全文获取类型
收费全文 | 5121篇 |
免费 | 337篇 |
国内免费 | 17篇 |
专业分类
耳鼻咽喉 | 65篇 |
儿科学 | 171篇 |
妇产科学 | 98篇 |
基础医学 | 585篇 |
口腔科学 | 67篇 |
临床医学 | 502篇 |
内科学 | 924篇 |
皮肤病学 | 48篇 |
神经病学 | 600篇 |
特种医学 | 302篇 |
外科学 | 552篇 |
综合类 | 250篇 |
一般理论 | 5篇 |
预防医学 | 489篇 |
眼科学 | 142篇 |
药学 | 436篇 |
1篇 | |
中国医学 | 6篇 |
肿瘤学 | 232篇 |
出版年
2023年 | 35篇 |
2022年 | 110篇 |
2021年 | 211篇 |
2020年 | 78篇 |
2019年 | 127篇 |
2018年 | 164篇 |
2017年 | 105篇 |
2016年 | 136篇 |
2015年 | 121篇 |
2014年 | 171篇 |
2013年 | 241篇 |
2012年 | 252篇 |
2011年 | 236篇 |
2010年 | 191篇 |
2009年 | 183篇 |
2008年 | 183篇 |
2007年 | 185篇 |
2006年 | 188篇 |
2005年 | 183篇 |
2004年 | 157篇 |
2003年 | 141篇 |
2002年 | 151篇 |
2001年 | 112篇 |
2000年 | 145篇 |
1999年 | 134篇 |
1998年 | 66篇 |
1997年 | 57篇 |
1996年 | 44篇 |
1995年 | 42篇 |
1994年 | 46篇 |
1993年 | 43篇 |
1992年 | 85篇 |
1991年 | 66篇 |
1990年 | 66篇 |
1989年 | 77篇 |
1988年 | 60篇 |
1987年 | 67篇 |
1986年 | 72篇 |
1985年 | 66篇 |
1984年 | 58篇 |
1983年 | 43篇 |
1982年 | 57篇 |
1981年 | 36篇 |
1980年 | 36篇 |
1979年 | 34篇 |
1978年 | 25篇 |
1977年 | 34篇 |
1976年 | 26篇 |
1975年 | 27篇 |
1974年 | 28篇 |
排序方式: 共有5475条查询结果,搜索用时 15 毫秒
91.
92.
93.
McGinnis Kathleen A. Tate Janet P. Bryant Kendall J. Justice Amy C. O’Connor Patrick G. Rodriguez-Barradas Maria C. Crystal Stephen Cutter Christopher J. Hansen Nathan B. Maisto Stephen A. Marconi Vincent C. Williams Emily C. Cook Robert L. Gordon Adam J. Gordon Kirsha S. Eyawo Oghenowede Edelman E. Jennifer Fiellin David A. 《AIDS and behavior》2022,26(3):786-794
AIDS and Behavior - The timeline followback (TLFB) takes more resources to collect than the Alcohol Use Disorder Identification Test (AUDIT-C). We assessed agreement of TLFB and AUDIT-C with the... 相似文献
94.
Bajwa Farhan O’Connor Ryan Ananthasubramaniam Karthikeyan 《Heart failure reviews》2022,27(5):1471-1484
Heart Failure Reviews - Cardiac amyloidosis, once considered a rare disease, has garnered significant attention over the last few years due to three key reasons: first, increased... 相似文献
95.
Coakley G; Mok CC; Hajeer AH; Ollier WE; Turner D; Sinnott PJ; Hutchinson IV; Panayi GS; Lanchbury JS 《Rheumatology (Oxford, England)》1998,37(9):988-991
OBJECTIVE: To examine whether promoter polymorphisms associated with
variation in interleukin-10 (IL-10) production are relevant to the
development of rheumatoid arthritis (RA) or Felty's syndrome (FS). METHODS:
DNA was obtained from 44 FS patients, 117 RA patients and 295 controls. The
promoter region between -533 and - 1120 was amplified by polymerase chain
reaction, and polymorphisms detected by restriction enzyme digest or
sequence-specific oligonucleotide probing. RESULTS: We found no significant
difference in allele or haplotype frequencies between the groups.
