全文获取类型
收费全文 | 24412篇 |
免费 | 1404篇 |
国内免费 | 135篇 |
专业分类
耳鼻咽喉 | 249篇 |
儿科学 | 625篇 |
妇产科学 | 502篇 |
基础医学 | 3667篇 |
口腔科学 | 1043篇 |
临床医学 | 2176篇 |
内科学 | 5662篇 |
皮肤病学 | 669篇 |
神经病学 | 2133篇 |
特种医学 | 564篇 |
外科学 | 2203篇 |
综合类 | 50篇 |
一般理论 | 10篇 |
预防医学 | 2333篇 |
眼科学 | 477篇 |
药学 | 1645篇 |
中国医学 | 112篇 |
肿瘤学 | 1831篇 |
出版年
2024年 | 33篇 |
2023年 | 255篇 |
2022年 | 602篇 |
2021年 | 1023篇 |
2020年 | 611篇 |
2019年 | 818篇 |
2018年 | 929篇 |
2017年 | 643篇 |
2016年 | 769篇 |
2015年 | 837篇 |
2014年 | 1108篇 |
2013年 | 1403篇 |
2012年 | 2191篇 |
2011年 | 2287篇 |
2010年 | 1198篇 |
2009年 | 985篇 |
2008年 | 1685篇 |
2007年 | 1624篇 |
2006年 | 1477篇 |
2005年 | 1368篇 |
2004年 | 1187篇 |
2003年 | 1000篇 |
2002年 | 880篇 |
2001年 | 96篇 |
2000年 | 63篇 |
1999年 | 86篇 |
1998年 | 124篇 |
1997年 | 106篇 |
1996年 | 86篇 |
1995年 | 65篇 |
1994年 | 56篇 |
1993年 | 57篇 |
1992年 | 39篇 |
1991年 | 34篇 |
1990年 | 27篇 |
1989年 | 29篇 |
1988年 | 22篇 |
1987年 | 11篇 |
1986年 | 22篇 |
1985年 | 18篇 |
1984年 | 27篇 |
1983年 | 14篇 |
1982年 | 16篇 |
1981年 | 10篇 |
1980年 | 3篇 |
1979年 | 6篇 |
1978年 | 5篇 |
1977年 | 5篇 |
1975年 | 2篇 |
1974年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
201.
Laura Tarjuelo Jos Emilio Pardo Manuel lvarez-Ortí Arturo Pardo-Gimnez Cristina Milln Adrin Rabadn 《Nutrients》2022,14(15)
A growing number of consumers now consider the consumption of processed meat products to be an essentially unhealthy habit. Hence, the reformulation of meat products is crucial. In this regard, the aim of this study is to reformulate “fuet”, a traditional Spanish dried sausage, by replacing the pork fat with emulsified seed oils (50–50%, 25–75% and 0–100%). Four seed oils were evaluated, including commercial seeds (poppy and chia) and other seeds considered subproducts (melon and pumpkin). Physical parameters, nutritional quality and consumer evaluation of the reformulated dried sausages were analyzed. Additionally, we considered the effects of food neophobia on consumer evaluation. The resulting fuets had a higher concentration of linoleic and linolenic acids, which varied according to the oil used. In the sensory analysis, non-neophobic consumers showed higher preference for the reformulated fuets, while all consumers gave their highest ratings to the fuets produced with pumpkin seed oil. 相似文献
202.
Alexandra Mataleru Alexandra Sabina Cojocariu Andra Oancea Maria-Magdalena Leon-Constantin Mihai Roca Ioana Mdlina Zota Irina Mihaela Abdulan Cristina Rusu Laura Mihaela Trandafir Alexandru Dan Costache Elena Cojocaru Iulia Cristina Roca Florin Mitu 《Nutrients》2022,14(15)
(1) Background: Familial hypercholesterolemia (FH) is a genetic autosomal dominant disorder characterized by elevated levels of low-density lipoprotein cholesterol (LDL) that develops deposits of lipids in the arterial wall. Since it is underdiagnosed and undertreated, the disease has a high risk of premature cardiovascular disease and death. Patients are not always aware of the changes they should make in their diet. Thus, our study aimed to evaluate through a food frequency questionnaire their eating habits. (2) Methods: We included 70 patients with FH and 20 subjects in a control group that were evaluated through a physical examination and blood tests. They also completed a food frequency questionnaire. (3) Results: Throughout our study, we observed several aspects: regardless of age, patients with FH had higher carbohydrate intakes compared to the control group; from the same group, a positive correlation was observed between salami intake and the levels of glucose and glycated hemoglobin. Moreover, the sour cream preference was associated with higher liver function tests. In the control group, we observed a higher intake of pasta and fast food and fewer fruit portions. (4) Conclusions: As far as we know, this is the first study from Romania that evaluated the eating habits of patients diagnosed with FH. Our study reveals that, although patients with FH avoid junk food, they still have a high intake of carbohydrates when compared to the control group. Further research is needed in order to get a comprehensive nutritional evaluation of these patients. 相似文献
203.
