全文获取类型
收费全文 | 1774篇 |
免费 | 150篇 |
国内免费 | 6篇 |
专业分类
耳鼻咽喉 | 13篇 |
儿科学 | 75篇 |
妇产科学 | 29篇 |
基础医学 | 168篇 |
口腔科学 | 33篇 |
临床医学 | 253篇 |
内科学 | 470篇 |
皮肤病学 | 14篇 |
神经病学 | 164篇 |
特种医学 | 90篇 |
外科学 | 177篇 |
综合类 | 23篇 |
预防医学 | 138篇 |
眼科学 | 20篇 |
药学 | 123篇 |
肿瘤学 | 140篇 |
出版年
2023年 | 18篇 |
2022年 | 13篇 |
2021年 | 22篇 |
2020年 | 14篇 |
2019年 | 22篇 |
2018年 | 47篇 |
2017年 | 19篇 |
2016年 | 36篇 |
2015年 | 39篇 |
2014年 | 73篇 |
2013年 | 75篇 |
2012年 | 96篇 |
2011年 | 118篇 |
2010年 | 59篇 |
2009年 | 82篇 |
2008年 | 88篇 |
2007年 | 76篇 |
2006年 | 96篇 |
2005年 | 90篇 |
2004年 | 90篇 |
2003年 | 96篇 |
2002年 | 83篇 |
2001年 | 31篇 |
2000年 | 24篇 |
1999年 | 47篇 |
1998年 | 33篇 |
1997年 | 40篇 |
1996年 | 41篇 |
1995年 | 36篇 |
1994年 | 32篇 |
1993年 | 23篇 |
1992年 | 21篇 |
1991年 | 15篇 |
1990年 | 18篇 |
1989年 | 38篇 |
1988年 | 15篇 |
1987年 | 12篇 |
1986年 | 19篇 |
1985年 | 19篇 |
1984年 | 16篇 |
1983年 | 19篇 |
1982年 | 16篇 |
1981年 | 10篇 |
1980年 | 14篇 |
1979年 | 5篇 |
1978年 | 7篇 |
1977年 | 6篇 |
1976年 | 6篇 |
1974年 | 5篇 |
1969年 | 2篇 |
排序方式: 共有1930条查询结果,搜索用时 0 毫秒
61.
62.
Brenda Happell RN Cert Psych Nurs BA DipEd MEd PhD FACMHN Shifra Waks BA MIHP B Int Global Stud Aine Horgan PhD MSc BNS PGCert T&L RPN Sonya Greaney DipSPH PG Cert Peer Support Fionnuala Manning John Goodwin MA PGDip Bsc BA ALCM DipMgmt RPN Julia Bocking BPhil B Soc & Comm Stud Brett Scholz BHSci PhD Elisabeth Hals MA Arild Granerud PhD Rory Doody B.Soc.Sc. Chris Platania-Phung BA PhD Martha Griffin H. Dip in Community Youth Work Siobhan Russell BSc RPN PhD Liam MacGabhann BSc MSc DrNursSci Jarmo Pulli Annaliina Vatula BA Graeme Browne RN MHN PhD FACMHN Kornelis Jan van der Vaart BN MSci Jerry Allon Einar Bjornsson Heikki Ellilä RN MNSc PhD Mari Lahti MNSc PhD Pall Biering PhD 《Perspectives in psychiatric care》2020,56(4):811-819
63.
PG Kareru JM Keriko GM Kenji GT Thiong'o AN Gachanja HN Mukiira 《African journal of traditional, complementary, and alternative medicines》2010,7(3):214-218
In this study, Tithonia diversifolia Helms. (A Gray), Aloe secundiflora (Miller) and Azadirachta indica (A. Juss) plant extracts were used to make herbal soaps while Thevetia peruviana (Schum) seed oil was used to make a herbal lotion for skincare. The soaps were tested for the growth inhibition of Escherichia coli, and Candida albicans. The lotion was evaluated against Staphylococcus aureus and E.coli. Although Tithonia diversifolia soap exhibited the highest inhibitory effect on the test bacterial strains, it had the least inhibition against C. albicans. Results from this study indicated that the ‘Tithonia diversifolia’ soap would have superior skin protection against the tested bacteria but would offer the least skin protection against C. albicans. The herbal lotion inhibited S. aureus and E. coli in a concentration dependent manner, however, the inhibitory effect was more pronounced on S. aureus. 相似文献
64.
65.
Knowledge,attitude and practice among Health Visitors in the United Kingdom toward children's oral health 下载免费PDF全文
66.
Schalkwijk CG Lieuw-a-Fa M van Hinsbergh VW Stehouwer CD 《Seminars in vascular medicine》2002,2(2):191-197
Early and advanced nonenzymatic glycation of proteins are increased in diabetes. Although Amadori-glycated proteins are the major glycated modifications, most studies so far have focused on the role of advanced glycation end-products (AGEs) in diabetes-related vascular complications. It was only recently that the role of Amadori-glycated proteins has come under consideration. Here we review data that point to an important role of Amadori-modified glycated serum proteins in diabetic microangiopathy. Amadori-glycated albumin induces the activation of glomerular mesangial and endothelial cells to a phenotype that may be linked to the pathogenesis of diabetic microangiopathy, that is, by the stimulation of protein kinase C, activation of transforming growth factor beta, and the expression of extracellular matrix proteins. In type 1 diabetic patients, levels of Amadori-glycated proteins are independently associated with nephropathy and retinopathy. Reduction of Amadori-glycated albumin levels in diabetic animal models ameliorates the progression of nephropathy and retinopathy, indicating a causal role of Amadori-glycated proteins in the pathogenesis of diabetic nephropathy and retinopathy. Based on these data, inhibition of Amadori-glycated albumin may be a target for reduction of diabetic vascular complications. 相似文献
67.
