全文获取类型
收费全文 | 1332篇 |
免费 | 80篇 |
国内免费 | 26篇 |
专业分类
耳鼻咽喉 | 9篇 |
儿科学 | 95篇 |
妇产科学 | 19篇 |
基础医学 | 131篇 |
口腔科学 | 13篇 |
临床医学 | 133篇 |
内科学 | 306篇 |
皮肤病学 | 13篇 |
神经病学 | 69篇 |
特种医学 | 66篇 |
外科学 | 140篇 |
综合类 | 54篇 |
一般理论 | 1篇 |
预防医学 | 61篇 |
眼科学 | 56篇 |
药学 | 102篇 |
中国医学 | 1篇 |
肿瘤学 | 169篇 |
出版年
2022年 | 5篇 |
2021年 | 13篇 |
2020年 | 17篇 |
2019年 | 21篇 |
2018年 | 43篇 |
2017年 | 28篇 |
2016年 | 27篇 |
2015年 | 21篇 |
2014年 | 39篇 |
2013年 | 59篇 |
2012年 | 62篇 |
2011年 | 80篇 |
2010年 | 46篇 |
2009年 | 42篇 |
2008年 | 53篇 |
2007年 | 56篇 |
2006年 | 50篇 |
2005年 | 54篇 |
2004年 | 50篇 |
2003年 | 57篇 |
2002年 | 43篇 |
2001年 | 39篇 |
2000年 | 27篇 |
1999年 | 20篇 |
1998年 | 27篇 |
1997年 | 24篇 |
1996年 | 25篇 |
1995年 | 12篇 |
1994年 | 26篇 |
1993年 | 19篇 |
1992年 | 34篇 |
1991年 | 43篇 |
1990年 | 29篇 |
1989年 | 28篇 |
1988年 | 31篇 |
1987年 | 31篇 |
1986年 | 18篇 |
1985年 | 19篇 |
1984年 | 15篇 |
1983年 | 13篇 |
1982年 | 8篇 |
1981年 | 12篇 |
1980年 | 17篇 |
1979年 | 6篇 |
1978年 | 6篇 |
1977年 | 6篇 |
1973年 | 4篇 |
1972年 | 7篇 |
1971年 | 5篇 |
1969年 | 3篇 |
排序方式: 共有1438条查询结果,搜索用时 15 毫秒
51.
María Julieta Russo Mónica Iturry María Alejandra Sraka Leonardo Bartoloni Cristóbal Carnero Pardo Ricardo Francisco Allegri 《The Clinical neuropsychologist》2014,28(5):826-840
Phototest is a simple, easy and very brief test with theoretical advantages over available dementia screening tests in Spain. The objective of this study was to estimate the diagnostic accuracy of the Phototest for cognitive impairment and dementia and to compare it with that of the MMSE and the Clock Drawing Test (CDT) in an Argentine population. A phase II cross-sectional study of diagnostic tests evaluation was performed in a sample of 30 controls, 61 with amnestic mild cognitive impairment (a-MCI), and 56 with mild Alzheimer type dementia (DAT). The diagnostic accuracy (DA) was assessed in relation to the clinical diagnosis by calculating the area under the ROC curve (UAC), Sensitivity (Sn), and Specificity (Sp).The DA of the Phototest for a-MCI and DAT (0.93 and 0.97 [UAC]) was higher than that of the MMSE and the CDT. The cut-off points of 27/28 for DAT (Sn = 89.29 [78.1–96.0], Sp = 96.67 [82.8–99.9]) and 30/31 for a-MCI (Sn = 85.25 [73.8–93.0], Sp = 90.00 [73.5–97.9]) maximized the sum of Sn and Sp. Phototest correlates significantly with MMSE and CDT. The Phototest is an efficient instrument for the detection of mild dementia or MCI, with good accuracy and good correlation with tests measuring overall cognitive impairment. 相似文献
52.
Thiago Santos Ferreira Manuella Lanzetti Marina Valente Barroso Carlos Romualdo Rueff-Barroso Cláudia Farias Benjamim Lycia de Brito-Gitirana Luís Cristóvão Porto Samuel Santos Valença 《Inflammation》2014,37(5):1355-1365
Our aim was to investigate the effects of four different statins on acute lung inflammation induced by cigarette smoke (CS). C57BL/6 male mice were divided into a control group (sham-smoked) and mice exposed to CS from 12 cigarettes/day for 5 days. Mice exposed to CS were grouped and treated with vehicle (i.p.), atorvastatin (10 mg/kg), pravastatin (10 mg/kg), rosuvastatin (5 mg/kg), or simvastatin (20 mg/kg). Treatment with statins differentially improved the pulmonary response when compared to the CS group. Atorvastatin and pravastatin demonstrated slightly effects on inflammation and oxidative stress. Rosuvastatin demonstrated the best anti-inflammatory effect, whereas simvastatin demonstrated the best antioxidant response. 相似文献
53.
Jiménez Isabel Carabia Júlia Bobillo Sabela Palacio Carles Abrisqueta Pau Pagès Carlota Nieto Juan C. Castellví Josep Martínez-Ricarte Francisco Escoda Lourdes Perla Cristóbal Céspedes Torrez Dennis H. Boix Joan Purroy Noelia Puigdefàbregas Lluís Seoane Joan Bosch Francesc Crespo Marta 《Journal of neuro-oncology》2020,149(1):13-25
Journal of Neuro-Oncology - Patients diagnosed with primary central nervous system lymphoma (PCNSL) often face dismal outcomes due to the limited availability of therapeutic options. PCNSL cells... 相似文献
54.
