全文获取类型
收费全文 | 171303篇 |
免费 | 8339篇 |
国内免费 | 460篇 |
专业分类
耳鼻咽喉 | 2501篇 |
儿科学 | 5539篇 |
妇产科学 | 4670篇 |
基础医学 | 23539篇 |
口腔科学 | 4775篇 |
临床医学 | 11509篇 |
内科学 | 39309篇 |
皮肤病学 | 5605篇 |
神经病学 | 13971篇 |
特种医学 | 3984篇 |
外国民族医学 | 31篇 |
外科学 | 22174篇 |
综合类 | 884篇 |
一般理论 | 40篇 |
预防医学 | 17571篇 |
眼科学 | 3524篇 |
药学 | 12189篇 |
中国医学 | 551篇 |
肿瘤学 | 7736篇 |
出版年
2023年 | 917篇 |
2022年 | 1566篇 |
2021年 | 3743篇 |
2020年 | 1978篇 |
2019年 | 3718篇 |
2018年 | 5017篇 |
2017年 | 3199篇 |
2016年 | 3229篇 |
2015年 | 3541篇 |
2014年 | 4675篇 |
2013年 | 6846篇 |
2012年 | 10245篇 |
2011年 | 10603篇 |
2010年 | 5882篇 |
2009年 | 5044篇 |
2008年 | 8683篇 |
2007年 | 9141篇 |
2006年 | 8972篇 |
2005年 | 8923篇 |
2004年 | 8342篇 |
2003年 | 7750篇 |
2002年 | 7444篇 |
2001年 | 5445篇 |
2000年 | 5638篇 |
1999年 | 4678篇 |
1998年 | 1299篇 |
1997年 | 930篇 |
1996年 | 882篇 |
1995年 | 759篇 |
1994年 | 638篇 |
1992年 | 2350篇 |
1991年 | 2227篇 |
1990年 | 2070篇 |
1989年 | 1831篇 |
1988年 | 1644篇 |
1987年 | 1609篇 |
1986年 | 1490篇 |
1985年 | 1438篇 |
1984年 | 1060篇 |
1983年 | 908篇 |
1979年 | 1024篇 |
1978年 | 679篇 |
1975年 | 693篇 |
1974年 | 896篇 |
1973年 | 873篇 |
1972年 | 759篇 |
1971年 | 709篇 |
1970年 | 763篇 |
1969年 | 727篇 |
1968年 | 686篇 |
排序方式: 共有10000条查询结果,搜索用时 15 毫秒
11.
C.Z. Simonsen S. Schnenberger P.L. Hendn A.J. Yoo L. Uhlmann A. Rentzos J. Bsel J. Valentin M. Rasmussen 《AJNR. American journal of neuroradiology》2020,41(12):2298
BACKGROUND AND PURPOSE:Endovascular therapy for acute ischemic stroke is often performed with the patient under conscious sedation. Emergent conversion from conscious sedation to general anesthesia is sometimes necessary. The aim of this study was to assess the functional outcome in converted patients compared with patients who remained in conscious sedation and to identify predictors associated with the risk of conversion.MATERIALS AND METHODS:Data from 368 patients, included in 3 trials randomizing between conscious sedation and general anesthesia before endovascular therapy (SIESTA, ANSTROKE, and GOLIATH) constituted the study cohort. Twenty-one (11%) of 185 patients randomized to conscious sedation were emergently converted to general anesthesia.RESULTS:Absence of hyperlipidemia seemed to be the strongest predictor of conversion to general anesthesia, albeit a weak predictor (area under curve = 0.62). Sex, hypertension, diabetes, smoking status, atrial fibrillation, blood pressure, size of the infarct, and level and side of the occlusion were not significantly associated with conversion to general anesthesia. Neither age (mean age, 71.3 ± 13.8 years for conscious sedation versus 71.6 ± 12.3 years for converters, P = .58) nor severity of stroke (mean NIHSS score, 17 ± 4 versus 18 ± 4, respectively, P = .27) were significantly different between converters and those who tolerated conscious sedation. The converters had significantly worse outcome with a common odds ratio of 2.67 (P = .015) for a shift toward a higher mRS score compared with the patients remaining in the conscious sedation group.CONCLUSIONS:Patients undergoing conversion had significantly worse outcome compared with patients remaining in conscious sedation. No factor was identified that predicted conversion from conscious sedation to general anesthesia.Five studies published in 2015 proved the efficacy of endovascular therapy (EVT) for acute ischemic stroke caused by a large-vessel occlusion.1 However, numerous questions remain regarding how to best deliver this treatment, including evaluation of the optimal thrombectomy technique,2 the most effective method of patient triage,3 or whether EVT should be