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García-Fernández Antía Gerardi Maria Chiara Crisafulli Francesca Filippini Matteo Fredi Micaela Gorla Roberto Lazzaroni Maria Grazia Lojacono Andrea Nalli Cecilia Ramazzotto Francesca Taglietti Marco Zanardini Cristina Zatti Sonia Franceschini Franco Tincani Angela Andreoli Laura 《Clinical rheumatology》2021,40(1):239-244
Clinical Rheumatology - To study disease activity during pregnancy and obstetric outcomes in patients with juvenile idiopathic arthritis (JIA) upon different subsets and with focus on medication... 相似文献
54.
Cristiane Canan Felipe Tsuruta Lisboa Cruz Fernanda Delaroza Rubia Casagrande Cleonice Pereira Mendes Sarmento Massami Shimokomaki Elza Iouko Ida 《Journal of food composition and analysis》2011,24(7):1057-1063
The objective of this work was to develop rice bran IRGA 417 phytic acid (PA) extraction and purification techniques. For the extraction of PA, a complete 24 factorial design with triplicates at the central point was used, and the effects of concentration of rice bran and HCl, time and temperature were investigated. During purification, different pH values were tested with addition of 1.5 M Na2CO3 or 4.0 M NaOH. The results obtained by the statistical analysis of the factorial design showed that temperature, time and HCl concentration influenced the PA extraction technique significantly (p ≤ 0.05), whereas the concentration of rice bran had no influence. The content of PA was evaluated in all the stages of purification and it was possible to establish an improved methodology of extraction and purification with high purity and yields. 相似文献
55.
Tatiana Barichello Geruza Z. Silva Jaqueline S. Generoso Geovana D. Savi Cleonice M. Michelon Gustavo Feier Clarissa M. Comim João Quevedo 《Journal of neural transmission (Vienna, Austria : 1996)》2010,117(7):819-826
Alterations in hippocampus frequently occur following bacterial meningitis, despite antibiotic treatment. We investigated
the cognitive performance in rats submitted to bacterial meningitis after 10, 30, and 60 days. To this aim, we utilized male
Wistar rats submitted to either sham (control) or meningitis by Streptococcus pneumoniae, and followed by the initiation of the antibiotic treatment at 16 h after inoculation. The animals underwent six behavioral
tasks 10, 30 and 60 days after surgery. We demonstrated that some of the learning and memory impairment, demonstrated 10 days
after the induction of meningitis, persists up to 30 days, but not 60 days after induction. 相似文献
56.
Silvia Lima Costa Victor Diogenes Amaral Silva Cleide dos Santos Souza Cleonice Creusa Santos Irmgard Paris Patricia Muñoz Juan Segura-Aguilar 《Neurotoxicity research》2016,30(1):41-52
Neurodegenerative disorders have a common characteristic that is the involvement of different cell types, typically the reactivity of astrocytes and microglia, characterizing gliosis, which in turn contributes to the neuronal dysfunction and or death. Flavonoids are secondary metabolites of plant origin widely investigated at present and represent one of the most important and diversified among natural products phenolic groups. Several biological activities are attributed to this class of polyphenols, such as antitumor activity, antioxidant, antiviral, and anti-inflammatory, among others, which give significant pharmacological importance. Our group have observed that flavonoids derived from Brazilian plants Dimorphandra mollis Bent., Croton betulaster Müll. Arg., e Poincianella pyramidalis Tul., botanical synonymous Caesalpinia pyramidalis Tul. also elicit a broad spectrum of responses in astrocytes and neurons in culture as activation of astrocytes and microglia, astrocyte associated protection of neuronal progenitor cells, neuronal differentiation and neuritogenesis. It was observed the flavonoids also induced neuronal differentiation of mouse embryonic stem cells and human pluripotent stem cells. Moreover, with the objective of seeking preclinical pharmacological evidence of these molecules, in order to assess its future use in the treatment of neurodegenerative disorders, we have evaluated the effects of flavonoids in preclinical in vitro models of neuroinflammation associated with Parkinson’s disease and glutamate toxicity associated with ischemia. In particular, our efforts have been directed to identify mechanisms involved in the changes in viability, morphology, and glial cell function induced by flavonoids in cultures of glial cells and neuronal cells alone or in interactions and clarify the relation with their neuroprotective and morphogetic effects. 相似文献
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Sandra Gofinet Pasoto Renato Romera Natalino Henrique Pires Chakkour Vilma dos Santos Trindade Viana Cleonice Bueno Elaine Pires Leon Margarete Borges Gualhardo Vendramini Mauricio Levy Neto Eloisa Bonfa 《Rheumatology international》2013,33(5):1149-1157
