) in the detection of the
primary malignancy. With regard to metastatic spread, PET showed a per-patient sensitivity of 81.8% (9/11) and produced no
false positive findings.
Conclusion: Based on our findings, differentiation between benign prostatic changes, such as benign prostatic hyperplasia or prostatitis,
and prostate cancer is feasible in the majority of cases when image interpretation is primarily based on qualitative characteristics.
SUVmax may serve as guidance. False positive findings may occur due to an overlap of 11C-choline uptake between benign and malignant processes. By providing functional information regarding both the primary malignancy
and its metastases, 11C-choline PET may prove to be a useful method for staging prostate cancer. 相似文献
105.
Meisenzahl EM Schmitt G Gründer G Dresel S Frodl T la Fougère C Scheuerecker J Schwarz M Boerner R Stauss J Hahn K Möller HJ 《Pharmacopsychiatry》2008,41(5):169-175
INTRODUCTION: Amisulpride appears to be an effective atypical agent for treating schizophrenia in a dose-dependent manner. METHODS: 29 patients suffering from schizophrenia or schizoaffective disorder were treated with a broad dose range of amisulpride (50-1 200 mg/day, mean: 455.2+/-278.8 mg/day). After 2 weeks, brain single photon emission tomography (SPET) scans were performed two hours after intravenous injection of 185 MBq [ (123)I]IBZM. Clinical evaluations and ratings of extrapyramidal symptoms were performed at baseline and after steady state treatment of two weeks with amisulpride. RESULTS: In patients treated with amisulpride, specific binding of [ (123)I]IBZM to D2 receptors was significantly decreased (p<0.001) compared to healthy controls. D2 receptor blockade correlated well with administered doses and plasma concentrations of amisulpride. Extrapyramidal side effects, which had to be treated with biperiden, were observed in 31% of the patients. Clinical response was very good, without correlation between the response and striatal D2 occupancy. DISCUSSION: Within the first two weeks of treatment with the atypical antipsychotic amisulpride a significant occupancy of striatal postsynaptic dopamine D2 receptors was achieved. At the same time amisulpride shows an excellent tolerability with good efficacy. 相似文献
106.
107.
Al-Kateb H Bähring S Hoffmann K Strauch K Busjahn A Nürnberg G Jouma M Bautz EK Dresel HA Luft FC 《Circulation research》2002,90(9):951-958
We studied a Syrian family with 3 children who had low-density lipoprotein cholesterol (LDL) concentrations of 13.3, 12.2, and 8.6 mmol/L, respectively. Three other siblings and the parents all had LDL values <4.52 mmol/L, suggesting an autosomal-recessive mode of inheritance. The extended pedigree had 66 additional persons with normal LDL values. A genome-wide scan in the core family with 427 markers showed support for linkage on both chromosomes 1 and 13. Markers on chromosome 1 revealed a 3.07 multipoint LOD score between 1p36.1-p35, an 18-cM interval. Surprisingly, we also found linkage to 13q22-q32, a 14-cM interval, with a 3.08 LOD score. We had identified this locus earlier as containing a gene strongly influencing LDL in another Arab family with autosomal-dominant familial hypercholesterolemia and in normal dizygotic twins. We found evidence for an interaction between these loci. We next genotyped our twin panel and confirmed linkage of the 1p36.1-p35 locus to LDL (P<0.002) in this normal population. Elucidation of ARH, the LDL receptor adaptor protein at chromosome 1p35, caused us to sequence that gene. We first identified the genomic structure of ARH gene and then sequenced the gene in our family. We found an intron 1 acceptor splice-site mutation. This mutation was not found in any other family members, in 31 nonrelated Syrian persons, or in 30 Germans. Our results underscore the importance of ARH on chromosome 1 and the chromosome 13q locus to LDL, not only in families with unusual illnesses, but also to the general population. 相似文献
108.
Klein Uhlmann Dresel Klose Clauberg H. Bernhardt Balthasar Rosenhagen 《Journal of molecular medicine (Berlin, Germany)》1944,23(21-26):244-247
109.
Dresel Oettel Sperling Mader Z. Dtsch Balthasar Klein Vogel Schübel Bernhardt W. Fischer Gerbis Pauschardt 《Journal of molecular medicine (Berlin, Germany)》1942,21(48):1064-1066
Ohne Zusammenfassung 相似文献
110.
Oettel Schübel Vaternahm Klose Mündel Dresel Dinkler A. Hermann Müller Wledermann 《Journal of molecular medicine (Berlin, Germany)》1942,21(41):912-914
Ohne Zusammenfassung 相似文献