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41.
42.
G. Galloro M. Mignogna C. de Werra L. Magno G. Diamantis E. Ruoppo P. Iovino 《Digestive and liver disease》2005,37(3):195-199
BACKGROUND AND AIMS: The involvement of oesophagus in pemphigus vulgaris is still debated. The aims of this study were to evaluate the prevalence of oesophageal involvement and the gastro-duodenal mucosa appearance before and after high-dose corticosteroid therapy in a group of patients with oral pemphigus vulgaris. METHODS: We prospectively studied 28 consecutive patients with oral pemphigus by oesophageal symptom standardised questionnaire, upper gastro-intestinal endoscopy, exfoliative cytology and histological biopsy. After clinical remission, all patients underwent new endoscopy. RESULTS: The prevalence of oesophageal symptoms was 57.1%. Endoscopic examination revealed oesophageal involvement with different degrees of severity in 67.8% of patients. After corticosteroid therapy, endoscopy showed normal oesophageal-gastro-duodenal mucosa. No examination-related exacerbations of the oesophageal lesions were seen. CONCLUSIONS: The upper gastro-intestinal endoscopic examination, in oral pemphigus vulgaris patients with oesophageal symptoms, is safe in skilled hands technique and a useful diagnostic tool prior to starting therapy. 相似文献
43.
Matti Karvanen Diamantis Plachouras Lena E. Friberg Elisabeth Paramythiotou Evangelos Papadomichelakis Ilias Karaiskos Iraklis Tsangaris Apostolos Armaganidis Otto Cars Helen Giamarellou 《Antimicrobial agents and chemotherapy》2013,57(1):668-671
This report describes the pharmacokinetics of colistin methanesulfonate (CMS) and colistin in five intensive care unit patients receiving continuous venovenous hemodiafiltration. For CMS, the mean maximum concentration of drug in plasma (Cmax) after the fourth dose was 6.92 mg/liter and total clearance (CL) 8.23 liters/h. For colistin, the mean concentration was 0.92 mg/liter and CL/metabolized fraction (fm) 18.91 liters/h. Colistin concentrations were below the current MIC breakpoints, and the area under the concentration-time curve for the free, unbound fraction of the drug over 24 h in the steady state divided by the MIC (fAUC/MIC) was lower than recommended, suggesting that a dosage regimen of 160 mg CMS every 8 h (q8h) is inadequate. 相似文献
44.
Lazaros T Sichletidis Diamantis Chloros Ioannis Tsiotsios Ioannis Kottakis Ourania Kaiafa Stella Kaouri Alexandros Karamanlidis Dimitrios Kalkanis Sotirios Posporelis 《Primary care respiratory journal》2006,15(2):92-97
AIM: To investigate the prevalence of smoking in the general population and in specific population sub-groups in Northern Greece. METHODS: A cross-sectional study was conducted during the period 1999-2001 on a 5% sample (23,840) of those people aged between 21 to 80 out of a total general population of 653,249. 21,854/23,840 general population subjects were interviewed. In addition, we interviewed 9,276 high school students, 1,072 medical students, 597 medical doctors within the National Health System, 825 teachers, and 624 subjects who regularly exercised in a privately-owned gym. A specially modified ICRF study group questionnaire was used. RESULTS: 34.4% of the general population sample were current smokers (47.8% of males and 21.6% of females). Smoking prevalence rates in the population sub-groups were: 29.6% of high school students; 40.7% of medical students; 44.9% of medical doctors; 46.4% of teachers; and 36.9% of the gym group. CONCLUSION: The prevalence of smoking in Northern Greece is high. High school and medical students present with high smoking rates, and the same situation is observed in medical doctors and teachers. An intensification of preventive antismoking measures is required. 相似文献
45.
Andreas Sfakianakis Konstantin Krasagakis Maria Stefanidou Sofia Maraki Anastassios Koutsopoulos Diamantis Kofteridis George Samonis Androniki Tosca 《Medical mycology》2007,45(1):81-84
A rare case of an invasive cutaneous infection by Geotrichum candidum in an 80-year-old male patient with diabetes mellitus is reported. The primary site of infection manifested after trauma as an ulcerative lesion on the distal phalanx of the midfinger and extended throughout the right hand. Histological examination showed fungal invasion in the deep dermis without vascular involvement and G. candidum was grown in cultures from the biopsy material. Angiography revealed severe obstructive disease of the right brachial artery and its branches. Treatment, after susceptibility testing of the isolated strain, consisted of sequential administration of intravenous liposomal amphotericin B with oral voriconazole followed by liposomal amphotericin B, resulting in substantial improvement of the infection. 相似文献
46.
47.