CONCLUSION: There is no association between FS or RA and these recently
identified IL-10 promoter polymorphisms. Other genetic or environmental
factors could explain the alterations in IL-10 levels seen in these
conditions.
相似文献
96.
97.
98.
Hereditary pancreatic endocrine tumours. 总被引:2,自引:0,他引:2
N Alexakis S Connor P Ghaneh M Lombard H L Smart J Evans M Hughes C J Garvey J Vora S Vinjamuri R Sutton J P Neoptolemos 《Pancreatology》2004,4(5):417-33; discussion 434-5
The two main types of hereditary pancreatic neuroendocrine tumours are found in multiple endocrine neoplasia type 1 (MEN-1) and von Hippel-Lindau disease (VHL), but also in the rarer disorders of neurofibromatosis type 1 and tuberous sclerosis. This review considers the major advances that have been made in genetic diagnosis, tumour localization, medical and surgical treatment and palliation with systemic chemotherapy and radionuclides. With the exception of the insulinoma syndrome, all of the various hormone excess syndromes of MEN-1 can be treated medically. The role of surgery however remains controversial ranging from no intervention (except enucleation for insulinoma), intervening for tumours diagnosed only by biochemical criteria, intervening in those tumours only detected radiologically (1-2 cm in diameter) or intervening only if the tumour diameter is > 3 cm in diameter. The extent of surgery is also controversial, although radical lymphadenectomy is generally recommended. Pancreatic tumours associated with VHL are usually non-functioning and tumours of at least 2 cm in diameter should be resected. Practice guidelines recommend that screening in patients with MEN-1 should commence at the age of 5 years for insulinoma and at the age of 20 years for other pancreatic neuroendocrine tumours and variously at 10-20 years of age for pancreatic tumours in patients with VHL. The evidence is increasing that the life span of patients may be significantly improved with surgical intervention, mandating the widespread use of tumour surveillance and multidisciplinary team management. 相似文献
99.
Yisi Lu Roy Jiang Alec W. Freyn Jiawei Wang Shirin Strohmeier Katlyn Lederer Michela Locci Hongyu Zhao Davide Angeletti Kevin C. OConnor Steven H. Kleinstein Raffael Nachbagauer Joe Craft 《The Journal of experimental medicine》2021,218(3)
CD4+ follicular regulatory T (Tfr) cells control B cell responses through the modulation of follicular helper T (Tfh) cells and germinal center development while suppressing autoreactivity; however, their role in the regulation of productive germinal center B cell responses and humoral memory is incompletely defined. We show that Tfr cells promote antigen-specific germinal center B cell responses upon influenza virus infection. Following viral challenge, we found that Tfr cells are necessary for robust generation of virus-specific, long-lived plasma cells, antibody production against both hemagglutinin (HA) and neuraminidase (NA), the two major influenza virus glycoproteins, and appropriate regulation of the BCR repertoire. To further investigate the functional relevance of Tfr cells during viral challenge, we used a sequential immunization model with repeated exposure of antigenically partially conserved strains of influenza viruses, revealing that Tfr cells promote recall antibody responses against the conserved HA stalk region. Thus, Tfr cells promote antigen-specific B cell responses and are essential for the development of long-term humoral memory. 相似文献
100.
Cost Katherine T. Zaidman-Zait Anat Mirenda Pat Duku Eric Zwaigenbaum Lonnie Smith Isabel M. Ungar Wendy J. Kerns Connor Bennett Theresa Szatmari Peter Georgiades Stelios Waddell Charlotte Elsabbagh Mayada Vaillancourt Tracy 《Journal of autism and developmental disorders》2021,51(12):4575-4576
Journal of Autism and Developmental Disorders - 相似文献