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41.
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BACKGROUND: Seizure frequency is in abnormal distribution, and it is not enough to express the trend of concentration using means, and its median loses a lot of information, thus it lacks of a standard for evaluating the therapeutic effects based on seizure frequency.
OBJECTIVE: To establish a method for evaluating the therapeutic effects on anti-epileptic drugs using changes of interval and duration of seizure.
DESIGN: A prospective cohort study.
SETTING: Zhumadian Psychiatric Hospital.
PARTICIPANTS: Outpatients and inpatients suffering from epilepsy attending firstly visited Zhumadian Psychiatric Hospital from June 2001 to June 2002 were enrolled. They were diagnosed as epileptic according to the International Classification of Epileptic Seizure by International League Against Epilepsy (1981) based on the clinical history, physical examination, and investigations. The interval time was no more than 6 months. Informed consent was obtained from all the subjects, and the study was approved by the hospital ethical committee.
METHODS: ① For the first visit and each follow-up, the following data were recorded, including general demographic information, seizure type, the date and time of ictus, the duration of ictus, and inducement or situation related, according to which the following indexes could be calculated, including seizure styles, interval, duration, cluster frequency and cluster duration. The information from the first review was noted as annals A. The second interview was taken at the end of the evaluating period; the information from the second review was noted as annals B. The third interview was taken within two weeks after the second one; the information from the third review was noted as annals C. The annals B or the annals C were respectively compared with the annals A in the light of the same types or the same styles of the same patient. Summation of the scores of interval change and duration change of the same type or the same style and 5 of basic score was the score of a corresponding seizure type or a corresponding style of one patient. In order to test its reliability and validity, the score of change of frequency or duration plus 5 scores respectively was the score of frequency or duration. ② Reliability and validity were tested by calculating corresponding correlation coefficient with SPSS 11.0. ROC curve was used for developing diagnostic criterion of predicting therapeutic effects with SPSS 11.0.
MAIN OUTCOME MEASURES: ① Reliability and validity; ② Diagnostic criterion for predicting therapeutic effects one year later.
RESULTS: Totally 28 patients were involved in the final analysis of results. ① Reliability and validity were high: rinter-rater=0.98, rtest-retest=0.99, rconstruct validity=0.83. ② A total score > 6 was the optimal diagnostic criteria for predicting therapeutic effects one year later, in other words, a patient who scored more than 6 at the evaluating period may be seizure-free one year later.
CONCLUSION: It is a potential tool for evaluating epileptic therapeutic outcome, and it can be diffusely used in interrelated fields after being further validated. 相似文献
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In 75 patients with subacute fulminant hepatitis B (SAFH), HDAg positive liver cells were observed in 14 cases (18.67%) by direct enzyme labelled method. It was found further that HDV (delta factor) infection was an important cause in producing massive necrosis of liver cells and superinfection of HDV with hepatitis B was identified as one of the causes of SAFH. This experiment also showed that the number of HDAg positive cells was in direct proportion to the area of liver necrosis. No obvious lymphocytic infiltrations and cytotoxic phenomena around the necrotic foci and HDAg positive cells could be found, while the cytoplasmic type HDAg positive cells showed distinct degeneration or even atrophy. Hence it was suggested that HDV could be a direct pathogenesis. No obvious characteristic changes in morphology of HDV infection could be found.
相似文献
45.
电针改善硬膜外吗啡用于术后镇痛所引起的免疫抑制 总被引:1,自引:1,他引:0
为观察硬膜外吗啡和电针对术后患者免疫功能的影响,检测自然杀伤细胞(NKcell)活性和PHA诱导白细胞介素2(IL-2)水平在单纯胆囊切除术患者术前和术后第1、3、7天的动态变化情况。结果吗啡组NK活性在术后第1、3、7天抑制,手术组仅在术后第1、3天出现抑制,而抑制率低于同天的吗啡组,电针可拮抗吗啡引起的NK活性抑制加深状况。在术后第1天,手术组和吗啡组IL-2水平均下降,吗啡+电针组无明显变化,术后第7天吗啡+电针组IL-2升高接近正常人水平。表明电针能改善硬膜外吗啡引起的免疫抑制,促进术后机体的恢复。硬膜外吗啡结合电针是值得推荐的术后镇痛方法。 相似文献
46.
