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671.
缺氧对海马神经元培养的影响及巴曲酶的保护作用—HSP70的表达及细胞形态学的研究 总被引:2,自引:0,他引:2
本文采用新生大鼠海马神经元培养技术,以细胞形态学及HSP70免疫阳性细胞表达为指标,首次观察了巴曲酶对缺氧海马神经元损伤的直接保护作用。结果发现:在缺氧前0.5h给予巴曲酶(0.5BU/ml),海马神经细胞存活率以及HSP70免疫阳性细胞率均明显高于缺氧对照组(P<0.01),而在缺氧前24h给予巴曲酶后,二者与缺氧对照组均无明显差别。表明:巴曲酶对缺氧海马神经细胞损伤有直接的保护作用,而且其作用与给药的时机有关。 相似文献
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Danias PG; McConnell MV; Khasgiwala VC; Chuang ML; Edelman RR; Manning WJ 《Radiology》1997,203(3):733
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Malaine Morais Alves Machado Mirella de Paiva Lopes Raquel Machado Schincaglia Paulo Srgio Sucasas da Costa Alexandre Siqueira Guedes Coelho Maria Claret Costa Monteiro Hadler 《Nutrients》2021,13(7)
Fortification with multiple micronutrient powder has been proposed as a public health intervention able to reduce micronutrient deficiencies in children. Our objective was to compare the effectiveness of fortification with multiple micronutrient powder with drug supplementation in the prevention and treatment of iron deficiency and anaemia. This was a cluster trial with anemic and non-anaemic children between six and 42 months old, in randomization data. Non anaemic children received fortification with multiple micronutrient powder or standard drug supplementation of ferrous sulfate associated with folic acid in a prevention dose. Anaemic children who were randomized to receive multiple micronutrient powder also received the recommended iron complementation for anaemia treatment. A total of 162 children were evaluated. The prevalence of anaemia decreased from 13.58 to 1.85%. Iron deficiency decreased from 21.74% to 7.89% (by serum ferritin) and iron deficiency decreased from 66.81 to 38.27% (by soluble transferrin receptor). No difference was identified between interventions for hemoglobin (p = 0.142), serum ferritin (p = 0.288), and soluble transferrin receptor (p = 0.156). Fortification with multiple micronutrient powder was effective in preventing iron deficiency and anaemia in children aged six to 48 months. In anaemic children; it was necessary to supplement the dose of multiple micronutrient powder with ferrous sulfate. 相似文献
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Middle East respiratory syndrome coronavirus neutralising serum antibodies in dromedary camels: a comparative serological study 总被引:1,自引:0,他引:1
Chantal BEM Reusken Bart L Haagmans Marcel A Müller Prof Carlos Gutierrez Gert-Jan Godeke Benjamin Meyer Doreen Muth V Stalin Raj Laura Smits-De Vries Victor M Corman Jan-Felix Drexler Saskia L Smits Yasmin E El Tahir Rita De Sousa Janko van Beek Prof Norbert Nowotny Kees van Maanen Ezequiel Hidalgo-Hermoso Berend-Jan Bosch Prof Peter Rottier Prof Albert Osterhaus Christian Gortázar-Schmidt Prof Christian Drosten Prof Marion PG Koopmans 《The Lancet infectious diseases》2013,13(10):859-866
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Jeffs LS Peh CA Nelson A Tan PG Davey E Chappell K Perkins GB Hurtado PR 《Immunologic research》2019,67(4-5):325-336
Immunologic Research - Low levels of IgM auto-antibodies have been reported in health and disease. IgM anti-neutrophil cytoplasmic antibodies (ANCA) have been reported in patients with... 相似文献
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Characteristic chromosomal aberrations have been associated with subtypes of non-Hodgkin's lymphoma with distinct clinicopathologic features. Low-grade B-cell lymphomas of mucosa-associated lymphoid tissue (MALT) form such a group and might be expected to be characterized by a specific cytogenetic abnormality. Metaphase analyses of MALT lymphoma are rare due to problems with fresh tissue collection and poor in vitro proliferation. However, the small number of published series suggests that chromosome trisomies, particularly trisomy 3, might be characteristic of these tumors. The application of interphase cytogenetic techniques to routinely processed material allows the examination of a large series of archival cases and is particularly useful for the demonstration of chromosome trisomies. We have used this technique to analyze 70 cases of low-grade MALT lymphoma from various sites and found trisomy 3 in 60%. This finding compares with 16% in low- grade nodal B-cell lymphoma and 27% in primary splenic lymphoma of marginal zone type (splenic lymphoma with villous lymphocytes). These results provide further evidence that low-grade MALT lymphomas from all sites form a single pathologic entity distinct from nodal B-cell lymphomas. Although MALT lymphoma and primary splenic lymphoma may arise from marginal zone B cells, they are genetically distinct. 相似文献