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991.
Wendum D Prevot S Poujol-Robert A Rosmorduc O Cabane J Fouillard L Flejou JF 《Gastroentérologie clinique et biologique》2004,28(1):80-83
Systemic mastocytosis is a disease defined by an abnormal infiltration of mast cells involving several extra-cutaneous organs. Hepatic involvement is frequent, however it rarely reveals the disease. We report two cases of systemic mastocytosis revealed by hepatic symptoms: liver failure in one case and jaundice in the second case. The diagnosis is often difficult. Mast cell tissular infiltration can be identified on paraffin sections by tryptase or CD117 (c-kit) immuno-staining. 相似文献
992.
Fischer DC de Amorim Gualda NC Bachiega D Carvalho CS Lupo FN Bonotto SV Alves Mde O Yogi A Santi SM Avila PE Kirchgatter K Moreno PR 《Acta tropica》2004,92(3):261-266
In the search for new antimalarial agents, nine Brazilian plant species were selected, from the Annonaceae (6), Menispermaceae (2) and Siparunaceae (1) families naturally occurring at the cerrado and Atlantic rainforest regions, in order to investigate their in vitro antiplasmodial activity. The ethanol and the alkaloid extracts were tested against K1, chloroquine-resistant, and Palo Alto, chloroquine-sensitive, strains of Plasmodium falciparum. The majority of the alkaloid extracts were more active than the ethanol ones, with IC(50) ranging 0.3-8.2 microg/mL. The crude Guatteria australis alkaloids were the most active against K1 with an IC(50) = 0.3 microg/mL. The most promising total alkaloid fractions for further bioguided isolation are those with the IC(50) < or = 5 microg/mL: G. australis, Cissampelos ovalifolia and Duguetia lanceolata. 相似文献
993.
994.
Vandooren B Kruithof E Yu DT Rihl M Gu J De Rycke L Van Den Bosch F Veys EM De Keyser F Baeten D 《Arthritis and rheumatism》2004,50(9):2942-2953
995.
James M Hutchinson David M Patrick Fawziah Marra Helen Ng William R Bowie Laurie Heule Mark Muscat Dominique L Monnet 《The Canadian Journal of Infectious Diseases & Medical Microbiology》2004,15(1):29-35
Despite the global public health importance of resistance of microorganisms to the effects of antibiotics, and the direct relationship of consumption to resistance, little information is available concerning levels of consumption in Canadian hospitals and out-patient settings. The present paper provides practical advice on the use of administrative pharmacy data to address this need. Focus is made on the use of the Anatomical Therapeutic Chemical classification and Defined Daily Dose system. Examples of consumption data from Canadian community and hospital settings, with comparisons to international data, are used to incite interest and to propose uses of this information. It is hoped that all persons responsible for policy decisions regarding licensing, reimbursement, prescribing guidelines, formulary controls or any other structure pertaining to antimicrobial use become conversant with the concepts of population antibiotic consumption and that this paper provides them with the impetus and direction to begin accurately measuring and comparing antibiotic use in their jurisdictions.Key Words: Antibacterial agents, Drug utilization, Pharmacoepidemiology 相似文献
996.
Guggisberg D Hadj-Rabia S Viney C Bodemer C Brunelle F Zerah M Pierre-Kahn A de Prost Y Hamel-Teillac D 《Archives of dermatology》2004,140(9):1109-1115
OBJECTIVES: To verify the diagnostic value of lumbosacral midline cutaneous lesions in asymptomatic children to detect occult spinal dysraphism (OSD) and to propose a practical approach for clinical investigations with respect to the type of cutaneous lesions observed. DESIGN: Retrospective study of 54 children referred to the Department of Pediatric Dermatology between 1990 and 1999 for congenital midline lumbosacral cutaneous lesions. SETTING: The private or institutional practices of participating dermatologists and pediatricians. MAIN OUTCOME MEASURES: Evaluation of the diagnostic value of midline cutaneous lesions for the detec-tion of OSD. Association of skin examination findings with spinal anomalies detected by magnetic resonance imaging or ultrasound. RESULTS: Occult spinal dysraphism was detected in 3 of 36 patients with an isolated congenital midline lesion and 11 of 18 patients with a combination of 2 or more different skin lesions. CONCLUSIONS: A combination of 2 or more congenital midline skin lesions is the strongest marker of OSD. Careful dermatologic examination is needed to detect suggestive markers and request a spinal magnetic resonance image, which is the most sensitive radiologic approach to detect an OSD. 相似文献
997.
998.
999.
Abnormality of vergence latency in
children with vertigo 总被引:4,自引:0,他引:4
Bucci MP Kapoula Z Yang Q Wiener-Vacher S Brémond-Gignac D 《Journal of neurology》2004,251(2):204-213
Abstract. It is well known that vergence movements are important for
distance appreciation, depth vision and stereopsis. Moreover,
vergence movements are very probably used by the CNS during head
and body motion to adjust the gain of the vestibulo-ocular
reflex (VOR) according to the viewing distance. A recent
clinical study of Anoh-Tanon et al. suggested that vertigo in
children with normal vestibular function could be associated
with abnormal vergence clinically assessed. The purpose of this
study was to test this hypothesis with objective vergence eye
movement recordings. We examined the latency of vergence,
saccades and combined movements in twelve children with the
complaint of vertigo but without vestibular abnormality.
Convergence and saccades combined with convergence or with
divergence had abnormally long latencies (relative to normal
children of matched age). In contrast, divergence and isolated
saccades showed only mild latency increase relative to normals.
Lengthening of latency could be due to impaired cortical
control. Orthoptic vergence training reduced all latencies;
however, even the reduced latency of vergence and of combined
movements was still abnormal. The improvement after orthoptic
vergence training could be due to increased visual attention,
although such mechanism cannot eliminate completely the
initiation deficit of vergence movements. Objective eye movement
recordings are thus useful for a diagnosis and treatment of
children with vertigo. 相似文献
1000.
BACKGROUND: Secondary prevention measures in patients with cerebral ischemia or coronary heart disease (CHD) consist of vascular risk factors management and antithrombotic therapy. The aim of this study was to compare how secondary prevention measures are applied in practice between patients with a history of CHD or cerebral ischemia. METHOD: We compared vascular risk factors management and antithrombotic therapy between patients with a history of CHD and patients with a history of cerebral ischemia that occurred 2 months to 6 years earlier. Whether patients were properly treated or not was determined by a comparison between their current treatments and European guidelines for stroke and CHD management. RESULTS: We included 107 consecutive patients with a history of cerebral ischemia and 85 consecutive patients with a history of CHD. We found that: (i). most patients did not receive an appropriate secondary prevention in both groups: 76 of 107 patients with previous cerebral ischemia (71 %) and 73 of 85 patients with CHD (85.9 %); (ii). identification of risk factors, such as hypercholesterolemia, diabetes mellitus and smoking, did not differ between both groups, but arterial hypertension was more frequent in CHD patients; (iii). an inappropriate management of risk factors was more frequent in patients with TIA vs. ischemic stroke, and angina pectoris vs. myocardial infarction; (iv). arterial hypertension and hypercholesterolemia were the 2 more frequent risk factors that were not properly treated; (v). more than half diabetic patients had hyperglycemia > or= 126 mg/dl in both groups; (vi). patients with previous CHD had twice more frequently stopped smoking than those with cerebral ischemia. CONCLUSION: Many patients were not properly treated in both groups, and differences between practice and guidelines were more frequent in the CHD group, where guidelines are more strict. 相似文献