全文获取类型
收费全文 | 1316452篇 |
免费 | 101848篇 |
国内免费 | 2898篇 |
专业分类
耳鼻咽喉 | 18747篇 |
儿科学 | 45285篇 |
妇产科学 | 36008篇 |
基础医学 | 186388篇 |
口腔科学 | 34335篇 |
临床医学 | 114817篇 |
内科学 | 267342篇 |
皮肤病学 | 28633篇 |
神经病学 | 103807篇 |
特种医学 | 52661篇 |
外国民族医学 | 662篇 |
外科学 | 201463篇 |
综合类 | 29117篇 |
现状与发展 | 2篇 |
一般理论 | 378篇 |
预防医学 | 97860篇 |
眼科学 | 28461篇 |
药学 | 98157篇 |
10篇 | |
中国医学 | 3371篇 |
肿瘤学 | 73694篇 |
出版年
2019年 | 10123篇 |
2018年 | 14276篇 |
2017年 | 10906篇 |
2016年 | 11899篇 |
2015年 | 13657篇 |
2014年 | 18829篇 |
2013年 | 28207篇 |
2012年 | 38660篇 |
2011年 | 40693篇 |
2010年 | 24383篇 |
2009年 | 23277篇 |
2008年 | 38825篇 |
2007年 | 41418篇 |
2006年 | 41483篇 |
2005年 | 40327篇 |
2004年 | 39273篇 |
2003年 | 37873篇 |
2002年 | 37081篇 |
2001年 | 64942篇 |
2000年 | 67388篇 |
1999年 | 57263篇 |
1998年 | 15486篇 |
1997年 | 14030篇 |
1996年 | 14467篇 |
1995年 | 13669篇 |
1994年 | 12969篇 |
1993年 | 11955篇 |
1992年 | 44971篇 |
1991年 | 43842篇 |
1990年 | 42588篇 |
1989年 | 40495篇 |
1988年 | 37201篇 |
1987年 | 36525篇 |
1986年 | 33893篇 |
1985年 | 32485篇 |
1984年 | 24323篇 |
1983年 | 20413篇 |
1982年 | 11809篇 |
1981年 | 10762篇 |
1979年 | 21495篇 |
1978年 | 14919篇 |
1977年 | 12615篇 |
1976年 | 11749篇 |
1975年 | 12682篇 |
1974年 | 14754篇 |
1973年 | 14227篇 |
1972年 | 13044篇 |
1971年 | 11823篇 |
1970年 | 11125篇 |
1969年 | 10102篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
111.
112.
To determine the protective effect of aloe-emodin (AE) from high glucose induced toxicity in RIN-5F (pancreatic β-cell) cell and restoration of its function was analyzed. RIN-5F cells have been cultured in high glucose (25 mM glucose) condition, with and without AE treatment. RIN-5F cells cultured in high glucose decreased cell viability and increased ROS levels after 48 hr compared with standard medium (5.5 mM glucose). Glucotoxicity was confirmed by significantly increased ROS production, increased pro-inflammatory (IFN-γ, IL-1β,) & decreased anti-inflammatory (IL-6&IL-10) cytokine levels, increased DNA fragmentation. In addition, we found increased Bax, caspase 3, Fadd, and Fas and significantly reduced Bcl-2 expression after 48 hr. RIN-5F treated with both high glucose and AE (20 μM) decreased ROS generation and prevent RIN-5F cell from glucotoxicity. In addition, AE treated cells cultured in high glucose were transferred to standard medium, normal responsiveness to glucose was restored within 8hr and normal basal insulin release within 24 hr was achieved when compared to high glucose. 相似文献
113.
114.
115.
116.
117.
118.
119.
F. Murina R. Felice S. Di Francesco L. Nelvastellio I. Cetin 《Gynecological endocrinology》2020,36(5):431-435
AbstractThis study is a single-center, retrospective analysis of postmenopausal women presenting with dyspareunia and vulvar pain, aiming to evaluate relative effectiveness of vestibular CO2 laser therapy as a treatment. Three monthly sessions of laser were performed to each patient and thereafter a three-months follow-up was stablished. A total number of 72 patients undergoing vestibular laser treatment were recruited from patient files in the period between 2016 and 2018. Among these, 39 women also received a concomitant treatment with ospemifene (60?mg/day) during the study period. There was a statistically significant reduction of all the symptoms in both groups up to the three month follow-up. Regarding dryness and dyspareunia, the relief tent to be more prominent in the ospemifene?+?laser group at all follow-ups and remained statistically significant at three-month follow-up. Specifically, vestibular dryness was significantly lower in the ospemifene?+?laser group compared with the laser treatment group (?87% vs???34%, respectively), and the vestibular health score started declining faster in the ospemifene?+?laser group. Although, additional research is needed to understand the mechanism of action, our data shows that a combination regimen of laser and ospemifene may improve clinical effectiveness for long-term treatment of symptoms associated with the under-recognized genitourinary syndrome of menopause. 相似文献
120.
目的 初步探讨应用艾尔巴韦/格拉瑞韦治疗慢性丙型肝炎(CHC)患者的疗效。方法 2017年3月~2018年3月仙桃市第一人民医院感染病科收治的CHC患者82例,被随机分为对照组41例和观察组41例,分别给予聚乙二醇干扰素-α联合利巴韦林治疗和艾尔巴韦/格拉瑞韦治疗,两组均连续治疗24周。采用RT- PCR法检测血清 HCV RNA,采用全基因序列测定法行病毒基因分型。比较两组早期病毒学应答(EVR)、治疗结束时病毒学应答(ETVR)和持续病毒学应答(SVR)。结果 在治疗结束时,观察组血清丙氨酸氨基转移酶(ALT)水平为(47.9±19.7)U/L,显著低于对照组【(63.5±21.2)U/L,P<0.05】,天冬氨酸氨基转移酶(AST)水平为(55.5±22.3)U/L,显著低于对照组【(81.3±25.8)U/L,P<0.05】;观察组EVR、ETVR和SVR分别为48.8%、63.4%和70.7%,与对照组的41.5%、53.7%和65.8%比,无统计学差异(P>0.05);18例观察组非HCV Ⅰ型感染者EVR、ETVR和SVR分别为88.9%、94.4%和88.9%,显著高于同组23例HCV Ⅰ型感染者(分别为52.2%、60.9%和52.2%, P<0.05),而与对照组15例非HCV Ⅰ型感染者比,无统计学差异(分别为86.7%、93.3%和73.3%, P>0.05);观察组SVR12为87.8%(36/41),显著高于对照组的73.2%(30/41,P<0.05)。结论 应用直接抗病毒(DAA)药物艾尔巴韦/格拉瑞韦治疗CHC患者近期疗效达到,但远期疗效似优于标准治疗方案, 值得临床进一步验证。 相似文献