Paola Ungaro Immacolata Cristina Nettore Fabiana Franchini Giuseppe Palatucci Giovanna Muscogiuri Annamaria Colao Paolo Emidio Macchia 《Nutrients》2022,14(15)
Ketogenic diets (KD) are dietary strategies low in carbohydrates, normal in protein, and high, normal, or reduced in fat with or without (Very Low-Calories Ketogenic Diet, VLCKD) a reduced caloric intake. KDs have been shown to be useful in the treatment of obesity, metabolic diseases and related disorders, neurological diseases, and various pathological conditions such as cancer, nonalcoholic liver disease, and chronic pain. Several studies have investigated the intracellular metabolic pathways that contribute to the beneficial effects of these diets. Although epigenetic changes are among the most important determinants of an organism’s ability to adapt to environmental changes, data on the epigenetic changes associated with these dietary pathways are still limited. This review provides an overview of the major epigenetic changes associated with KDs. 相似文献
204.
Marielle E. Yohe Christine M. Heske Elizabeth Stewart Peter C. Adamson Nabil Ahmed Cristina R. Antonescu Eleanor Chen Natalie Collins Alan Ehrlich Rene L. Galindo Berkley E. Gryder Heidi Hahn Sharon Hammond Mark E. Hatley Douglas S. Hawkins Madeline N. Hayes Andrea Hayes‐Jordan Lee J. Helman Simone Hettmer Myron S. Ignatius Charles Keller Javed Khan David G. Kirsch Corinne M. Linardic Philip J. Lupo Rossella Rota Jack F. Shern Janet Shipley Sivasish Sindiri Stephen J. Tapscott Christopher R. Vakoc Leonard H. Wexler David M. Langenau 《Pediatric blood & cancer》2019,66(10)
Overall survival rates for pediatric patients with high‐risk or relapsed rhabdomyosarcoma (RMS) have not improved significantly since the 1980s. Recent studies have identified a number of targetable vulnerabilities in RMS, but these discoveries have infrequently translated into clinical trials. We propose streamlining the process by which agents are selected for clinical evaluation in RMS. We believe that strong consideration should be given to the development of combination therapies that add biologically targeted agents to conventional cytotoxic drugs. One example of this type of combination is the addition of the WEE1 inhibitor AZD1775 to the conventional cytotoxic chemotherapeutics, vincristine and irinotecan. 相似文献
205.
Roberto Orecchia Umberto Veronesi Patrick Maisonneuve Viviana Enrica Galimberti Roberta Lazzari Paolo Veronesi Barbara Alicja Jereczek-Fossa Federica Cattani Claudia Sangalli Alberto Luini Pietro Caldarella Marco Venturino Daniele Sances Stefano Zurrida Giuseppe Viale Maria Cristina Leonardi Mattia Intra 《The lancet oncology》2021,22(5):597-608
206.
Antonio Jimeno Cristina Grávalos Pilar Escudero Isabel Sevilla M. Eugenia Vega-Villegas Vicente Alonso Ignacio Juez Rocío García-Carbonero Humberto Bovio Ramón Colomer Hernán Cortés-Funes 《Clinical & translational oncology》2008,10(1):52-57
Objective The objectives of this phase I/II study were to determine the maximum tolerated dose (MTD), characterise the principal toxicities
in the phase I part and assess the efficacy in the phase II part of gefitinib, an oral selective inhibitor of the epidermal
growth factor receptor, in combination with capecitabine in patients with advanced colorectal cancer (CRC).
Methods and patients Patients with advanced CRC were treated with gefitinib administered daily for 21 days and capecitabine administered twice
daily for 14 days of a 21-day cycle. The dose levels of gefitinib (mg) and capecitabine (mg/m2 bid) assessed were 250/1000 and 250/ 1250. An expanded cohort was enrolled at the MTD to better characterise toxicity and
efficacy. A total of 32 previously treated patients were accrued. In the phase I part 10 subjects were treated, with one dose-limiting
toxicity. Overall 26 patients were treated at the MTD of the combination, which was gefitinib 250 mg/day and capecitabine
1250 mg/m2 twice daily.
Results The most frequent treatment-related adverse events included asthenia, diarrhoea, nausea, rash and anorexia. The incidence
profile was very similar in phases I and II. No objective responses were documented but 53% of the patients achieved stable
disease as best response to therapy.
Conclusions Capecitabine 1250 mg/m2 twice daily 14 of 21 days and gefitinib at 250 mg/day can be safely administered in combination. The combination is relatively
well tolerated. There were no objective responses, although an interesting stabilisation rate was documented, in previously
treated advanced CRC patients. 相似文献
207.
