全文获取类型
收费全文 | 180429篇 |
免费 | 1241篇 |
国内免费 | 34篇 |
专业分类
耳鼻咽喉 | 1223篇 |
儿科学 | 6693篇 |
妇产科学 | 3105篇 |
基础医学 | 17257篇 |
口腔科学 | 1591篇 |
临床医学 | 12696篇 |
内科学 | 31659篇 |
皮肤病学 | 932篇 |
神经病学 | 16836篇 |
特种医学 | 9407篇 |
外科学 | 29567篇 |
综合类 | 2344篇 |
一般理论 | 1篇 |
预防医学 | 18270篇 |
眼科学 | 2891篇 |
药学 | 9714篇 |
中国医学 | 627篇 |
肿瘤学 | 16891篇 |
出版年
2023年 | 36篇 |
2022年 | 65篇 |
2021年 | 125篇 |
2020年 | 102篇 |
2019年 | 134篇 |
2018年 | 22040篇 |
2017年 | 17471篇 |
2016年 | 19605篇 |
2015年 | 1041篇 |
2014年 | 956篇 |
2013年 | 986篇 |
2012年 | 7289篇 |
2011年 | 21344篇 |
2010年 | 18996篇 |
2009年 | 11694篇 |
2008年 | 19810篇 |
2007年 | 22003篇 |
2006年 | 860篇 |
2005年 | 2468篇 |
2004年 | 3684篇 |
2003年 | 4639篇 |
2002年 | 2685篇 |
2001年 | 322篇 |
2000年 | 446篇 |
1999年 | 234篇 |
1998年 | 274篇 |
1997年 | 271篇 |
1996年 | 138篇 |
1995年 | 142篇 |
1994年 | 137篇 |
1993年 | 83篇 |
1992年 | 78篇 |
1991年 | 113篇 |
1990年 | 155篇 |
1989年 | 101篇 |
1988年 | 78篇 |
1987年 | 64篇 |
1986年 | 49篇 |
1985年 | 57篇 |
1984年 | 45篇 |
1983年 | 51篇 |
1982年 | 51篇 |
1980年 | 58篇 |
1978年 | 31篇 |
1969年 | 31篇 |
1938年 | 61篇 |
1937年 | 31篇 |
1934年 | 31篇 |
1932年 | 57篇 |
1930年 | 50篇 |
排序方式: 共有10000条查询结果,搜索用时 0 毫秒
41.
42.
Sergio Barroilhet Adrián Cano-Prous Salvador Cervera-Enguix Maria João Forjaz Francisco Guillén-Grima 《Social psychiatry and psychiatric epidemiology》2009,44(12):1051-1065
Introduction
This paper presents the results of a study on the psychometric properties of an authorized Spanish version of the McMaster Family Assessment Device, a self-report measure of family functioning. 相似文献43.
Andreas Lange Claudia Kistler Tanja B. Jutzi Alexandr V. Bazhin Claus Detlev Klemke Dirk Schadendorf Stefan B. Eichmüller 《Experimental dermatology》2009,18(6):527-535
Abstract: The identification of tumor-specific proteins located at the plasma membrane is hampered by numerous methodological pitfalls many of which are associated with the post-translational modification of such proteins. Here, we present a new combination of detergent fractionation of cells and of subtractive suppression hybridization (SSH) to gain overexpressed genes coding for membrane-associated or secreted proteins. Fractionation of subcellular components by digitonin allowed sequestering mRNA of the rough Endoplasmatic reticulum and thereby increasing the percentage of sequences coding for membrane-bound proteins. Fractionated mRNAs from the cutaneous T-cell lymphoma (CTCL) cell line HuT78 and from normal peripheral blood monocytes were used for SSH leading to the enrichment of sequences overexpressed in the tumor cells. We identified some 21 overexpressed genes, among them are GPR137B, FAM62A, NOMO1, HSP90, SLIT1, IBP2, CLIF, IRAK and ARC. mRNA expression was tested for selected genes in CTCL cell lines, skin specimens and peripheral blood samples from CTCL patients and healthy donors. Several of the detected sequences are clearly related to cancer, but have not yet been associated with CTCL. qPCR confirmed an enrichment of these mRNAs in the rough endoplasmic reticulum fraction. RT-PCR confirmed the expression of these genes in skin specimens and peripheral blood of CTCL patients. Western blotting verified protein expression of HSP90 and IBP2 in HuT78. GPR137B could be detected by immunohistology in HuT78 and in keratinocytes of dysplastic epidermis, but also in sweat glands of healthy skin. In summary, we developed a new technique, which allows identifying overexpressed genes coding preferentially for membrane-associated proteins. 相似文献
44.
45.
46.
47.
Introduction
Although ependymoma is the third most common pediatric brain tumor, we know little about the genetic/epigenetic basis of its initiation, maintenance, or progression. This is due in part to the heterogeneity of the disease, as well as the small sample size of the cohorts analyzed in most studies. 相似文献48.
Peter Angelos 《World journal of surgery》2009,33(4):609-611
49.
Kentaroh Miyoshi Minoru Naito Tsuyoshi Ueno Shinji Hato Hideo Ino 《General thoracic and cardiovascular surgery》2009,57(11):629-632
A benign esophageal leiomyoma with abnormally increased fluorine-18-fluorodeoxyglucose uptake on positron emission tomography
(PET) was resected thoracoscopically. The tumor, of which the maximum standardized uptake value of the lesion was 4.7, was
well defined and 38 mm in diameter. Neither mitotic activity nor degeneration was found histologically; and immunoreactivity
for CD34, CD117, MIB-1, and glucose transporter-1 was negative immunohistochemically. A diagnosis of gastrointestinal stromal
tumor was ruled out by an oncogenic kinase gene mutation study. This case cautions against PET-dependent evaluation for malignant
potential of esophageal submucosal tumors. 相似文献
50.