川芎嗪对复氧后损伤心肌细胞的影响

目的：观察川芎嗪对大鼠心室肌细胞缺氧－复氧损伤的作用,方法：在缺氧－复氧条件下,测量对照组和不同浓度川芎嗪组对杆形心肌细胞百分比,心肌细胞释放乳酸脱氢酶（LDH）和心肌细胞类脂过氧化产物－丙二醛（MDA）含量。结果：缺氧－复氧对大鼠心室肌细胞有损伤作用。浓度为4umol/L的川芎开始对缺氧－复氧损伤细胞有保护作用,它能抑制损伤细胞挛缩,提高损伤细胞生存率,抑制细胞LDH的释放,减少MDA的生成,且剂量越大,保护作用越好,即川芎嗪对缺氧－复氧损伤细胞的保护呈剂量依赖性,结论：川芎嗪对缺氧一复氧损伤的心肌细胞具有保护作用。它能显著地对抗缺氧－复氧对心室肌细胞的损伤。     

中国卫生地理信息系统基础数据库的构建

目的：构建可用于中国卫生地理信息系统（GIS）应用研究的基础数据库，以合理应用已有的数据资源，并成为一个空间决策系统。方法：采集不同资料来源，经统一标化后构成基本资料源。主要的资料源包括：（1）覆盖中国地区的卫星遥感图片库；（2）GIS数字化地图库；（3）疾病资料库与相关模型库。结果：已获卫星遥感图片库中的植被指数遥感图片、地面温度遥感图片、数字化高程图片、数字化土地利用图片等；GIS数字化地图库中的中国行政区划数字化地图、环境数据矢量地图、人口分布图、气象资料分布图等；疾病资料库与相关模型库中包括了多种疾病的调查报告、疾病防治年报表等资料，以及疾病的传播模型和媒介／中间宿主潜在自然孳生地模型，及恶性肿瘤发病因素相关图。结论：该数据库的构建使不同来源的数据达到统一性，数据库收集的数据量以足能为国内卫生专业人员应用为前提，希望通过更多疾病的应用，使数据库得以完善。     

Cost-utility of real-time continuous glucose monitoring versus self-monitoring of blood glucose and intermittently scanned continuous glucose monitoring in people with type 1 diabetes receiving multiple daily insulin injections in Denmark

Aims

To determine the cost-effectiveness of the Dexcom G6 real-time continuous glucose monitoring (rt-CGM) system compared with both the self-monitoring of blood glucose (SMBG) and the Abbott FreeStyle Libre 1 and 2 intermittently scanned CGM (is-CGM) devices in people with type 1 diabetes receiving multiple daily insulin injections in Denmark.

Materials and Methods

The analysis was performed using the IQVIA Core Diabetes Model, which associates rt-CGM use with glycated haemoglobin reductions of 0.6% and 0.36% based on data from the DIAMOND and ALERTT1 trials, respectively, compared with SMBG and is-CGM use. The analysis was performed from the payer perspective over a 50-year time horizon; future costs and clinical outcomes were discounted at 4% per annum.

Results

The use of rt-CGM was associated with an incremental gain of 1.37 quality-adjusted life years (QALYs) versus SMBG. Total mean lifetime costs were Danish Krone (DKK) 894 535 for rt-CGM and DKK 823 474 for SMBG, resulting in an incremental cost-utility ratio of DKK 51 918 per QALY gained versus SMBG. Compared with is-CGM, the use of rt-CGM led to a gain of 0.87 QALYs and higher mean lifetime costs resulting in an incremental cost-utility ratio of DKK 40 879 to DKK 34 367 per QALY gained.

Conclusions

In Denmark, the rt-CGM was projected to be highly cost-effective versus both SMBG and is-CGM, based on a willingness-to-pay threshold of 1× per capita gross domestic product per QALY gained. These findings may help inform future policies to address regional disparities in access to rt-CGM.