Antibody to Epstein–Barr virus (EBV) early antigen diffuse (anti-EA-D) is associated with viral replication. However, their possible associations with clinical/therapeutic features in primary Sjögren’s syndrome (pSS) were not established. We evaluated 100 pSS patients (American–European Criteria) and 89 age/gender/ethnicity-matched healthy controls. Disease activity was measured by EULAR Sjögren’s Syndrome Disease Activity Index (ESSDAI). Antibodies to EBV (anti-VCA IgG/IgM, anti-EBNA-1 IgG, anti-EA-D IgG) were determined by ELISA. Patients and controls had comparable frequencies and mean levels of anti-VCA IgG (90 vs. 86.5 %, p = 0.501; 2.6 ± 1.1 vs. 2.5 ± 1.1 AU/mL, p = 0.737) and anti-EBNA-1 IgG (92 vs. 94.4 %, p = 0.576; 141.3 ± 69.8 vs. 135.6 ± 67.5 RU/mL, p = 0.464). Anti-VCA IgM was negative in all cases. Noteworthy, higher frequency and increased mean levels of anti-EA-D were observed in patients than controls (36 vs. 4.5 %, p < 0.0001; 38.6 ± 57.4 vs. 7.9 ± 26.3 RU/mL, p < 0.0001). Further analysis of patients with (n = 36) and without (n = 64) anti-EA-D revealed comparable age/gender/ethnicity (p ≥ 0.551), current prednisone dose (4.8 ± 6.9 vs. 5.1 ± 10.4 mg/day, p = 0.319), and current uses of prednisone (52.8 vs. 37.5 %, p = 0.148) and immunosuppressants (44.4 vs. 31.3 %, p = 0.201). ESSDAI values were comparable (p = 0.102), but joint activity was more frequent (25 vs. 9.4 %, p = 0.045) in anti-EA-D positive patients. Anti-EA-D antibodies were not associated with anti-Ro/SSA (p = 1.000), anti-La/SSB (p = 0.652), rheumatoid factor (p = 1.000), anti-α-fodrin (p = 0.390) or antiphospholipid antibodies (p = 0.573), not suggesting cross-reactivity. The higher anti-EA-D frequency associated with joint activity raises the possibility that a subclinical EBV reactivation may trigger or perpetuate the articular involvement in pSS. 相似文献
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Hong Chen Genevieve Ko Alessandra Zatti Giuseppina Di Giacomo Lijuan Liu Elisabetta Raiteri Ezio Perucco Chiara Collesi Wang Min Caroline Zeiss Pietro De Camilli Ottavio Cremona 《Proceedings of the National Academy of Sciences of the United States of America》2009,106(33):13838-13843
Epsins are endocytic adaptors with putative functions in general aspects of clathrin-mediated endocytosis as well as in the internalization of specific membrane proteins. We have now tested the role of the ubiquitously expressed epsin genes, Epn1 and Epn2, by a genetic approach in mice. While either gene is dispensable for life, their combined inactivation results in embryonic lethality at E9.5–E10, i.e., at the beginning of organogenesis. Consistent with studies in Drosophila, where epsin endocytic function was linked to Notch activation, developmental defects observed in epsin 1/2 double knockout (DKO) embryos recapitulated those produced by a global impairment of Notch signaling. Accordingly, expression of Notch primary target genes was severely reduced in DKO embryos. However, housekeeping forms of clathrin-mediated endocytosis were not impaired in cells derived from these embryos. These findings support a role of epsin as a specialized endocytic adaptor, with a critical role in the activation of Notch signaling in mammals. 相似文献
60.
OBJECTIVE: To verify if Apgar score plus umbilical cord pH are adequate to predict which newborn infant will develop multiorgan system disfunction. METHODS: A study including all term newborn infants with Apgar scores in the first and fifth minutes of life < 7 and umbilical cord blood pH < 7.20 born in Hospital de Clínicas de Porto Alegre from March 1995 through March 1998 was performed. Venous umbilical cord blood was collected for blood gas analysis. Newborn infants were divided in two groups: Group A with pH < 7.0, and Group B with pH >/= 7.0 and < 7.20. Patients were evaluated for the presence of pulmonary hypertension, renal failure, inappropriate secretion of antidiuretic hormone, ischemic cardiopathy, early seizures, neurologic injury at hospital discharge and death. RESULTS: Twenty five newborn infants were included in the study.Twelve formed Group A, and 13, Group B. There were no differences between both groups in respect to mode of delivery, gender, color and birth weight. Group B had a lower gestational age than Group A. There were significant differences between both groups in mean cord blood pH, pCO(2) and BE (p<0.05). There was a positive association between umbilical cord blood pH and Apgar score. Higher occurrence of neurologic injury at hospital discharge in Group A was the only statistically significant clinical manifestation (p<0.05). CONCLUSION: Apgar score and umbilical cord pH are not adequate criteria to predict multiorgan system dysfunction. 相似文献