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81.
Gabriela Balikova Novotna Min Jung Kwun Hee-Jeon Hong 《Antimicrobial agents and chemotherapy》2016,60(3):1627-1637
The VanR-VanS two-component system is responsible for inducing resistance to glycopeptide antibiotics in various bacteria. We have performed a comparative study of the VanR-VanS systems from two streptomyces strains, Streptomyces coelicolor and Streptomyces toyocaensis, to characterize how the two proteins cooperate to signal the presence of antibiotics and to define the functional nature of each protein in each strain background. The results indicate that the glycopeptide antibiotic inducer specificity is determined solely by the differences between the amino acid sequences of the VanR-VanS two-component systems present in each strain rather than by any inherent differences in general cell properties, including cell wall structure and biosynthesis. VanR of S. coelicolor (VanRsc) functioned with either sensor kinase partner, while VanR of S. toyocaensis (VanRst) functioned only with its cognate partner, S. toyocaensis VanS (VanSst). In contrast to VanRsc, which is known to be capable of phosphorylation by acetylphosphate, VanRst could not be activated in vivo independently of a VanS sensor kinase. A series of amino acid sequence modifications changing residues in the N-terminal receiver (REC) domain of VanRst to the corresponding residues present in VanRsc failed to create a protein capable of being activated by VanS of S. coelicolor (VanSsc), which suggests that interaction of the response regulator with its cognate sensor kinase may require a region more extended than the REC domain. A T69S amino acid substitution in the REC domain of VanRst produced a strain exhibiting weak constitutive resistance, indicating that this particular amino acid may play a key role for VanS-independent phosphorylation in the response regulator protein. 相似文献
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Atisha-Fregoso Yemil Hernández-Ramírez Diego F Olivares-Martínez Elizabeth Núñez-Alvarez Carlos A Llorente Luis Hernández-Molina Gabriela 《Clinical rheumatology》2017,36(3):707-711
Clinical Rheumatology - The objective of this report was to evaluate the ascitic fluid of a patient with refractory lupus ascites (proband) at different time points—pre- and... 相似文献
85.
Gabriela Franco Marques Sadamitsu Nakandakari Ana Paula Cota Pinto Coelho Maria Helena Mazzi Freire Nigro Josmar Sabage 《Anais brasileiros de dermatologia》2014,89(5):812-815
Pseudoxanthoma elasticum is a rare inherited multisystem disorder that is
characterized by a pathological mineralization of the elastic connective tissue,
which involves predominantly the skin, eyes and cardiovascular system. Its cause lies
on mutations in the ABCC6 gene, which lead to reduction or absence of the
transmembrane transport ADP dependent protein (MRP6), causing an accumulation of
extracellular material and subsequent deposition of calcium and other minerals in the
elastic tissue. The authors report two cases of pseudoxanthoma elasticum, emphasizing
its major clinical features and the importance of early diagnosis of the disorder,
aiming for adequate therapeutic management of associated complications. 相似文献
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Isabel G. Quirino Jose Silverio S. Diniz Maria Candida F. Bouzada Alamanda K. Pereira Thais J. Lopes Gabriela M. Paix?o Natalia N. Barros Luisa C. Figueiredo Antonio Carlos V. Cabral Ana Cristina Sim?es e Silva Eduardo A. Oliveira 《Clinical journal of the American Society of Nephrology》2012,7(3):444-451
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Type‐specific persistence and clearance rates of HPV genotypes in the oral and oropharyngeal mucosa in an HIV/AIDS cohort
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