F Munier S Uffer C P Herbort E Perentes I Diamantis P Othenin-Girard P A Grounauer H P Rutz J Biollaz 《Klinische Monatsbl?tter für Augenheilkunde》1992,200(5):550-554
We report the case of a 25-year-old black female from Zaire with AIDS diagnosed 2 years earlier. Nine months before her death, she was treated for a disseminated Kaposi sarcoma with vincristin, adryamycin and bleomycin. At that time, visual acuity was normal and ophthalmologic examination was unremarkable except for the presence of bilateral Drusen and a cotton wool spot OS. Three months after the onset of chemotherapy, the patient complained of progressive visual field constriction, which progressed to blindness within a 4 month period. Five months after the onset of the tri-therapy a bilateral CMV retinitis developed, which was successfully treated by intravitreous injections of ganciclovir. This therapy was stopped as soon as blindness was established, with subsequent massive bilateral recurrence of the CMV retinitis. Histologic examination showed complete atrophy of the retinal ganglion cells and areas of CMV retinitis. The optic nerve was demyelinated and exhibited astrocytic gliosis. Immunohistochemistry confirmed the presence of CMV in infected retina and revealed the absence in the optic nerve of the class III beta-tubulin isotype and of the 200 kd neurofilament subunit. In contrast, oculomotor nerves appeared intact. The presence of HIV in the eye and in the optic nerve was excluded using PCR technique. The retinal ganglion cell loss and optic nerve atrophy appeared to be purely degenerative in nature, since there was no evidence of vascular occlusion, inflammation or retrobulbar compressive process. We therefore conclude that blindness was caused by vincristine therapy. The patient actually received 22 mg of vincristin intravenously in 11 courses over 7 months, although discontinuation was recommended by us after 5 months.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
48.
Inhibition of allergic and non-allergic histamine secretion from rat peritoneal mast cells by calcium antagonists. 下载免费PDF全文
Bepridil, TMB-8 (8-(diethylamino)octyl 3,4,5-trimethoxybenzoate hydrochloride), diltiazem, verapamil and nifedipine exerted concentration-dependent inhibition of antigen and calcium ionophore A23187-induced histamine release from rat peritoneal mast cells. The inhibitory effects of verapamil and bepridil against calcium ionophore A23187-induced histamine secretion were antagonized by increased Ca2+ concentrations in the extracellular medium. These observations suggest that both agents act by interfering with the influx of Ca2+ into the mast cells. The inhibitory activities of five different Ca2+ channel blockers on allergic and non-allergic histamine secretion from rat peritoneal mast cells varied considerably depending upon the nature of the secretagogue as well as concentration and type of Ca2+-antagonist examined. 相似文献
49.
Induction of non-specific airway hyperreactivity by potassium channel blockade in rat isolated trachea. 总被引:1,自引:1,他引:0 下载免费PDF全文
1. The exposure of rat isolated tracheal segment to the K(+)-channel inhibitor tetraethylammonium (TEA, 10 mM) for a period of 10-15 min generally produced little or no contractile response. 2. Cooling (10 C) provocation alone usually produced small (10 +/- 3% acetylcholine maximum) contractile responses. 3. In the presence of TEA (10 mM, 10-15 min exposure), rat trachea exhibited airway hyperreactivity to acetylcholine, 5-hydroxytryptamine (5-HT) and cooling. It also increased the peak tension induced by 5-HT. 4. TEA-induced airway hyperreactivity to cooling was significantly inhibited in Ca2(+)-free Krebs solution suggesting an important role for extracellular Ca2+ influx. 5. We conclude that the blockade of potassium channels with TEA induces non-specific airway hyperreactivity to cooling, 5-HT and acetylcholine in rat isolated tracheal segments. 相似文献
50.
R D Sofia W Diamantis R Gordon M Kletzkin F M Berger J Edelson H Singer J F Douglas 《European journal of pharmacology》1974,26(1):51-62
W-2395, a new heterocyclic compound, is an orally effective anti-inflammatory, analgesic and antipyretic agent. It is active in adjuvant-induced polyarthritis when given prophylactically or therapeutically. W-2395 also inhibits carrageenan-induced hind paw edema in the rat, an activity which is not altered by adrenalectomy or hypophysectomy. The analgesic activity of W-2395 is superior to that of acetylsalicylic acid or phenylbutazone, while its antipyretic activity in rats with yeast-induced fever is equivalent to aspirin. Unlike other useful anti-inflammatory agents, W-2395 does not produce ulcers when given in effective doses, nor does it cause gastrointestinal blood loss as measured by the excretion of 51Cr-tagged red blood cells. However, at lethal doses ulcerogenicity was observed. W-2395 has a weak diuretic effect which most likely does not contribute to its anti-inflammatory action. 相似文献