Martina Aida Angeles Federico Migliorelli Sergi Vidal-Sicart Adela Saco Jaume Ordi Cristina Ros Pere Fust Meritxell Munmany Sílvia Escura Núria Carreras Nuria Snchez-Izquierdo Jaume Pahisa Aureli Torn Pilar Paredes Marta del Pino 《Journal Of Gynecologic Oncology》2021,32(4)
ObjectiveWe aimed to evaluate the accuracy of sentinel lymph node (SLN) mapping with transvaginal ultrasound-guided myometrial injection of radiotracer (TUMIR) to detect lymph node (LN) metastases, in patients with intermediate and high-risk endometrial cancer (EC), focusing on its performance to detect paraaortic involvement.MethodsProspective study including women with preoperative intermediate or high-risk EC, according to ESMO-ESGO-ESTRO consensus, who underwent SLN mapping using the TUMIR approach. SLNs were preoperatively localized by planar and single photon emission computed tomography/computed tomography images, and intraoperatively by gamma-probe. Immediately after SLN excision, all women underwent systematic pelvic and paraaortic lymphadenectomy by laparoscopy.ResultsThe study included 102 patients. The intraoperative SLN detection rate was 79.4% (81/102). Pelvic and paraaortic drainage was observed in 92.6% (75/81) and 45.7% (37/81) women, respectively, being exclusively paraaortic in 7.4% (6/81). After systematic lymphadenectomy, LN metastases were identified in 19.6% (20/102) patients, with 45.0% (9/20) showing paraaortic involvement, which was exclusive in 15.0% (3/20). The overall sensitivity and negative predictive value (NPV) of SLNs by the TUMIR approach to detect lymphatic involvement were 87.5% and 97.0%, respectively; and 83.3% and 96.9%, for paraaortic metastases. After applying the MSKCC SLN mapping algorithm, the sensitivity and NPV were 93.8% and 98.5%, respectively.ConclusionThe TUMIR method provides valuable information of endometrial drainage in patients at higher risk of paraaortic LN involvement. The TUMIR approach showed a detection rate of paraaortic SLNs greater than 45% and a high sensitivity and NPV for paraaortic metastases in women with intermediate and high-risk EC. 相似文献
208.
Carroli G Cuesta C Abalos E Gulmezoglu AM 《Best practice & research. Clinical obstetrics & gynaecology》2008,22(6):999-1012
Postpartum haemorrhage (PPH) is an important cause of maternal mortality. We conducted a systematic review of the prevalence of PPH with the objective of evaluating its magnitude both globally and in different regions and settings: global figures, as well as regional, country and provincial variations, are likely to exist but are currently unknown. We used prespecified criteria to select databases, recorded the database characteristics and assessed their methodological quality. After establishing PPH (>or=500 mL blood loss) and severe PPH (SSPH) (>or=1000 mL blood loss) as main outcomes, we found 120 datasets (involving a total of 3,815,034 women) that reported PPH and 70 datasets (505,379 women) that reported SPPH in the primary analysis. The prevalence of PPH and SPPH is approximately 6% and 1.86% of all deliveries, respectively, with a wide variation across regions of the world. The figures we obtained give a rough estimate of the prevalence of PPH and suggest the existence of some variations. For a reliable picture of PPH worldwide - its magnitude, distribution and consequences - a global survey tackling this condition is necessary. 相似文献
209.
Tatad AM Nesin M Peoples J Cheung S Lin H Sison C Perlman J Cunningham-Rundles S 《Neonatology》2008,94(1):8-15
BACKGROUND: Neonatal susceptibility to bacterial infection is associated with an immature immune system, but the role of different bacterial antigens in specific responses is largely unknown. OBJECTIVE: To evaluate differences in intracellular cytokine response to physiologically relevant bacterial antigens in term and preterm infants as compared with adults. METHODS: Cord blood samples from preterm and term neonates and adult peripheral blood samples were cultured ex vivo with and without whole heat-killed bacteria. Intracellular leukocyte production of interleukin (IL)-6, IL-10, IL-12, and IL-8 responses was assessed by flow cytometry. RESULTS: Monocytes were the primary producers of all mediators. Escherichia coli was the most potent stimulant. Lactobacillus plantarum 299v activated fewer monocytes as compared with E. coli for all responses (p < 0.05), except for IL-12 in term neonates. IL-6 response to Staphylococcus epidermidis was lower in both groups of neonates as compared with adults (p = 0.023 and p = 0.001). IL-8 response to S. epidermidis was lower in term as compared with preterm neonates and adults (p = 0.003). IL-10 response to group B streptococci was lower in term neonates as compared with adults and higher in preterm as compared with term neonates (p = 0.015). CONCLUSIONS: Monocytes from term neonates compared to preterm neonates show a downregulated anti-inflammatory response to specific bacteria. High neonatal response to pathogenic E. coli in the preterm infant could cause uncontrolled inflammatory response, while lower IL-6 response to S. epidermidis in neonates may indicate a basis for vulnerability to S. epidermidis infection. 相似文献
210.
Antiviral effects of Glycyrrhiza species 总被引:1,自引:0,他引:1
Fiore C Eisenhut M Krausse R Ragazzi E Pellati D Armanini D Bielenberg J 《Phytotherapy research : PTR》2008,22(2):141-148