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41.
Ivana Pavlinac Ana Marin Maja Valić Jelena Marušić Damir Roje Renata Pecotić Ivica Tadin Zoran Ðogaš 《Central European Journal of Medicine》2008,3(2):187-193
To investigate the influence of the wars in Croatia and Bosnia and Herzegovina on incidence and perinatal outcome of singleton
preterm births at the Department of Gynecology and Obstetrics in the Split University Hospital. Data were collected by reviewing
patients’ files at the Department of Gynecology and Obstetrics from three periods: the three years before the war (1988–1990),
during the war (1992–1994), and after the war (1996–1998). A total of 2,358 patients’ files of singleton preterm delivery
were analyzed. Singleton preterm delivery rate decreased during the war (5.02%) and post-war period (4.74%) compared to the
pre-war period (6.19%). Stillbirth and early neonatal mortality rates of singleton premature babies significantly increased
during the war to 226%, compared to 193% before the war and 134% after the war. Early neonatal mortality rate was 215% during
the war, 209% in the pre-war period, and 156% after the war. Despite the continuous decrease in singleton preterm birth rate
throughout the observed periods, the increase in stillbirth rate and early neonatal mortality rate during the war might have
been caused by the war. This may be due to primary gynecological care being inadequate for many pregnant women. 相似文献
42.
Damir Kosutic Vedran Uglesic Predrag Knezevic Aleksandar Milenovic Miso Virag 《Journal of plastic, reconstructive & aesthetic surgery》2008,61(6):620-627
A total of 21 patients with latissimus dorsi-scapula free flap reconstruction immediately following radical maxillectomy together with orbital exenteration are presented. Orbital exenteration was performed in all patients due to tumour invasion at the time of diagnosis. There was no total flap failure. Two tissue components subdivided into separate flap units with individual vascular pedicles linked by a single vascular source provide an ideal reconstructive solution for massive defects of the mid-face and orbit. Separate arcs of rotation of each flap unit permit greater mobility necessary for complex three-dimensional reconstruction. A vertically positioned angle of the scapula enables simultaneous reconstruction of the malar eminence and alveolar ridge whereas spontaneous intraoral epithelialisation of the latissimus dorsi muscle requires no additional procedure. For these reasons, in our opinion, combined latissimus dorsi-scapula free flap should be considered the first choice in reconstruction of defects following total maxillectomy with orbital exenteration. 相似文献
43.
The effects of diet-induced changes in blood acid-base status on mineral retention has been studied in lambs fed diets containing either 1% NH4Cl or 2% NaHCO3. Balance measurements using 45Ca and 32P showed no difference between them in the amounts of dietary Ca and P absorbed from the gut. Retention of both minerals, however, was lower and their excretion in urine higher in those fed the acid diet. Plasma Ca and P levels were unaffected but parathyroid hormone and 1,25-dihydroxyvitamin D3 levels were higher in lambs on this diet while measurements of tartrate-resistant acid phosphatase and alkaline phosphatase levels in rib samples indicated an increase in osteoclast and a reduction in osteoblast activity in these lambs. Cell-mediated changes in bone turnover together with changes in urinary mineral loss would thus appear to be the major factors contributing to the lower rates of mineral retention seen in lambs fed acid diets. 相似文献
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46.
Cellular uptake and efflux of azithromycin, erythromycin, clarithromycin, telithromycin, and cethromycin 下载免费PDF全文
Bosnar M Kelnerić Z Munić V Eraković V Parnham MJ 《Antimicrobial agents and chemotherapy》2005,49(6):2372-2377
Macrolide antibiotics have an outstanding ability to concentrate within host cells, particularly phagocytes. In the study described in this paper five different macrolide antibiotics were compared regarding the uptake and release kinetics in human peripheral blood polymorphonuclear neutrophils (PMNs) and three different cell lines, two phagocytic cell lines (RAW 264.7 and THP-1) and an epithelial cell line (MDCK). Based on the results obtained, the substances tested could be clustered into different groups. Azithromycin constituted the first group, characterized by rapid and nonsaturable uptake into phagocytic cells and a high degree of retention in the preloaded cells. The second group included erythromycin and clarithromycin. These two substances do not exhibit cell specificity; consequently, they are taken up to a similar extent and are released by all cell types studied. Ketolides constituted the last group. Their uptake was saturable in cells of monocytic lineage as well as in nondifferentiated cells of myeloid lineage, and they were rapidly released from all the cell lines studied. However, in PMNs, ketolide uptake was not saturable; and unlike telithromycin, cethromycin rapidly egressed from the loaded cells. 相似文献
47.
