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Alexandra Carl;Marybel Good;Erica Haag;Christa Hutaff-Lee;Deanna Swain;Nicole Tartaglia;Casey Sakamoto;Shanlee Davis;Talia Thompson; 《American journal of medical genetics. Part A》2024,194(8):e63564
Turner syndrome (TS), caused by complete or partial loss of the second sex chromosome, is associated with complex medical manifestations. The TS community identifies anxiety as a major contributor to reduced quality of life. The study aimed to improve understanding of anxiety symptomatology, diagnosis, and care in individuals with TS. A mixed methods design integrated community engagement, including community leaders as co-investigators and a community advisory board, an online survey (N = 135), and in-depth interviews (N = 10). The majority of respondents reported that anxiety symptoms occur two or more days per week, with self-advocates reporting more frequent symptoms than caregivers (p = 0.03). Self-advocates reported feeling anxious more often at school/work; both rater groups reported anxiety-related behaviors were most likely to be expressed at home. Insomnia was the most common symptom of anxiety endorsed across age and rater groups (>70%). Anxiety symptoms and triggers changed with age and often were undiagnosed or untreated during childhood. Therapy and medication were reported as helpful by most respondents who had tried these strategies. Qualitative themes included: ‘Triggers for anxiety are related to TS’, ‘Anxiety impacts the whole family’, and ‘Opportunities for early identification and intervention’. 相似文献
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Georg Peschel Kilian Weigand Jonathan Grimm Martina M&# ller Christa Buechler 《World journal of hepatology》2023,15(12):1315-1324
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Nikou L. Damestani;John Jacoby;Christa B. Michel;Barnaly Rashid;David H. Salat;Meher R. Juttukonda; 《Journal of magnetic resonance imaging : JMRI》2024,60(4):1549-1562
Changes in cerebral hemodynamics with aging are important for understanding age-related variation in neuronal health. While many prior studies have focused on gray matter, less is known regarding white matter due in part to measurement challenges related to the lower vascular density in white matter. 相似文献
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Summary The application of -bungarotoxin onto the chorio-allantoic membrane of chick embryos between the 11th and 18th day of incubation leads to alterations of retinal development. The most significant qualitative change is the appearance of retinal rosettes formed by receptor cells. These rosettes are infoldings of the receptor cell layer. Quantitatively, an enlargement in volume of the receptor and outer nuclear layer can be found together with a simultaneous decrease of the other retinal layers. The toxin seems to suspend the naturally occurring nerve cell death in the receptor cell population.In honour of the 90th birthday of Prof. Dr.Dr. h.c. hermann Voss 相似文献
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