全文获取类型
收费全文 | 2625篇 |
免费 | 322篇 |
国内免费 | 15篇 |
专业分类
耳鼻咽喉 | 7篇 |
儿科学 | 122篇 |
妇产科学 | 57篇 |
基础医学 | 243篇 |
口腔科学 | 9篇 |
临床医学 | 270篇 |
内科学 | 986篇 |
皮肤病学 | 75篇 |
神经病学 | 290篇 |
特种医学 | 29篇 |
外科学 | 278篇 |
综合类 | 58篇 |
预防医学 | 232篇 |
眼科学 | 36篇 |
药学 | 138篇 |
中国医学 | 6篇 |
肿瘤学 | 126篇 |
出版年
2024年 | 8篇 |
2023年 | 67篇 |
2022年 | 21篇 |
2021年 | 66篇 |
2020年 | 66篇 |
2019年 | 30篇 |
2018年 | 133篇 |
2017年 | 123篇 |
2016年 | 116篇 |
2015年 | 93篇 |
2014年 | 100篇 |
2013年 | 115篇 |
2012年 | 240篇 |
2011年 | 297篇 |
2010年 | 73篇 |
2009年 | 96篇 |
2008年 | 205篇 |
2007年 | 198篇 |
2006年 | 139篇 |
2005年 | 155篇 |
2004年 | 176篇 |
2003年 | 126篇 |
2002年 | 111篇 |
2001年 | 55篇 |
2000年 | 30篇 |
1999年 | 17篇 |
1998年 | 33篇 |
1997年 | 13篇 |
1996年 | 9篇 |
1995年 | 9篇 |
1994年 | 8篇 |
1993年 | 3篇 |
1992年 | 6篇 |
1991年 | 2篇 |
1990年 | 1篇 |
1989年 | 1篇 |
1988年 | 1篇 |
1987年 | 3篇 |
1986年 | 9篇 |
1985年 | 2篇 |
1983年 | 1篇 |
1981年 | 2篇 |
1980年 | 1篇 |
1979年 | 1篇 |
1977年 | 1篇 |
排序方式: 共有2962条查询结果,搜索用时 15 毫秒
81.
82.
83.
84.
85.
86.
Background
A therapeutic strategy for symptomatic patients with chronic gastritis has not been established. Gastric acid has been reported to induce a variety of unpleasant abdominal symptoms. We investigated whether the histamine H2 receptor antagonist famotidine attenuated upper abdominal symptoms in patients with chronic gastritis.Methods
In this multicenter prospective single-arm open-label study, 10,311 patients with a clinical diagnosis of chronic symptomatic gastritis were enrolled and each patient was administered famotidine at 20 mg/day for 4 weeks. The intensity levels of upper abdominal symptoms, epigastralgia, epigastric fullness, and heartburn were evaluated using a face scale (grade 0–4). Abdominal symptom-related quality of life (QOL) impairment was also evaluated, using an Izumo scale before and after famotidine administration. In a subgroup analysis, symptomatic responses in patients diagnosed with functional dyspepsia (FD) according to the Rome III criteria were analyzed.Results
In 8,460 patients who completed the protocol, famotidine administration significantly attenuated epigastralgia, epigastric fullness, and heartburn, and famotidine also attenuated abdominal symptom-related QOL impairment in all patients with chronic symptomatic gastritis, in those with FD-like symptoms without organic disease, and in those with FD as defined by the Rome III criteria.Conclusion
Famotidine is effective to relieve abdominal symptoms and improve QOL, not only in patients with Rome III-defined FD, but also in those with chronic symptomatic gastritis.87.
Guedj H Guedj J Negro F Lagging M Westin J Bochud PY Bibert S Neumann AU;DITTO-HCV study group 《Journal of viral hepatitis》2012,19(7):488-496
Hepatitis C viral (HCV) kinetics after initiation of interferon-based therapy provide valuable insights for understanding virus pathogenesis, evaluating treatment antiviral effectiveness and predicting treatment outcome. Adverse effects of liver fibrosis and steatosis on sustained virological response have been frequently reported, yet their impacts on the early viral kinetics remain unclear. In this study, associations between histology status and early viral kinetics were assessed in 149 HCV genotype 1-infected patients treated with pegylated interferon alfa-2a and ribavirin (DITTO trial). In multivariate analyses adjusted for critical factors such as IL28B genotype and baseline viral load, presence of significant fibrosis (Ishak stage > 2) was found to independently reduce the odds of achieving an initial reduction (calculated from day 0 to day 4) in HCV RNA of ≥2 logIU/mL (adjusted OR 0.03, P = 0.004) but was not associated with the second-phase slope of viral decline (calculated from day 8 to day 29). On the contrary, presence of liver steatosis was an independent risk factor for not having a rapid second-phase slope, that is, ≥0.3 logIU/mL/week (adjusted OR 0.22, P = 0.012) but was not associated with the first-phase decline. Viral kinetic modelling theory suggests that significant fibrosis primarily impairs the treatment antiviral effectiveness in blocking viral production by infected cells, whereas the presence of steatosis is associated with a lower net loss of infected cells. Further studies will be necessary to identify the biological mechanisms underlain by these findings. 相似文献
88.
89.
90.
Ingrid B. de Groot J. Iraida E. Veen Paul J. M. van der Boog Sandra van Dijk Anne M. Stiggelbout Perla J. Marang‐van de Mheen The PARTNER‐study group 《Clinical transplantation》2013,27(4):E415-E423
Purpose of this study was to assess whether living (LD) and deceased donor (DD) kidney transplant recipients differ in health‐related quality of life (HRQoL), fatigue and societal participation, depending on time since transplantation and after adjustment for clinical and demographic variables. A questionnaire study was performed among 309 LD and 226 DD recipients (response rate 74% and 61%) transplanted between 1997 and 2009. After adjustment for age, sex, and education, LD recipients transplanted less than or equal to five yr ago experienced better HRQoL than DD recipients on the domains' role limitations due to physical problems, general health perception, and on the physical component summary score (all p < 0.05) and a better societal participation (all subscales, p < 0.05). No differences were found in the mental health domains. The LD recipients also had better renal clearance than DD recipients (62.1 vs. 55.9 mL/min, p = 0.01). After additional adjustment for renal clearance, the differences in HRQoL and societal participation between LD and DD recipients remained. No differences were found in recipients transplanted more than five yr ago. We conclude that LD recipients on average have better HRQoL and societal participation than DD recipients, in the first years after transplantation. 相似文献