全文获取类型
收费全文 | 2516篇 |
免费 | 207篇 |
国内免费 | 7篇 |
专业分类
耳鼻咽喉 | 3篇 |
儿科学 | 60篇 |
妇产科学 | 35篇 |
基础医学 | 484篇 |
口腔科学 | 32篇 |
临床医学 | 291篇 |
内科学 | 584篇 |
皮肤病学 | 69篇 |
神经病学 | 244篇 |
特种医学 | 74篇 |
外科学 | 266篇 |
综合类 | 7篇 |
一般理论 | 1篇 |
预防医学 | 141篇 |
眼科学 | 29篇 |
药学 | 161篇 |
中国医学 | 5篇 |
肿瘤学 | 244篇 |
出版年
2023年 | 29篇 |
2022年 | 43篇 |
2021年 | 97篇 |
2020年 | 55篇 |
2019年 | 92篇 |
2018年 | 99篇 |
2017年 | 62篇 |
2016年 | 74篇 |
2015年 | 77篇 |
2014年 | 128篇 |
2013年 | 136篇 |
2012年 | 246篇 |
2011年 | 241篇 |
2010年 | 137篇 |
2009年 | 114篇 |
2008年 | 163篇 |
2007年 | 180篇 |
2006年 | 169篇 |
2005年 | 147篇 |
2004年 | 138篇 |
2003年 | 99篇 |
2002年 | 80篇 |
2001年 | 11篇 |
2000年 | 7篇 |
1999年 | 9篇 |
1998年 | 27篇 |
1997年 | 6篇 |
1996年 | 5篇 |
1995年 | 4篇 |
1993年 | 3篇 |
1992年 | 3篇 |
1990年 | 4篇 |
1989年 | 2篇 |
1988年 | 4篇 |
1986年 | 2篇 |
1984年 | 4篇 |
1980年 | 2篇 |
1976年 | 3篇 |
1974年 | 2篇 |
1972年 | 2篇 |
1971年 | 2篇 |
1969年 | 2篇 |
1967年 | 2篇 |
1964年 | 2篇 |
1960年 | 1篇 |
1911年 | 1篇 |
1903年 | 1篇 |
1899年 | 2篇 |
1898年 | 2篇 |
1896年 | 1篇 |
排序方式: 共有2730条查询结果,搜索用时 15 毫秒
71.
72.
73.
74.
75.
Flavien Rouxel Raissa Relator Jennifer Kerkhof Haley McConkey Michael Levy Patricia Dias Mouna Barat-Houari Nathalie Bednarek Odile Boute Nicolas Chatron Florian Cherik Andrée Delahaye-Duriez Martine Doco-Fenzy Laurence Faivre Lucas W. Gauthier Delphine Heron Michael S. Hildebrand Gaëtan Lesca David Genevieve 《Genetics in medicine》2022,24(5):1096-1107
PurposeRare genetic variants in CDK13 are responsible for CDK13-related disorder (CDK13-RD), with main clinical features being developmental delay or intellectual disability, facial features, behavioral problems, congenital heart defect, and seizures. In this paper, we report 18 novel individuals with CDK13-RD and provide characterization of genome-wide DNA methylation.MethodsWe obtained clinical phenotype and neuropsychological data for 18 and 10 individuals, respectively, and compared this series with the literature. We also compared peripheral blood DNA methylation profiles in individuals with CDK13-RD, controls, and other neurodevelopmental disorders episignatures. Finally, we developed a support vector machine–based classifier distinguishing CDK13-RD and non–CDK13-RD samples.ResultsWe reported health and developmental parameters, clinical data, and neuropsychological profile of individuals with CDK13-RD. Genome-wide differential methylation analysis revealed a global hypomethylated profile in individuals with CDK13-RD in a highly sensitive and specific model that could aid in reclassifying variants of uncertain significance.ConclusionWe describe the novel features such as anxiety disorder, cryptorchidism, and disrupted sleep in CDK13-RD. We define a CDK13-RD DNA methylation episignature as a diagnostic tool and a defining functional feature of the evolving clinical presentation of this disorder. We also show overlap of the CDK13 DNA methylation profile in an individual with a functionally and clinically related CCNK-related disorder. 相似文献
76.
77.
78.
79.
80.
Magali Dewaele Delphine Truffier-Boutry Jacques Devaux Ga?tane Leloup 《Dental materials》2006,22(4):359-365
Polymerization shrinkage and degree of conversion (DC) of resin composites are closely related manifestations of the same process. Ideal dental composite would show an optimal degree of conversion and minimal polymerization shrinkage. These seem to be antagonistic goals, as increased monomer conversion invariably leads to high polymerization shrinkage values. OBJECTIVES: This paper aims at accurately determining the polymerization volume contraction of experimental neat resins and to link it to the number of actual vinyl double bonds converted in single ones instead of, as generally done, to the degree of conversion. METHODS: Different mixtures of Bis-GMA/TEGDMA (traditionally used monomers) were analyzed. Contraction of the polymers was determined by pycnometry and the use of a density column. DC was determined by the use of Raman spectrometry. RESULTS: An univocal relationship has been found between the volume contraction and the actual number of vinyl double bonds converted into single ones. A contraction value of 20.39 cm3/mole (of converted C=C) was deduced from 27 measurements. SIGNIFICANCE: This relationship helps in finding solutions to the polymerization shrinkage problem. A reduction of the polymerization shrinkage due to the chemical reaction may obviously be expected from the addition of molecules allowing a decrease in the number of double bonds converted per unit volume of resin matrix, while maintaining the degree of conversion (of Bis-GMA and TEGDMA) and thus the mechanical properties. Further research will be directed at this objective. 相似文献