Gabriela A. Merino Yanina A. Murua Cristóbal Fresno Juan M. Sendoya Mariano Golubicki Soledad Iseas Mariana Coraglio Osvaldo L. Podhajcer Andrea S. Llera Elmer A. Fernández 《Human mutation》2017,38(5):494-502
Targeted sequencing (TS) is growing as a screening methodology used in research and medical genetics to identify genomic alterations causing human diseases. In general, a list of possible genomic variants is derived from mapped reads through a variant calling step. This processing step is usually based on variant coverage, although it may be affected by several factors. Therefore, undercovered relevant clinical variants may not be reported, affecting pathology diagnosis or treatment. Thus, a prior quality control of the experiment is critical to determine variant detection accuracy and to avoid erroneous medical conclusions. There are several quality control tools, but they are focused on issues related to whole‐genome sequencing. However, in TS, quality control should assess experiment, gene, and genomic region performances based on achieved coverages. Here, we propose TarSeqQC R package for quality control in TS experiments. The tool is freely available at Bioconductor repository. TarSeqQC was used to analyze two datasets; low‐performance primer pools and features were detected, enhancing the quality of experiment results. Read count profiles were also explored, showing TarSeqQC's effectiveness as an exploration tool. Our proposal may be a valuable bioinformatic tool for routinely TS experiments in both research and medical genetics. 相似文献
55.
Comparison of a rapid latex agglutination assay and a fluorescent-antibody technique for the detection of herpes simplex antibody 总被引:1,自引:0,他引:1
W D LeBar C M Resek A E Crist R L Sautter 《Diagnostic microbiology and infectious disease》1988,11(1):21-24
A total of 202 serum specimens was tested for the presence of herpes simplex virus antibody using a premarket latex agglutination kit (Wampole) and an indirect fluorescent antibody (IFA) technique (electronucleonics). Discrepant results between the two assays were resolved using an Enzyme-linked immunosorbent assay (ELISA) procedure. The overall sensitivity of the latex was 99.2% with a specificity of 98.5%. The latex agglutination test evaluated is a viable alternative to indirect immunofluorescence for the detection of herpes simplex virus antibody in serum samples. 相似文献
56.
Thirty-two college student subjects were selected on the basis of scores on the Creative Imagination Scale. Eight of the high suggestibility subjects were assigned randomly to each training mode, progressive relaxation (PR) and suggestions of relaxation (SR). The 16 low suggestibility subjects were similarly assigned, which resulted in a 2 × 2 factorial design with one repeated measure, a pre-post relaxation scale that yields a total score and three subscale scores. A significant pre-post relaxation effect emerged. Main effects were found both for suggestibility and mode of training. High suggestibility subjects performed significantly better regardless of the training mode. PR yielded significantly higher relaxation scores than did SR. An interaction between suggestibility and training mode occurred on the cognitive factor scale; subjects who scored low on suggestibility reported relaxing significantly better when the training mode was PR. 相似文献
57.
D. Galán Madruga R. Fernández Patier M. A. Sintes Puertas M. D. Romero García A. Cristóbal López 《Bulletin of environmental contamination and toxicology》2018,100(4):593-599
Ammonia levels were evaluated in the urban environment of Madrid City, Spain. A total of 110 samplers were distributed throughout the city. Vehicle traffic density, garbage containers and sewers were identified as local emission sources of ammonia. The average ammonia concentrations were 4.66?±?2.14 µg/m3 (0.39–11.23 µg/m3 range) in the winter and 5.30?±?1.81 µg/m3 (2.33–11.08 µg/m3 range) in the summer. Spatial and seasonal variations of ammonia levels were evaluated. Hotspots were located in the south and center of Madrid City in both winter and summer seasons, with lower ammonia concentrations located in the north (winter) and in the west and east (summer). The number of representative points that were needed to establish a reliable air quality monitoring network for ammonia was determined using a combined clustering and kriging approach. The results indicated that 40 samplers were sufficient to provide a reliable estimate for Madrid City. 相似文献
58.
Nicolás García MD Julio Rosales MD Cristóbal Greene MD Guillermo Droppelmann MSc PhD Marco A. Verdugo MD 《Journal of ultrasound in medicine》2020,39(1):165-168
The aim of this study was to describe a perineural ultrasound-guided infiltration technique for management of radial tunnel syndrome and to report its preliminary results in 54 patients. A mixture of a saline solution, a local anesthetic, and a corticosteroid solution was infiltrated in the perineural region at the arcade of Frohse. Pain was reported in 100% of patients before the procedure versus 1.9% after the procedure. Scratch collapse and Cozen test results were positive in 98.1% and 66.7% of patients before infiltration, respectively, versus 5.6% and 9.2% after infiltration. All variables had statistically significant differences between preprocedure and postprocedure evaluations (P < .01). 相似文献
59.
Knowledge,attitude and practice among Health Visitors in the United Kingdom toward children's oral health 下载免费PDF全文
60.
Aravena T Passalacqua C Pizarro O Aracena M 《American journal of medical genetics. Part A》2011,(10):2552-2555
The Gorlin-Chaudhry-Moss syndrome (GCMS), was describe initially by Gorlin et al. [Gorlin et al. (1960)] in two sisters with craniosynostosis, hypertrichosis, hypoplastic labia majora, dental defects, eye anomalies, patent ductus arteriosus, and normal intelligence. Two other sporadic instances have been documented. Here, we report on two sisters with a condition with some similarities to GCMS as well as some differences, which could represent either previously unreported variability in GCMS, or it may represent a novel disorder. 相似文献