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Jing Ying Lim Roslee Rajikan Noh Amit Nazlena Mohamad Ali Haslina Abdul Hamid Huey Yin Leong Maslina Mohamad Bi Qi Koh Aini Musa 《Nutrients》2022,14(12)
Dietary intervention is generally accepted as the mainstay of treatment for patients with disorders of amino acid metabolism (AAMDs). However, dietary adherence to a low-protein diet is always reported as a common challenge among these patients. This study explored the perception of barriers and motivators to dietary adherence among caregivers of AAMD patients in Malaysia. Twenty caregivers of children with AAMDs receiving ongoing treatment at the genetic clinic participated in an online focus group discussion from November to December 2021. Findings showed a total of five interrelated main themes identified from focus group discussion (FGD) exploring parents’ experiences related to the management of their child’s daily diet. The barriers to dietary adherence were burden of dietary treatment, diet and dietary behavior, parenting challenges, limited knowledge related to dietary treatment, and challenges in healthcare system delivery. Key factors facilitating good dietary adherence include good knowledge of dietary treatment, parental coping strategies, social coping, and dietary behavior. In conclusion, despite the existence of several barriers to the implementation of dietary treatment, caregivers managed to use a wide range of coping strategies to overcome some, if not all, of the challenges. The important next step is to develop, in conjunction with multidisciplinary healthcare professionals, feasible implementation strategies that could address these barriers and at the same time improve the quality of life of caregivers. 相似文献
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Intraspinal primitive neuroectodermal tumor arising from the sacral spinal nerve root 总被引:2,自引:0,他引:2
H M Liu W C Yang R L Garcia J M Noh V Malhotra N E Leeds 《The Journal of computed tomography》1987,11(4):350-354
An unusual case of intraspinal primitive neuroectodermal tumor arising from the sacral spinal nerve root is presented with the first documentation of myelographic, computed tomographic, and magnetic resonance imaging findings. 相似文献
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Histone deacetylase (HDAC) inhibitors are currently being tested as anticancer agents in clinical trials. Chromatin remodeling, such as through histone acetylation, is a fundamental phenomenon in eukaryotic cell biology, bearing implications to numerous physiological and pathological phenomena. Here, we discuss recent data from our own laboratory and those of others demonstrating antifibrotic and renoprotective effect of HDAC inhibitors in diabetic kidneys, and the possible mechanisms including the role of reactive oxygen species. HDAC inhibitors may prove to be a novel class of multitarget agents in the treatment of diabetic nephropathy. 相似文献
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Ling Li Wenjun Wang Yu Pan Yuhan Zhu Xiaoguang Liu Hyeon Mi Noh Byung Kee Moon Byung Chun Choi Jung Hyun Jeong 《RSC advances》2018,8(3):1191
The vanadate-based phosphors Sr2V2O7:Eu3+ (SV:Eu3+), Sr9Gd(VO4)7:Eu3+ (SGV:Eu3+) and Sr9Gd(VO4)7/Sr2V2O7:Eu3+ (SGV/SV:Eu3+) were obtained by solid-state reaction. The bond-energy method was used to investigate the site occupancy preference of Eu3+ based on the bond valence model. By comparing the change of bond energy when the Eu3+ ions are incorporated into the different Sr, V or Gd sites, we observed that Eu3+ doped in SV, SGV or SV/SGV would preferentially occupy the smaller energy variation sites, i.e., Sr4, Gd and Gd sites, respectively. The crystal structures of SGV and SV, the photoluminescence properties of SGV:Eu3+, SV, SGV/SV and SGV/SV:Eu, as well as their possible energy transfer mechanisms are proposed. Interesting tunable colours (including warm-white emission) of SGV/SV:Eu3+ can be obtained through changing the concentration of Eu3+ or changing the relative quantities of SGV to SV by increasing the calcination temperature. Its excitation bands consist of two types of O2− → V5+ charge transfer (CT) bands with the peaks at about 325 and 350 nm respectively, as well as f–f transitions of Eu3+. The obtained warm-white emission consists of a broad photoluminescence band centred at about 530 nm, which originates from the O2− → V5+ CT of SV, and a sharp characteristic spectrum (5D0–7F2) at about 615 and 621 nm.The vanadate-based phosphors Sr2V2O7:Eu3+ (SV:Eu3+), Sr9Gd(VO4)7:Eu3+ (SGV:Eu3+) and Sr9Gd(VO4)7/Sr2V2O7:Eu3+ (SGV/SV:Eu3+) were obtained by solid-state reaction. 相似文献
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So-Youn Kwon Ok-Nam Bae Ji-Yoon Noh Keunyoung Kim Seojin Kang Young-Jun Shin Kyung-Min Lim Jin-Ho Chung 《Environmental health perspectives》2015,123(2):120-127
Background: Nephrotoxicity associated with lead poisoning has been frequently reported in epidemiological studies, but the underlying mechanisms have not been fully described.Objectives: We examined the role of erythrocytes, one of the major lead reservoirs, in lead-associated nephrotoxicity.Methods and results: Co-incubation of lead-exposed human erythrocytes with HK-2 human renal proximal tubular cells resulted in renal tubular cytotoxicity, suggesting a role of erythrocytes in lead-induced nephrotoxicity. Morphological and flow cytometric analyses revealed that HK-2 cells actively phagocytized lead-exposed erythrocytes, which was associated with phosphatidylserine (PS) externalization on the erythrocyte membrane and generation of PS-bearing microvesicles. Increased oxidative stress and up-regulation of nephrotoxic biomarkers, such as NGAL, were observed in HK-2 cells undergoing erythrophagocytosis. Moreover, TGF-β, a marker of fibrosis, was also significantly up-regulated. We examined the significance of erythrophagocytosis in lead-induced nephrotoxicity in rats exposed to lead via drinking water for 12 weeks. We observed iron deposition and generation of oxidative stress in renal tissues of lead-exposed rats, as well as the histopathological alterations such as tubulointerstitial lesions, fibrosis, and up-regulation of KIM-1, NGAL, and TGF-β.Conclusions: Our data strongly suggest that erythrophagocytosis and subsequent iron deposition in renal tubular cells could significantly enhance nephrotoxicity following lead exposure, providing insight on lead-associated kidney damages.Citation: Kwon SY, Bae ON, Noh JY, Kim K, Kang S, Shin YJ, Lim KM, Chung JH. 2015. Erythrophagocytosis of lead-exposed erythrocytes by renal tubular cells: possible role in lead-induced nephrotoxicity. Environ Health Perspect 123:120–127; http://dx.doi.org/10.1289/ehp.1408094 相似文献
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Jin-Won Noh Young Dae Kwon Sieun Yu Hyunchun Park Jong-Min Woo 《Yebang Ŭihakhoe chi》2015,48(1):62-71