全文获取类型
收费全文 | 175665篇 |
免费 | 12290篇 |
国内免费 | 4474篇 |
专业分类
耳鼻咽喉 | 2388篇 |
儿科学 | 2508篇 |
妇产科学 | 2271篇 |
基础医学 | 25698篇 |
口腔科学 | 3872篇 |
临床医学 | 18017篇 |
内科学 | 30025篇 |
皮肤病学 | 4426篇 |
神经病学 | 12864篇 |
特种医学 | 9323篇 |
外国民族医学 | 19篇 |
外科学 | 21812篇 |
综合类 | 9405篇 |
现状与发展 | 17篇 |
一般理论 | 31篇 |
预防医学 | 10078篇 |
眼科学 | 4348篇 |
药学 | 16663篇 |
51篇 | |
中国医学 | 4220篇 |
肿瘤学 | 14393篇 |
出版年
2024年 | 234篇 |
2023年 | 1618篇 |
2022年 | 4531篇 |
2021年 | 6806篇 |
2020年 | 3974篇 |
2019年 | 4516篇 |
2018年 | 5334篇 |
2017年 | 4523篇 |
2016年 | 5412篇 |
2015年 | 7676篇 |
2014年 | 9152篇 |
2013年 | 10126篇 |
2012年 | 15065篇 |
2011年 | 14889篇 |
2010年 | 9159篇 |
2009年 | 7597篇 |
2008年 | 10342篇 |
2007年 | 9976篇 |
2006年 | 9029篇 |
2005年 | 8516篇 |
2004年 | 7041篇 |
2003年 | 6481篇 |
2002年 | 5531篇 |
2001年 | 4312篇 |
2000年 | 3775篇 |
1999年 | 3081篇 |
1998年 | 1468篇 |
1997年 | 1214篇 |
1996年 | 871篇 |
1995年 | 876篇 |
1994年 | 693篇 |
1993年 | 517篇 |
1992年 | 1018篇 |
1991年 | 890篇 |
1990年 | 806篇 |
1989年 | 725篇 |
1988年 | 582篇 |
1987年 | 592篇 |
1986年 | 451篇 |
1985年 | 430篇 |
1984年 | 301篇 |
1983年 | 212篇 |
1982年 | 157篇 |
1981年 | 185篇 |
1980年 | 143篇 |
1979年 | 236篇 |
1978年 | 167篇 |
1976年 | 138篇 |
1974年 | 147篇 |
1973年 | 132篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
目的探讨脑卒中患者急性应激障碍发生现状及影响因素。方法采用斯坦福急性应激反应问卷对349例脑卒中住院患者进行调查。结果共163例(46.70%)患者发生急性应激障碍;Logistic回归分析结果显示,患者性格、是否存在偏瘫及是否吞咽功能障碍是脑卒中患者发生急性应激障碍的主要影响因素(P0.05,P0.01)。结论脑卒中患者急性应激障碍发生率较高,内向性格及存在偏瘫和吞咽功能障碍的患者更容易发生急性应激障碍。医护人员应及时为高危患者提供个体化治疗及预见性护理,防止脑卒中患者发生急性应激障碍。 相似文献
12.
13.
Hyun Jong Choi Jong Ho Moon Yun Nah Lee Hyun Su Kim Ji Su Ha Tae Hoon Lee Sang‐Woo Cha Young Deok Cho Sang‐Heum Park 《Digestive endoscopy》2015,27(7):772-775
Direct peroral cholangioscopy (POC) using an ultra‐slim upper endoscope is one modality of POC for intraductal endoscopic evaluation and treatment of the bile duct. Choledochoduodenostomy (CDS) is one modality of biliary bypass surgery that provides a new route to the bile duct. We carried out direct POC using an ultra‐slim upper endoscope without the use of accessories in 10 patients (four sump syndromes, three bile duct strictures and three intrahepatic duct stones) previously undergoing surgical CDS. Direct POC was successful in all patients. The use of an intraductal balloon catheter was required in one patient for advancement of the endoscope into the bile duct. Distal bile ducts with sump syndromes were cleared using baskets and water irrigation under direct POC. Cholangiocarcinoma was diagnosed in one patient with hilar bile duct stricture after cholangioscopic evaluation and a targeting forceps biopsy under direct POC. Intrahepatic duct stones were successfully extracted after intraductal fragmentation under direct POC. Oozing bleeding occurred during intraductal lithotripsy but stopped spontaneously. Direct POC using an ultra‐slim upper endoscope without the assistance of accessories can easily be carried out in patients undergoing CDS. 相似文献
14.
15.
16.
17.
Jae Yun Ahn Jung Bae Park Sungbae Moon Jae Wan Cho Dong Ho Park 《Ophthalmic epidemiology》2020,27(2):105-114
ABSTRACT
Purpose
Work-related eye injuries have been reported with a variety of epidemiologic and clinical characteristics. We aimed to identify epidemiologic characteristics of work-related eye injuries and risk factors associated with severe injury in a large metropolitan city. 相似文献18.
【摘要】 报道临床症状不典型的家族性黑棘皮病1家系。先证者女,4岁,自1周岁时,颈部、腹部出现黑色斑片,近年来逐渐扩大至唇周、躯干前部。腹部皮肤全反式共聚焦显微镜检查可见乳头环下延扭曲及沟壑结构,乳头环内可见中高折光颗粒结构。先证者父亲及祖母既往有类似病史,但随着年龄增长色素沉着自发性消退,仅有局部皮纹增粗。采集先证者及父母、祖母外周血,对先证者外周血DNA行Panel靶向测序,结果显示,先证者存在FGFR3基因14号外显子c.1949A>C(p.Lys650Thr)错义突变,Sanger测序验证证实先证者及其父亲和祖母均存在此突变。诊断:家族性黑棘皮病。 相似文献
19.
20.
Can EGFR mutation status be reliably determined in pre‐operative needle biopsies from adenocarcinomas of the lung?
下载免费PDF全文
![点击此处可从《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Kim Hein Lindahl Flemming Brandt Sørensen Søren Peter Jonstrup Karen Ege Olsen Siegfried Loeschke 《APMIS : acta pathologica, microbiologica, et immunologica Scandinavica》2015,123(4):289-297
The identification of EGFR mutations in non‐small‐cell lung cancer is important for selecting patients, who may benefit from treatment with EGFR tyrosine kinase inhibitors. The analysis is usually performed on cytological aspirates and/or histological needle biopsies, representing a small fraction of the tumour volume. The aim of the present investigation was to evaluate the diagnostic performance of this molecular test. We retrospectively included 201 patients with primary adenocarcinoma of the lung. EGFR mutation status (exon 19 deletions and exon 21 L858R point mutation) was evaluated on both pre‐operative biopsies (131 histological and 70 cytological) and on the surgical specimens, using PCR. Samples with low tumour cell fraction were assigned to laser micro‐dissection (LMD). We found nine (4.5%) patients with EGFR mutation in the lung tumour resections, but failed to identify mutation in one of the corresponding pre‐operative, cytological specimens. Several (18.4%) analyses of the pre‐operative biopsies were inconclusive, especially in case of biopsies undergoing LMD and regarding exon 21 analysis. Discrepancy of mutation status in one patient may reflect intra‐tumoural heterogeneity or technical issues. Moreover, several inconclusive results in the diagnostic biopsies reveal that attention must be paid on the suitability of pre‐operative biopsies for EGFR mutation analysis. 相似文献