performed with the patient under either general anesthesia (GA) or conscious sedation (CS).Observational studies have suggested that EVT with the patient under CS is associated with better neurologic outcome and lower mortality compared with GA.4 However, 3 randomized trials reported similar outcomes between CS and GA.5-7 Proposed benefits of CS include stable hemodynamics, clinical monitoring, and a potentially shorter procedure. The disadvantages are an unprotected airway and patient movement, which sometimes may require emergent conversion to GA. Patients who need conversion might be sicker (larger strokes, more medical complications), but the conversion procedure itself may also have a potentially deleterious influence on outcome due to the emergent anesthetic induction, associated hypotension, and added time delay before reperfusion.Although most patients can be treated under the less complex CS, it is of interest to identify factors that can predict the risk of conversion and hence the requirement for GA. We undertook a detailed analysis of the patients who were converted from CS to GA in our individual patient data base from the 3 randomized trials to examine the outcome of the converted patients compared with patients who remained in CS. We also aimed to identify possible predictors associated with a need for GA with EVT. 相似文献
12.
13.
Claire Letournel François Babinet Bénédicte Allard Vincent Montecot 《Néphrologie & thérapeutique》2019,15(1):51-58
Objective
The “Centre Hospitalier Francois Dunan” is located on an isolated island and ensures patients care in hemodialysis thanks to telemedicine support. Many research studies have demonstrated the importance of hemodialysis fluids composition to reduce morbidity in patients on chronic hemodialysis. The aim of this study was to identify the risks inherent in the production of dialysis fluids in a particular context, in order to set up an improvement action plan to improve risk control on the production of dialysis fluids.Methods
The risk analysis was conducted with the FMECA methodology (Failure Mode, Effects and Criticality Analysis) by a multi professional work group. Three types of risk have been reviewed: technical risks that may impact the production of hemodialysis fluids, health risks linked with chemical composition and health risks due to microbiological contamination of hemodialysis fluids.Results
The work group, in close cooperation with the expert staff of the dialysis center providing telemedicine assistance, has developed an action plan in order to improve the control of the main risks brought to light by the risk analysis.Conclusion
The exhaustive analysis of the risks and their prioritisation have permitted to establish a relevant action plan in this improving quality of dialysis fluids approach. The risk control of dialysis fluids is necessary for the security of dialysis sessions for patients, even more when these sessions are realized by telemedicine in Saint-Pierre-et-Miquelon. 相似文献14.
R. Di Raimondo J. Sanz-Esporrn R. Pl I. Sanz-Martn F. Luengo F. Vignoletti J. Nuez Mariano Sanz 《Clinical oral investigations》2020,24(7):2351-2361
To evaluate the changes in alveolar contour after guided bone regeneration (GBR) with two different combinations of biomaterials in dehiscence defects arou 相似文献
15.
16.
17.
18.
19.
20.
Rosario Gulias-Cañizo Anell Lagunes-Guillén Arturo González-Robles Erika Sánchez-Guzmán Federico Castro-Muñozledo 《Burns : journal of the International Society for Burn Injuries》2019,45(2):398-412