Naoya Uchida Kareem N Washington Coen J Lap Matthew M Hsieh John F Tisdale 《Molecular therapy》2011,19(1):133-139
Position effects limit the curative potential of gene transfer strategies for the hemoglobinopathies by inducing clonal variability of transgene expression. We evaluated the mitigating effects of the chicken hypersensitivity site 4 (HS4) insulator among lentiviral vector-transduced human hematopoietic cells. We constructed various lentiviral vectors using a green fluorescent protein (GFP) reporter under the control of a reverse-oriented murine stem cell virus (MSCV)-long-term repeat (LTR) promoter or a reverse-oriented β-globin expression cassette. A full-length HS4, a tandem HS4 core, and a single core insulator were inserted into the 3′ LTR in both forward and reverse orientation. All but the reverse single core insulator significantly decreased titers. All reduced %GFP without increasing mean fluorescence intensity (MFI) among erythroid progeny of transduced human CD34+ cells. A lower coefficient of variation (CV) was observed only among progeny of the full-length vector-transduced cells, yet a fivefold reduction in transduction efficiency was observed. In xenografted mice, the single core insulator decreased both the %GFP and the MFI at 4 and 8 weeks after transplantation with no difference in CVs. These data demonstrate that the inclusion of HS4 insulator elements lowers viral titers, reduces efficiency of transduction, and produces minimal effects on transgene expression among human hematopoietic cells in vitro and in vivo. 相似文献
68.
van Greevenbroek MM Jacobs M van der Kallen CJ Blaak EE Jansen EH Schalkwijk CG Feskens EJ Stehouwer CD 《International journal of cardiology》2012,154(2):158-162
Background
Complement C3 is an emerging risk factor for coronary heart disease (CHD) and is particularly increased in the metabolic syndrome. A direct effect of smoking on structure and function of complement C3 has been suggested.Hypothesis
Smoking behavior may affect the cardiovascular risk that is associated with plasma complement C3.Methods
The association between plasma C3 and CHD was studied in the CODAM (Cohort on Diabetes and Atherosclerosis Maastricht) study population (n = 562, 61% male) with examination of effect modification by smoking.Results
The overall prevalence of CHD was 23.3%. Higher plasma C3 levels were associated with a higher CHD prevalence, and there was a significant interaction with heavy smoking (p = 0.01). In never & light smokers, the univariate OR for CHD per 1 s.d. (0.33 g/L) increase in C3 was 1.09 [95% confidence interval (CI) 0.85-1.41] (p = 0.505) whereas in heavy smokers it was 2.05 [1.43-2.93] (p < 0.001). The association in the group of heavy smokers remained significant (OR 2.38 [1.54-3.68], p < 0.001) after adjustment for traditional risk factors for cardiovascular disease and also after further adjustment for other cardiometabolic risk factors, i.e. the metabolic syndrome, CRP and insulin resistance (HOMA2IR) (OR C3 between 2.16 and 2.29, all p ≤ 0.001).Conclusion
Human plasma complement C3 is associated with prevalent CHD, but only in heavy smokers, and this association is independent of important metabolic cardiovascular risk factors. 相似文献69.
70.
Robert W. McConkey RANP RNP MSc BSc PG Dip PG Cert Therese Kelly RANP RNP MSc PG Dip PG Cert Rachael Dalton RANP RNT RNP MSc BSc PG Dip Geraldine Rooney cANP RNP BSc PG Dip PG Cert Michelle Healy cANP BSc PG Cert Louise Murphy PhD BSc PG Dip RPN RNT Maura Dowling PhD MSc RGN RNT 《International Journal of Urological Nursing》2023,17(1):78-83
Evidence based practice is essential to advanced practice nursing, enabling the delivery of quality care and improved patient outcomes. As the name suggests, it requires healthcare decisions to be based on the best available and current evidence. Advanced practice nurses need astute critical analysis skills to appraise the evolving literature, and require research skills to lead on scientific inquiry and develop the profession. Yet, advanced practice nurses may not recognize themselves as research leaders. Participation in a journal club can promote evidence-based practice, improve clinician's critical thinking skills, and expose members to different research methodologies, however, nurses continue to face barriers to participation in these clubs. Establishing a clinical-academic partnership appears to be both mutually beneficial for clinicians and academics and is a significant enabler in the sustainability and functioning of the club through sharing expertise and experience. A supportive workplace culture is favourable to research utilization and knowledge translation. This paper outlines the role, practicalities, challenges, and benefits of setting up a hybrid urology journal and research club for advanced practice nurses in a clinical-academic partnership. 相似文献