Resorption of untreated metastases after subjection of rabbit brown-pearce tumors to high-intensity ultrasonic waves

Summary The action of high-intensity ultrasonic waves leads to disintegration of Brown-Pearce tumors inoculated into rabbits a week or more previously. In addition, the untreated metastases have been shown in many instances to undergo similar regression. Just as with the primary, treated nodule, they become replaced by scar tissue, defifferentiate and encapsulate or resorb tracelessly.This must mean that the intense ultrasonic vaves act not only on the primary tumor directly, but also, must produce basic alterations in the animal organism as a whole which enable it to check the developing cancer everywhere in the body.This fundamental problem must become the subject of special investigations.Presented by Active Member Acad. Sci. USSR A. D. Timoffevsky     

Hyperlipidemia, hypercoagulability, and accelerated thrombosis: studies in congenitally hyperlipidemic rats and in rats and monkeys with induced hyperlipidemia

Inbred Carworth Farms Nelson (CFN) congenitally hyperlipidemic rats had significantly shorter coagulation and prothrombin times and higher levels of coagulation factors, II, V, VII, VIII, and X than did controls. Conversely, congenitally hypolipidemic rats of the same strain had significantly longer coagulation and prothrombin times and lower levels of factors II, V, VII, X and XII and of blood platelets than did controls. A loop-shaped polyethylene cannula was inserted into the aorta to assess the potential for thrombosis. The hyperlipidemic group obstructed this significantly faster and the hypolipidemic group slower than did the controls. Normal CFN rats made hypertensive by unilateral renal artery clip developed hypertension together with significantly elevated serum cholesterol and factor VII and X levels. Rhesus monkeys with diet-induced hyperlipidemia showed shorter prothrombin times and higher factor X levels than did controls on normal diet. By selective breeding, two groups of squirrel monkeys were obtained. Both groups had similar serum cholesterol levels on a normal diet but one group (hyperresponders) showed higher serum cholesterol levels on a cholesterol-containing diet than did the other (hyporesponder) group. Both groups showed significantly elevated levels of factors II, V, VII, IX and X on a cholesterol-containing diet. There was good correlation between the levels of many coagulation factors and serum cholesterol in both rats and monkeys. If thrombosis is important in the genesis of atherosclerosis, these findings could indicate that elevation of plasma lipids may play a role, via the coagulation pathway, in the production of human vascular disease.