48.
Damir D Munteanu F 《Revista medico-chirurgical?? a Societ????ii de Medici ??i Naturali??ti din Ia??i》2010,114(4):1240-1245
The main aim of this study is to present the use of bone substitutes in chronic ostheomielitis surgical treatment and its biomechanical influence. MATERIAL AND METHODS: First step is three-dimensional reconstruction to one femur using CT sections; the second is the reconstruction of infected bone volume, synthesis of material properties, synthesis of loading forces, synthesis of boundary condition and, finally, finite element analysis. RESULTS: The calculated Von Mises stress as a result of finite element analysis indicates that bone substitute implantation lead to a stress distribution in bone similar with a health femur. 相似文献
49.
Modest DP Reinacher-Schick A Stintzing S Giessen C Tannapfel A Laubender RP Brodowicz T Knittelfelder R Vrbanec D Schmiegel W Heinemann V Zielinski CC 《Anti-cancer drugs》2012,23(6):666-673
KRAS p.G13D mutant metastatic colorectal cancer (mCRC) has been identified as representing a cetuximab-sensitive subtype of KRAS mutant mCRC. This analysis aims to answer the question of whether first-line treatment of p.G13D mCRCs should include cetuximab or bevacizumab. Fifty-four patients with p.G13D mutant mCRC were pooled in this analysis. All patients underwent systemic first-line treatment with a fluoropyrimidine and oxaliplatin/irinotecan that was combined with either cetuximab or bevacizumab. The analysis of cetuximab-based and bevacizumab-based regimens in mCRC patients with p.G13D-mutated tumours indicated comparable data for the overall response rate (58 vs. 57%) and progression-free survival (8.0 vs. 8.7 months; hazard ratio: 0.96, P=0.9). Overall survival (OS) was 20.1 months in patients treated with cetuximab-based first-line therapy compared with 14.9 months in patients receiving bevacizumab-containing regimens (hazard ratio: 0.70, P=0.29). Logistic regressions modelling OS revealed oxaliplatin-based first-line treatment to correlate with a poor outcome (P=0.03). Moreover, a strong trend in favour of capecitabine compared with infusional 5-FU (P=0.06) was observed. Response to treatment correlated with OS in patients receiving cetuximab-based, but not bevacizumab-based regimens. This retrospective pooled analysis suggests comparable efficacy of cetuximab-based and bevacizumab-based first-line therapy in patients with p.G13D mutant mCRC. The combination with capecitabine and irinotecan was associated with a more favourable outcome compared with infusional 5-FU and oxaliplatin. 相似文献
50.
Physicians occasionally encounter the punch-drunk syndrome among boxers after longlasting careers characterized by blows to the head. The list of sports leading to punch-drunk syndrome is rapidly increasing, making it a notable public health problem. A lack of specific findings leads to defects in reporting the condition, and consequently to delay in treatment. Although the rigorous enforcement of sport rules and constant improvements of sporting equipment have decreased the occurrence of the syndrome, early detection of punch-drunk syndrome is crucial and would have comprehensive benefits. Two groups of signs and symptoms can be identified: dementia and Parkinsonism. A prompt diagnosis with a correct classification of the suspected cases is crucial. Therefore, we offer an overview of the symptomatology as well as proposing the introduction of a screening method among risk groups based on generic and minute neurological examination and dementia testing. 相似文献