Greater trochanteric overgrowth: development and surgical correction

Greater trochanteric advancement (GTA) is an orthopedic procedure designed to correct the biomechanical consequences of overgrowth of the greater trochanter by moving the greater trochanter and its attached muscles laterally and distally. Thirty-one children with trochanteric overgrowth who had secondary pelvic instability (Trendelenburg sign) were studied and underwent a total of 33 GTA procedures. The clinical and radiologic prerequisites for successful surgery are presented. In addition, the radiographic methods of measuring the lateral position of the trochanter, the articulotrochanteric distance, and the amount of trochanteric overgrowth are discussed. Measurements made on preoperative and postoperative radiographs revealed that surgery achieved a mean displacement laterally of 12.1 mm and distally 21 mm. Clinically, there were few complications (two children with mild myositis, one with broken hardware, one with delayed union of trochanter). Pelvic instability had disappeared in the 25 of the 30 patients who could be evaluated.     

线性系统理论预报槐果碱在大鼠体内处置动力学

用线性系统理论和生理药代动力学模型理论结合,提出一种预报槐果碱在大鼠各组织中处置动力学的数学方法,并用实验验证该方法的可靠性。结果表明数学模拟值与实验观察值基本吻合。扩展到2.5kg兔,iv 25 mg后和2.5mg/min滴注过程中血药浓度预示值与观察值基本一致。