针式腹腔镜下胆囊切除术的临床应用

目的 与开腹胆囊切除术相比,腹腔镜胆囊切除术（ＬＣ）有减少术后不适和较少的创作,但仍有改进的余地。方法：为进一步减轻手术创伤,我们引进了针式腹间胆囊切除术,共２９例。结果 平均手术时间为７５分钟,１９例当天出院,１０例隔天出院,其中１例是胆总管探查。结论 针式航空 镜胆囊切除术是一种可靠的技术。     

Orthodontisches Meß- und Simulationssystem (OMSS) für die statische und dynamische Analyse der Zahnbewegung

Zusammenfassung Es wird ein orthodontisches Meß- und Simulationssystem (OMSS) vorgestellt. Hauptbestandteile dieses Systems sind zwei Meßtische, die sich jeweils aus einem Kraft/Momenten-Sensor und einem motorisch angetriebenen, dreidimensional beweglichen Positioniertisch zusammensetzen. Die Kraft/Momenten-Aufnehmer sind in der Lage, die auf einen Zahn einwirkenden Kraftsysteme vollständig zu erfassen, da sie sowohl alle Kräfte als auch alle Drehmomente simultan messen können. Unter Verwendung des Computerprogramms OMSS, das auf einem Personal-Computer läuft, können eine Vielzahl verschiedener Messungen ausgeführt werden. Zum einen gestattet das System die Durchführung sogenannter Absolutmessungen, die im einfachsten Falle das Aufnehmen von Kraft/Weg-Diagrammen, bei komplizierten Fragestellungen auch die Erfassung mehrdimensionaler Kraft/Weg- oder Drehmoment/Weg-Kurven erlauben. Zum anderen werden Simulationen der Zahnbewegung unterstützt, bei denen, basierend auf dem auf einen Zahn einwirkenden Kraftsystem, die resultierenden Bewegungen errechnet und ausgeführt werden. Mit Hilfe des so realisierten Computertypodonten kann nicht nur das statische, sondern auch das dynamische Verhalten kieferorthopädischer Behandlungselemente untersucht werden. Die Einsatzmöglichkeiten des Systems werden anhand mehrerer Beispiele demonstriert.

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Summary An orthodontic measurement and simulation system (OMSS) is presented. The major components of this system are two measuring tables each comprising a force/torque sensor and a motor driven, fully three-dimensionally adjustable positioning stage. The force/torque sensors are capable of measuring simultaneously all forces and torques acting on a tooth. Using the computer programm OMSS which runs on a personal computer, several different measurements can be conducted. On the one hand, the system supports absolute measurements such as the registration of a force/deflection diagram. Furthermore, even multidimensional force/deflection-or torque/distance curves can be measured. On the other hand, simulations of orthodontic tooth movement can be conducted. In such simulations, the force system acting on a tooth is measured and the resulting tooth movements are calculated. By using this computer typodont, not only the static but the dynamic behaviour of orthodontic appliances can be studied. The application of this system is demonstrated by the analysis of several orthodontic problems.

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Herrn Professor Dr. Dr.G. P. F. Schmuth zum 65. Geburtstag.

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Diese Arbeit wurde gefördert durch die Deutsche Forschungsgemeinschaft (Dr 196/1 und Schm 232/2-1).     

Fludarabine: a new agent with major activity against chronic lymphocytic leukemia

Fludarabine was used to treat 68 patients with previously treated chronic lymphocytic leukemia (CLL). Nine (13%) patients achieved a complete remission and 30 (44%) a partial remission. The response rates for Rai stages 0 to 2, 3, and 4 were 64%, 58%, and 50% respectively. Seventeen (43%) of the 40 Rai stage 1 to 3 patients and four (19%) of the Rai stage 4 patients returned to Rai stage 0. Survival was strongly correlated with the final Rai stage achieved. The survival of the 11 partial responders with residual disease consisting only of residual bone-marrow nodules was similar to the complete responders (36+ months) and superior to the other partial response patients (16 months). The response to fludarabine was rapid, with 36 (92%) of the 39 responders having achieved at least a partial response following the first three courses. Complete responses occurred in the blood, liver, spleen, and lymph nodes in 48% to 69% of the patients. Eradication of all disease in the bone marrow occurred in only 13% of the cases. Neutropenia and thrombocytopenia occurred in 56% and 25% of evaluable courses. Major infections occurred in 9% of evaluable courses and fevers of unknown origin or minor infections in 12% of courses respectively. Myelosuppression and infection were more common in patients with initial Rai stages 3 and 4 and in nonresponding patients. Other toxicity was mild. No CNS toxicity was noted.     

A study of HLA (Bg) on red cells and platelets by immunoblotting with monoclonal antibodies

HLA class I antigens (Bg) on red cells (RBCs) are expressed by some normal donors and by many patients with systemic lupus erythematosus (SLE). To identify the membrane components previously detected by hemagglutination with HLA class I-specific monoclonal antibodies (MoAbs), RBC membrane preparations were separated by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and immunoblotted with the HLA class I MoAbs. Two components were obtained that reacted with the MoAbs: a heavy chain of 45 kDa and a light chain termed beta2-microglobulin (beta2-M) of 11 kDa. The effect of chloroquine and acid elution in stripping HLA antigens is shown to be due to the removal of beta2-M, as only that component was detected in eluates from reactive RBCs. Neither antibody elution method affected the heavy chain expression assessed by immunoblotting. It is concluded that HLA class I antigens on RBCs are integral membrane components of the type normally found and wisely distributed on many nucleated cells. Platelets, which have stronger HLA class I antigen expression, were also studied, and their membrane preparations yielded heavy chain and beta2-M molecules; the effect of chloroquine treatment was harder to assess than that of acid elution, owing to the sensitivity with which both components are detected in immunoblotting. In eluates obtained from acid treatment only beta2-M is detected.     

WHO生存质量评估简表的等价性评价

目的评价WHO生存质量评估简表(WHOQOL-BREF)在13个国家的等价性。方法采用多组验证性因子分析方法,对世界卫生组织生存质量研究小组提供的13个国家的数据进行分析,评价WHOQOL-BREF不同国家的等价性。结果各个国家的各个领域的Cronbachα系数均大于0·7,分布在0·7至0·88之间。除了英国和挪威之外,其它国家的社会关系领域的Cronbachα系数均大于0·65。采用根据世界卫生组织生存质量研究小组研制量表时构建的四因子模型对数据分别进行拟合,拟合优度指数(CFI)均大于0·8,其中德国、西班牙和美国的拟合优度指数大于0·9。多组验证性因子分析发现模型拟合尚可,CFI等于0·88,各个国家的因子负荷不全相等,因子负荷的轮廓相似。结论WHOQOL-BREF在13个国家具有相同的因子结构,且有等价性。     

Manubriosternal subluxation/dislocation can lead to manubriosternal septic arthritis in patients with kyphoscoliosis

Locally deranged joint anatomy can predispose to septic arthritis which can be managed by surgical debridement. We present a case of manubriosternal subluxation/dislocation caused by kyphoscoliosis leading to manubriosternal septic arthritis.