目的:探讨联合应用成纤维细胞介导IL2和IL3的基因疗法对骨髓移植(BMT)后荷瘤小鼠抗肿瘤作用的效果及机理。方法:将分别转染IL2基因及IL3基因的NIH3T3细胞以单独或联合方式移植至BMT的荷瘤小鼠腹腔内8d后,取出小鼠骨髓细胞检测杀伤活性的变化以及IL2受体的表达,并观察荷瘤小鼠的存活期。结果:IL3基因治疗虽然可加速BMT后造血重建过程,但对骨髓细胞的NK、LAK活性具有一定的抑制作用;IL2基因治疗可明显提高骨髓细胞的杀伤活性;联合应用基因治疗后荷瘤小鼠骨髓NK、LAK活性及骨髓细胞CD25表达升高,明显延长大剂量化疗后接受BMT的荷瘤小鼠的存活期。结论:联合应用IL2和IL3的基因疗法能协同提高骨髓细胞IL2受体表达水平,提高骨髓细胞毒活性,增强BMT后的抗肿瘤效果。 相似文献
47.
In order to clarify the reasons for the reduced Hb A2 levels in Sardinian delta beta-thalassemia, we characterized, both by cloning and sequence analysis and by direct sequencing of amplified DNA, the delta-globin gene from an individual of Sardinian descent who is a compound heterozygote for the beta zero-thalassemia codon 39 (C-->T) nonsense mutation and the Sardinian delta beta-thalassemia [codon 39(C-->T)/-196(C-->T)A gamma]. The analysis of the delta-globin gene from the delta beta-thalassemia chromosome revealed an entirely normal sequence. The defective function of the delta-globin gene in this determinant is thus likely related to a suppressive effect of the in cis nondeletional high persistence of fetal hemoglobin mutation of the A gamma gene, probably resulting from an increased capability of the relative promoter to interact with the locus control region. 相似文献
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聚合酶链反应(PCR)对单纯疱疹病毒性脑炎的临床诊断价值 总被引:2,自引:1,他引:1
应用聚合酶链反应(PCR)检测技术对118例颅内感染性疾病患者及37例无神神经系统疾病患者脑脊液(CSF)中的单纯疱疹病毒DNA(HSV-DNA)进行了检测及分型。结果提示:“散发性脑炎”组的阳性率为38.46%(20/52),细菌、真菌性脑膜炎、其它病毒性脑炎组以及无神经系统疾病组均为阴性。作者认为:①本检测是目前单纯疹病毒性脑炎(HSE)较为简便而准确的早期诊断方法之一;②HSV分型检测,对病原诊断更具有全面性;③两型单纯疱疹病毒均可引起HSE。 相似文献
50.
大狼毒三萜类化学成分的研究 总被引:3,自引:0,他引:3
自大戟科(Euphorbiaceae)植物大狼毒(Euphorbia nematocypha Hand—Mazz)根的乙醇提取物的苯溶解部分,经20%AgNO3硅胶层析,分离得到七个三萜类成分。根据光谱(IR,EIMS,1H—NMR和13C—NMR)和化学方法,确定其中一个化合物为新化合物,命名为大狼毒醇(nematocyphol,Ⅳa),其它化合物为已知物:印度荆芥醇乙酸酯(nepehinol acetate Ⅰ),日尔曼醇乙酸酯(germanicol acetate Ⅱ),大戟醇(euphol,Ⅲ),蒲公英醇(taraxasterol,Ⅴa),24-亚甲基环阿尔廷醇(24-methylenecycloartanol,Ⅴa)和印度荆芥醇(nepehinol,Ⅶa)。这些化合物均为首次从大狼毒中得到。 相似文献